Impact of metformin use on the prognostic value of lactate in sepsis

American Journal of Emergency Medicine

Volumn 30, Issue 9, 2012, Pages 1667-1673

  Green, Jeffrey P ^a   Berger, Tony ^a   Garg, Nidhi ^b   Suarez, Alison ^b   Hagar, Yolanda ^c   Radeos, Michael S ^b   Panacek, Edward A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK HOSPITAL QUEENS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; METFORMIN;

AGED; ARTICLE; DIABETES MELLITUS; DIABETIC PATIENT; DRUG USE; EMERGENCY WARD; FEMALE; HUMAN; HYPERLACTATEMIA; INFECTION; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TEACHING HOSPITAL;

AGED; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LACTATES; LOGISTIC MODELS; MALE; METFORMIN; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; SEPSIS;

EID: 84869198479     PISSN: 07356757     EISSN: 15328171     Source Type: Journal    
DOI: 10.1016/j.ajem.2012.01.014     Document Type: Article

References (32)

1. H.E. Wang, N.I. Shapiro, and D.C. Angus National estimates of severe sepsis in United States emergency departments Crit Care Med 35 8 2007 1928 1936
2. D.C. Angus, W.T. Linde-Zwirble, and J. Lidicker Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 7 2001 1303 1310
3. M.E. Mikkelsen, A.N. Miltiades, and D.F. Gaieski Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock Crit Care Med 37 5 2009 1670 1677
4. M.D. Howell, M. Donnino, and P. Clardy Occult hypoperfusion and mortality in patients with suspected infection Intensive Care Med 33 11 2007 1892 1899
5. S. Trzeciak, R.P. Dellinger, and M.E. Chansky Serum lactate as a predictor of mortality in patients with infection Intensive Care Med 33 6 2007 970 977
6. E. Rivers, B. Nguyen, and S. Havstad Early goal-directed therapy in the treatment of severe sepsis and septic shock N Engl J Med 345 19 2001 1368 1377
7. N.I. Shapiro, M.D. Howell, and D. Talmor Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol Crit Care Med 34 4 2006 1025 1032
8. H.B. Nguyen, S.W. Corbett, and R. Steele Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality Crit Care Med 35 4 2007 1105 1112
9. D. Juneja, O. Singh, and R. Dang Admission hyperlactatemia: causes, incidence, and impact on outcome of patients admitted in a general medical intensive care unit J Crit Care 26 3 2011 316 320
10. B. Levy Lactate and shock state: the metabolic view Curr Opin Crit Care 12 4 2006 315 321
11. S. Correia, C. Carvalho, and M.S. Santos Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview Mini Rev Med Chem 8 13 2008 1343 1354
12. J.D. Lalau Lactic acidosis induced by metformin: incidence, management and prevention Drug Saf 33 9 2010 727 740
13. S.R. Salpeter, E. Greyber, and G.A. Pasternak Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus Cochrane Database Syst Rev 1 2010 CD002967
14. Bristol-Meyers Squibb Company Glucophage (metformin hydrochloride) [package insert] 2009 Bristol-Myers Squibb Princeton (NJ) Distributed by
15. T. Scale, and J.N. Harvey Diabetes, metformin and lactic acidosis Clin Endocrinol (Oxf) 74 2 2011 191 196
16. J.P. Green, T. Berger, and N. Garg Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection Ann Emerg Med 57 3 2011 291 295
17. R.P. Dellinger, M.M. Levy, and J.M. Carlet Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 Crit Care Med 36 1 2008 296 327
18. E.A. Panacek Performing chart review studies Air Med J 26 5 2007 206 210
19. E.J. Gallagher, K. Rodriguez, and M. Touger Agreement between peripheral venous and arterial lactate levels Ann Emerg Med 29 4 1997 479 483
20. J. Quinn, N. Kramer, and D. McDermott Validation of the Social Security Death Index (SSDI): an important readily-available outcomes database for researchers West J Emerg Med 9 1 2008 6 8
21. A.D. Nichol, M. Egi, and V. Pettila Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study Crit Care 14 1 2010 R25
22. M.D. Howell, D. Talmor, and P. Schuetz Proof of principle: the predisposition, infection, response, organ failure sepsis staging system Crit Care Med 39 2 2011 322 327
23. A.T. Calabrese, K.C. Coley, and S.V. DaPos Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy Arch Intern Med. 162 4 2002 434 437
24. A. Holstein, and M. Stumvoll Contraindications can damage your health - is metformin a case in point? Diabetologia 48 12 2005 2454 2459
25. B. Schmitt-Honl Metformin. Contraindications in heart failure reconsidered Med Monatsschr Pharm 31 4 2008 148 149
26. H. Aikaike A new look at statistical model identification IEEE Trans Inf Theory 19 6 1974 716 723
27. D. Detaille, B. Guigas, and C. Chauvin Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process Diabetes 54 7 2005 2179 2187
28. P. Faure, N. Wiernsperger, and C. Polge Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin Clin Sci (Lond) 114 3 2008 251 256
29. Y. Kato, N. Koide, and T. Komatsu Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway Horm Metab Res 42 9 2010 632 636
30. A.M. Carter, C.E. Bennett, and J.A. Bostock Metformin reduces C-reactive protein but not complement factor C3 in overweight patients with type 2 diabetes mellitus Diabet Med 22 9 2005 1282 1284
31. B.B. Graham, A. Keniston, and O. Gajic Diabetes mellitus does not adversely affect outcomes from a critical illness Crit Care Med 38 1 2010 16 24
32. M. Egi, R. Bellomo, and E. Stachowski Blood glucose concentration and outcome of critical illness: the impact of diabetes Crit Care Med 36 8 2008 2249 2255