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Volumn 18, Issue 6, 2012, Pages 1315-1337

Statistical Comparison of Carcinogenic Effects and Dose-Response Relationships in Rats and Mice for 2,4-Toluene Diamine to those Ascribed to Toluene Diisocyanate

Author keywords

atypical (gavage) exposure conditions; flawed test substance handling and storage conditions; hydrolyze TDI to TDA; toluene diamine (TDA); toluene diisocyanate (TDI); tumorigenic responses in rats and mice

Indexed keywords


EID: 84869197869     PISSN: 10807039     EISSN: 15497860     Source Type: Journal    
DOI: 10.1080/10807039.2012.722853     Document Type: Article
Times cited : (7)

References (31)
  • 1
    • 34548496688 scopus 로고    scopus 로고
    • Biological monitoring of TDI-derived amines in polyurethane foam production
    • Austin, S. 2007. Biological monitoring of TDI-derived amines in polyurethane foam production. Occup Med, 57(6): 444-8.
    • (2007) Occup Med , vol.57 , Issue.6 , pp. 444-448
    • Austin, S.1
  • 2
    • 0025797675 scopus 로고
    • Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate
    • Brorson, T, Skarping, G and Sangö, C. 1991. Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate. Internat Arch Occup Environ Health, 63(4): 253-9.
    • (1991) Internat Arch Occup Environ Health , vol.63 , Issue.4 , pp. 253-259
    • Brorson, T.1    Skarping, G.2    Sangö, C.3
  • 3
    • 0030201065 scopus 로고    scopus 로고
    • Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: Implications for their carcinogenicity
    • Cheung, Y-L, Snelling, JMohammed, N ND. 1996. Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: Implications for their carcinogenicity. Toxicol Appl Pharmacol, 139: 203-11.
    • (1996) Toxicol Appl Pharmacol , vol.139 , pp. 203-211
    • Cheung, Y.-L.1    Snelling, J.2    Mohammed, N.N.D.3
  • 4
    • 0026073504 scopus 로고
    • Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen:carcinogen pair- 2,6- and 2,4-diaminotoluene
    • Cunningham, M L, Foley, JMaronpot, R R. 1991. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen:carcinogen pair- 2,6- and 2,4-diaminotoluene. Toxicol Appl Pharmacol, 107: 562-7.
    • (1991) Toxicol Appl Pharmacol , vol.107 , pp. 562-567
    • Cunningham, M.L.1    Foley, J.2    Maronpot, R.R.3
  • 5
    • 0025614776 scopus 로고
    • The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 2,4- and 2,6-TDI isomers
    • Dieter, M P, Boorman, G AJameson, C W. 1990. The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 2,4- and 2,6-TDI isomers. Toxicol Ind Health, 6(6): 599-621.
    • (1990) Toxicol Ind Health , vol.6 , Issue.6 , pp. 599-621
    • Dieter, M.P.1    Boorman, G.A.2    Jameson, C.W.3
  • 6
    • 0027218166 scopus 로고
    • Cancer incidence and mortality in the Swedish polyurethane foam manufacturing industry
    • Hagmar, L, Welinder, H and Mikoczy, Z. 1993a. Cancer incidence and mortality in the Swedish polyurethane foam manufacturing industry. Brit J Ind Med, 50: 537-43.
    • (1993) Brit J Ind Med , vol.50 , pp. 537-543
    • Hagmar, L.1    Welinder, H.2    Mikoczy, Z.3
  • 7
    • 0027495092 scopus 로고
    • Incidence of cancer and exposure to toluene diisocyanate and methylene diphenyldiisocyanate: A cohort based case referent study in the polyurethane foam manufacturing industry
    • Hagmar, L, Stromberg, UWelinder, H. 1993b. Incidence of cancer and exposure to toluene diisocyanate and methylene diphenyldiisocyanate: A cohort based case referent study in the polyurethane foam manufacturing industry. Brit J Ind Med, 50: 1003-7.
    • (1993) Brit J Ind Med , vol.50 , pp. 1003-1007
    • Hagmar, L.1    Stromberg, U.2    Welinder, H.3
  • 8
    • 8844232037 scopus 로고
    • Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
    • IARC (International Agency for Research on Cancer), Lyon, France, Lyon
    • IARC (International Agency for Research on Cancer). 1986. "Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans". In Some Chemicals Used in Plastics and Elastomers Vol. 39, 287-323. Lyon, France
    • (1986) Some Chemicals Used in Plastics and Elastomers , vol.39 , pp. 287-323
  • 10
    • 0034925463 scopus 로고    scopus 로고
    • Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: Determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA)
