Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans

Annals of Nutrition and Metabolism

Volumn 62, Issue 1, 2013, Pages 1-6

  Gato, Nobuki ^a   Kadowaki, Akio ^a   Hashimoto, Natsumi ^a   Yokoyama, Shin Ichiro ^b   Matsumoto, Kenji ^c  

^a Nakano BC Co Ltd   (Japan)

^b Gifu Prefectural Government   (Japan)

^c ISHIKAWA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Bile acid binding ability; Hypocholesterolemic effect; Intervention study; Tannin rich fiber; Young persimmon fruits

Indexed keywords

BILE ACID; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TANNIN RICH FIBER; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PERSIMMON EXTRACT; PLANT EXTRACT; TANNIN;

ADULT; ARTICLE; CHEMICAL COMPOSITION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG BINDING; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; LOW DRUG DOSE; MALE; PERSIMMON; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; CLINICAL ARTICLE; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BILE ACIDS AND SALTS; BLOOD GLUCOSE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY FIBER; DIOSPYROS; DOUBLE-BLIND METHOD; FEMALE; FRUIT; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; PLANT EXTRACTS; TANNINS; TRIGLYCERIDES;

DIOSPYROS; DIOSPYROS KAKI;

EID: 84869218134     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000343787     Document Type: Article

References (23)

1. Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC: Hypercholesterolemia and microvascular dysfunction: interventional strategies. J Inflamm (Lond) 2010; 7:54.
2. Kramer W, Glombik H: Bile acid reabsorp-tion inhibitors (BARI): novel hypolipidemic drugs. Curr Med Chem 2006; 13: 997-1016.
3. Staels B, Handelsman Y, Fonseca V: Bile acid sequestrants for lipid and glucose control. Curr Diab Rep 2010; 10:70-77.
4. Kobayashi M, Ikegami H, Fujisawa T, Nojima K, Kawabata Y, Noso S, Babaya N, Itoi-Babaya M, Yamaji K, Hiromine Y, Shibata M, Ogihara T: Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes 2007; 56: 239-247.
5. Fonseca VA, Rosenstock J, Wang AC, Truitt KE, Jones MR: Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy. Diabetes Care 2008; 31: 1479-1484.
6. Gorinstein S, Bartnikowska E, Kulasek G, Zemser M, Trakhtenberg S: Dietary persimmon improves lipid metabolism in rats fed diets containing cholesterol. J Nutr 1998; 128:2023-2027.
7. Matsumoto K, Watanabe Y, Ohya M, Yo-koyama S: Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity model. Biol Pharm Bull 2006; 29:2532-2535.
8. Matsumoto K, Yokoyama S, Gato N: Hypo-lipidemic effect of young persimmon fruit in C57BL/6.KOR-ApoEshl mice. Biosci Bio-technol Biochem 2008; 72: 2651-2659.
9. Matsumoto K, Yokoyama S, Gato N: Bile acid-binding activity of young persimmon (Diospyros kaki) fruit and its hypolipidemic effect in mice. Phytother Res 2010; 24:205-210.
10. Matsumoto K, Yokoyama S: Geneex pression analysis on the liver of cholestyramine-treat-ed type 2 diabetic mice. Biomed Pharmaco-ther 2010; 64: 373-378.
11. Matsumoto K, Kadowaki A, Ozaki N, Take-naka M, Ono H, Yokoyama S, Gato N: Bile acid-binding ability of kaki-tannin from young fruits of persimmon (Diospyros kaki) in vitro and in vivo. Phytother Res 2011; 25: 624-628.
12. Matsumoto K, Yokoyama S: Induction of uncoupling protein-1 and-3 in brown adipose tissue by kak i-tannin in ty pe 2 diabetic NSY/Hos mice. Food Chem Tox icol 2012; 50: 184-190.
13. Takekawa K, Matsumoto K: Water-insoluble condensed tannins content of young persimmon fruits-derived crude fibre relates to its bile acid-binding ability. Nat Prod Res 2012;26:2255-2258.
14. McConnell EL, Fadda HM, Basit AW: Gut instincts: explorations in intestinal physiology and drug delivery. Int J Pharm 2008; 364: 213-226.
15. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1977; 18: 499-502.
16. Matsuo T, Ito S: The chemical structure of kaki-tannin from immature fruit of the persimmon (Diospyros kaki L.). Agric Biol Chem 1978; 42:1637-1643.
17. Chang SC, Lee MS, Lin CJ, Chen ML: Dietary fiber content and composition of fruits in Taiwan. Asia Pacific J Clin Nutr 1998; 7:206-210.
18. Brune M, Rossander L, Hallberg L: Iron absorption and phenolic compounds: importance of different phenolic structures. Eur J Clin Nutr 1989; 43:547-557.
19. Haque AM, Hashimoto M, Katakura M, Ta-nabe Y, Hara Y, Shido O: Long-term administration of green tea catechins improves spatial cognition learning ability in rats. J Nutr 2006; 136: 1043-1047.
20. Kim A, Chiu A, Barone MK, Avino D, Wang F, Coleman CI, Phung OJ: Green tea cate-chins decrease total and low-density lipopro-tein cholesterol: a systematic review and me-ta-analysis. J Am Diet Assoc 2011; 111:1720-1729.
21. Ganda OP: The role of bile acid sequestrants in the management of type 2 diabetes melli-tus. Metab Syndr Relat Disord 2010; 8(suppl 1): S15-S21.
22. Shang Q, Saumoy M, Holst JJ, Salen G, Xu G: Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. Am J Physiol Gastrointest Liver Physiol 2010; 298:G419-G424.
23. Holst JJ, McGill MA: Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mel-litus: focus on bile acid sequestrants. Clin Drug Investig 2012; 32:1-14.