Mitochondria-targeted antioxidant SS31 prevents Amyloid beta-induced mitochondrial abnormalities and synaptic degeneration in Alzheimer's disease

Pharmaceuticals

Volumn 5, Issue 10, 2012, Pages 1103-1119

  Calkins, Marcus J ^a,b   Manczak, Maria ^a   Hemachandra Reddy, P ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Alzheimer's; Antioxidant; Mitochondria; SS31

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMPA RECEPTOR; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; CALCIUM ION; CURCUMIN; CYTOCHROME C OXIDASE; DIMEBON; EPIGALLOCATECHIN GALLATE; GINKGO BILOBA EXTRACT; IDEBENONE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOCHONDRIAL TRANSCRIPTION FACTOR B; MITOCHONDRIAL TRANSCRIPTION FACTOR TFB1M; MITOCHONDRIAL TRANSCRIPTION FACTOR TFB2M; NEUROPROTECTIVE AGENT; PEPTIDE SS31; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PRAMIPEXOLE; RESVERATROL; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; UBIQUINONE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BRAIN MITOCHONDRION; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL FUNCTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA REPLICATION; DRUG EFFICACY; ENZYME ACTIVITY; HUMAN; MITOCHONDRIAL BALANCE; MITOCHONDRION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC MEMBRANE; REVIEW; SYNAPTIC POTENTIAL;

EID: 84869231972     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5101103     Document Type: Review

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