    • Kaaria, K, Hirvonen, ANorppa, H. 2001. Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: Determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA). Analyst, 126: 1025-31.
    • (2001) Analyst , vol.126 , pp. 1025-1031
    • Kaaria, K.1    Hirvonen, A.2    Norppa, H.3
  • 12
    • 0020664530 scopus 로고
    • Long-term toxicity and carcinogenicity studies with 2,4/2,6-TDI (80/20) in rats and mice
    • Löser, E. 1983. Long-term toxicity and carcinogenicity studies with 2,4/2,6-TDI (80/20) in rats and mice. Toxicol Letters, 15: 71-81.
    • (1983) Toxicol Letters , vol.15 , pp. 71-81
    • Löser, E.1
  • 13
    • 2442592846 scopus 로고    scopus 로고
    • Cancer incidence and mortality of isocyanate exposed workers from the Swedish polyurethane foam industry: Updated findings 1959-98
    • Mikoczy, Z, Welinder, HTinnerberg, H. 2004. Cancer incidence and mortality of isocyanate exposed workers from the Swedish polyurethane foam industry: Updated findings 1959-98. Occup Environ Med, 61: 432-37.
    • (2004) Occup Environ Med , vol.61 , pp. 432-437
    • Mikoczy, Z.1    Welinder, H.2    Tinnerberg, H.3
  • 14
    • 0004078420 scopus 로고
    • NTP (National Toxicology Program), Bethesda, MD, USA, Bethesda, MD,: National Institutes of Health, Technical report No. 162. NIH Publication No
    • NTP (National Toxicology Program). 1979. Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CAS No. 95-80-7), 79-1718. Bethesda, MD, USA: National Institutes of Health. Technical report No. 162. NIH Publication No
    • (1979) Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CAS No. 95-80-7) , pp. 79-1718
  • 16
    • 85172047583 scopus 로고
    • NTP, Bethesda, MD, USA, Bethesda, MD,: National Institutes of Health, 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Technical report No. 251. NIH Publication No
    • NTP. 1986. Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80%)-and 2,6 (20%)-Toluene Diisocyanate (CAS No, 86-2507. Bethesda, MD, USA: National Institutes of Health. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Technical report No. 251. NIH Publication No
    • (1986) Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80%)-and 2,6 (20%)-Toluene Diisocyanate (CAS No , pp. 86-2507
  • 17
    • 33750012321 scopus 로고    scopus 로고
    • NTP, Washington, DC, USA, Washington, DC,: US Department of Health and Human Services, Public Health Service
    • NTP. 2005. Report on Carcinogens, 11th edit, Washington, DC, USA: US Department of Health and Human Services, Public Health Service.
    • (2005) Report on Carcinogens, 11th edit
  • 19
    • 0027769537 scopus 로고
    • Biological monitoring of occupational exposure to toluene diisocyanate: Measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry
    • Persson, P, Dalene, MSkarping, G. 1993. Biological monitoring of occupational exposure to toluene diisocyanate: Measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry. Br J Ind Med, 50(12): 1111-8.
    • (1993) Br J Ind Med , vol.50 , Issue.12 , pp. 1111-1118
    • Persson, P.1    Dalene, M.2    Skarping, G.3
  • 20
    • 0021800759 scopus 로고
    • Detection of urinary amine metabolites in toluene diisocyanate exposed rats
    • Rosenberg, C and Savolainen, H. 1985. Detection of urinary amine metabolites in toluene diisocyanate exposed rats. J Chromatogr, 323(2): 429-33.
    • (1985) J Chromatogr , vol.323 , Issue.2 , pp. 429-433
    • Rosenberg, C.1    Savolainen, H.2
  • 21
    • 0029828397 scopus 로고    scopus 로고
    • Mortality of workers exposed to toluenedisocanate in the polyurethane foam industry
    • Schnorr, T, Steenland, KEgeland, G. 1996. Mortality of workers exposed to toluenedisocanate in the polyurethane foam industry. Occup Environ Med, 53: 703-7.
    • (1996) Occup Environ Med , vol.53 , pp. 703-707
    • Schnorr, T.1    Steenland, K.2    Egeland, G.3
  • 22
    • 0032903318 scopus 로고    scopus 로고
    • Chemical behavior of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test
    • Seel, K, Walber, UHerbold, B. 1999. Chemical behavior of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test. Mut Res, 438: 109-23.
    • (1999) Mut Res , vol.438 , pp. 109-123
    • Seel, K.1    Walber, U.2    Herbold, B.3
  • 23
    • 0141504136 scopus 로고    scopus 로고
    • Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate
    • Sennbro, C J, Lindh, C HTinnerberg, H. 2003. Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate. Biomarkers, 8(3-4): 204-17.
    • (2003) Biomarkers , vol.8 , Issue.3-4 , pp. 204-217
    • Sennbro, C.J.1    Lindh, C.H.2    Tinnerberg, H.3
  • 24
    • 0011906770 scopus 로고
    • Sensory Irritation Study of Mondur TD-80 in Sprague-Dawley Rats
    • Pittsburgh, PA, USA, Pittsburgh, PA,: now Bayer MaterialScience LLC, Study No. 86-341-02. Report No. 842. Mobay Corp
    • Shiotsuka, RN. 1987. "Sensory Irritation Study of Mondur TD-80 in Sprague-Dawley Rats". In Mobay Corporation, Corporate Toxicology Department, Pittsburgh, PA, USA: now Bayer MaterialScience LLC. Study No. 86-341-02. Report No. 842. Mobay Corp.
    • (1987) Mobay Corporation, Corporate Toxicology Department
    • Shiotsuka, R.N.1
  • 25
    • 0028226425 scopus 로고
    • Determination of toluenediamine isomers by capillary gas chromatography and chemical ionization mass spectrometry with special reference to the biological monitoring of 2,4- and 2,6-toluene diisocyanate
    • Skarping, G, Dalene, M and Lind, P. 1994. Determination of toluenediamine isomers by capillary gas chromatography and chemical ionization mass spectrometry with special reference to the biological monitoring of 2,4- and 2,6-toluene diisocyanate. J Chromotography, 663: 199-210.
    • (1994) J Chromotography , vol.663 , pp. 199-210
    • Skarping, G.1    Dalene, M.2    Lind, P.3
  • 26
    • 0036844796 scopus 로고    scopus 로고
    • Mortality and cancer morbidity of production workers in the UK flexible polyurethane foam industry: Updated findings 1958-98
    • Sorahan, T and Nichols, L. 2002. Mortality and cancer morbidity of production workers in the UK flexible polyurethane foam industry: Updated findings 1958-98. Occup Environ Med, 59: 751-8.
    • (2002) Occup Environ Med , vol.59 , pp. 751-758
    • Sorahan, T.1    Nichols, L.2
  • 27
    • 0027218165 scopus 로고
    • Mortality and cancer morbidity of production workers in the United Kingdom flexible polyurethane foam industry
    • Sorahan, T and Pope, D. 1993. Mortality and cancer morbidity of production workers in the United Kingdom flexible polyurethane foam industry. Brit J Ind Med, 50: 528-36.
    • (1993) Brit J Ind Med , vol.50 , pp. 528-536
    • Sorahan, T.1    Pope, D.2
  • 28
    • 0028296071 scopus 로고
    • Route-dependent comparative metabolism off [14C]toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats
    • Timchalk, C, Smith, F A and Bartels, M J. 1994. Route-dependent comparative metabolism off [14C]toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats. Toxicol Appl Pharmacol, 124(2): 181-90.
    • (1994) Toxicol Appl Pharmacol , vol.124 , Issue.2 , pp. 181-190
    • Timchalk, C.1    Smith, F.A.2    Bartels, M.J.3
  • 29
    • 54249084455 scopus 로고
    • Methodology for Evaluating Potential Carcinogenicity in Support of Reportable Quantity Adjustments Pursuant to CERCLA Section 102. OHEA-C-073
    • USEPA (US Environmental Protection Agency), Washington, DC, USA, Washington, DC,: Carcinogen Assessment Group, Office of Health and Environmental Assessment, EPA-600/8-89-053
    • USEPA (US Environmental Protection Agency). 1988. "Methodology for Evaluating Potential Carcinogenicity in Support of Reportable Quantity Adjustments Pursuant to CERCLA Section 102. OHEA-C-073". Washington, DC, USA: Carcinogen Assessment Group, Office of Health and Environmental Assessment. EPA-600/8-89-053
    • (1988)
  • 30
    • 0343256060 scopus 로고    scopus 로고
    • Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F
    • USEPA, Washington, DC, USA, Washington, DC
    • USEPA. 2005. "Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F". In Risk Assessment Forum Washington, DC, USA
    • (2005) Risk Assessment Forum
  • 31
    • 0023250909 scopus 로고
    • Salmonella mutagenicity tests: III. Results from testing of 255 chemicals
    • Zeiger, E, Anderson, BHaworth, S. 1987. Salmonella mutagenicity tests: III. Results from testing of 255 chemicals. Environ Mutagen, 9(Suppl 9): 1-110.
    • (1987) Environ Mutagen , vol.9 , Issue.SUPPL. 9 , pp. 1-110
    • Zeiger, E.1    Anderson, B.2    Haworth, S.3


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