Modulation of membrane bound ATPases and metabolizing enzymes against n-nitosodiethylamine (DEN) induced primary liver cancer in wistar albino rats

International Journal of Pharma and Bio Sciences

Volumn 3, Issue 2, 2012, Pages

  Langeswaran, K ^a   Jagadeesan, A J ^b   Balasubramanian, M P ^b  

^a BHARATH UNIVERSITY   (India)

^b UNIVERSITY OF MADRAS   (India)

Author keywords

Hepatocellular carcinoma (HCC); Limonin; Membrane bound ATPases; Mitochondrial TCA cycle enzymes; Nnitrosodiethylamine (DEN); Primary liver cancer

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); DIETHYLNITROSAMINE; GLYCOGEN; LIMONIN; MALATE DEHYDROGENASE; OXOGLUTARATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME REGULATION; ERYTHROCYTE MEMBRANE; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; TREATMENT RESPONSE;

ANIMALIA; RATTUS;

EID: 84869195854     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Blum, HE. Molecular therapy and prevention of liver diseases, Advances in Medical Sciences 52 (2007) pp. 29-36.
2. Anis, KV., Rajesh Kumar, NV and Kuttan, R. Inhibition of chemical carcinogenesis by biberine in rats and mice, J. Pharm. Pharmacol 53 (2001) pp.763-768.
3. Chakraborty, T., Chatterjee, A., Rana A., Dhachinamoorthi, D., Kumar, PA and Chatterjee, M. Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process, Biochim. Biophys. Acta 1772(1) (2007) pp.48-59.
4. Ramakrishnan, G., Raghavendran, HR., Vinodhkumar, R and Devaki, T. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats, Chem. Biol. Interact 161(2) (2006) pp.104-114.
5. Valko, M., Rhodes, CJ., Moncol, J., Izakovic, M and Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer, Chem. Biol. Interact 160(1) (2006) pp.1-40.
6. Ozaki, Y., Ayano, S., Inaba, N., Miyake, M., Berhow, MA. and Hasegawa, S. Limonoid glucosides in fruit, juice and processing by-products of Satsuma Mandarin (Citrus unshiu Marcov.), J. Food Sci 60 (1995) pp.186-189.
7. Fong, CH., Hasegawa, S., Herman, Z and Ou, P. Limonoid glucosides in commercial citrus juices, J. Food Sci 54 (1990) pp.1505-1506.
8. Lam, LKT., Hasegawa, S., Bergstrom, C., Lam, SH and Kenney, P. Limonin and nomilin inhibitory effects on chemicalinduced tumorigenesis. In Citrus Limonoids: Functional Chemicals in Agriculture and Foods; Berhow, MA., Hasegawa, S., Manners, GD., Eds.; American Chemical Society: Washington, DC, 2000; pp 185-200.
9. Tanaka, T. Maeda, M., Kohno, H., Murakami, M., Kagami, S., Miyake, M and Wada, K. Inhibition of azomethan-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin, Carcinogenesis 22 (2001) pp.193-198.
10. Battinelli, L., Mazzanti, G., Mengoni, F., Lichtner, M., Mastroianni, CM., Vullo, V and Saija, A. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells, Planta Med 69 (2003) pp.910-913.
11. Kurowska, E.M., Banh, C., Hasegawa, S and Manners, G. D. Regulation of apo B production in HepG2 cells by citrus limonoids. In Citrus Limonoid: Functional Chemicals in Agriculture and Foods, Berhow, M. A., Hasegawa, S., Manners, G. D., Eds., American Chemical Society: Washington, DC, 2000; pp 175-184.
12. Lam, LKT., Li, Y and Hasegawa, S. Effects of citrus limonoids on glutathione S-transferase activity in mice, J. Agric. Food Chem 37 (1989) pp.878-880.
13. Lam, LKT and Hasegawa, S. Inhibition of benzo[a]pyreneinduced forestomach neoplasia in mice by citrus limonoids, Nutr. Cancer 12 (1989) pp.43-47.
14. Miller, EG., Gonzales-Sanders, AP., Couvillon, AM., Wright, JM., Hasegawa, S and Lam, LKT. Inhibition of hamster buccal pouch carcinogenesis by limonin 17-â-D-glucopyranoside, Nutr. Cancer 17 (1992) pp.1-7.
15. Lam, LKT., Zhang, J., Hasegawa, S and Schut, HAJ. Inhibition of chemically induced carcinogenesis by citrus limonoids. In Food Phytochemicals for Cancer Prevention; Huang, MT., Osawa, CT. H., Rosen, RT., Eds.; American Chemical Society: Washington, DC, 1994; pp 209-219.
16. Lam, L. K. T., Hasegawa, S., Bergstrom, C., Lam, S. H and Kenney, P. Limonin and nomilin inhibitory effects on chemicalinduced tumorigenesis. In Citrus Limonoids Functional Chemicals in Agriculture and Foods, Berhow, M.A., Hasegawa, S., Manners, G.D., Eds., American Chemical Society: Washington, DC, 2000; pp 185-200.
17. Tanaka, T. Maeda, M., Kohno, H., Murakami, M., Kagami, S., Miyake, M and Wada, K. Inhibition of azomethan-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin, Carcinogenesis 22 (2001) pp.193-198.
18. Guthrie, N., Chambers, AF and Carroll, KK. Inhibition of MDAMB-435 estrogen receptor-negative human breast cancer cells by citrus limonoids, Proc. Am. Assoc. Cancer Res 38 (1997) pp.1113.
19. Lam, LKT., Zhang, J., Hasegawa, S and Schut, HAJ. Inhibition of chemically induced carcinogenesis by citrus limonoids. In Food Phytochemicals for Cancer Prevention; Huang, MT., Osawa, CT. H., Rosen, RT., Eds.; American Chemical Society: Washington, DC, 1994; pp 209-219.
20. Yoshiji, H., Nakae, D., Kinugasa, T., Matsuzaki, M., Denda, A and Suiji, T. Inhibitory effect of the iron deficiency on the induction of putative preneoplastic foci rat liver initiated with diethylnitrosamine and promoted by Phenobarbital, Br. J. Cancer 64 (1991) pp.839-842.
21. Morales, MA., Jabbagy, AJ and Terazi NP. Mutation affecting accumulation of glycogen neurospora, Neurospora. New. Lett 20 (1973) pp.24-25.
22. Bonting, SL. Sodium-potassium activated adenosine triphosphatase and cation transport. In: Membranes and ion transport, Eds by Bittar E.E, Wiley-Interscience, London, Vol.1, pp.257-363.
23. Hjerten, S and Pan, H. Purification and characterization of two forms of a low affinity calcium ion ATPase from erythrocyte membranes, Biochem. Biophys. Acta 728 (1983) pp.281-288.
24. 2+ ATPase activities in normal, regenerating and malignant cells, Biochem. Biophys. Acta 684 (1962) pp.67-74.
25. Brandstrup, N., Kirk, JE and Bruni C. Determination of hexokinase and phosphoglucoisomerase activities of arotic and pulmonary artery tissue in individuals of various ages, J. Gerentol 12 (1957) pp.166-171.
26. Horrrocks, JE., Ward, J and King J. A routine method for the determination of phosphoglucose isomerise activity in body fluid, J. Clin. Pathol 16 (1963) pp.248-251.
27. King, J (1965b). The phosphohydrolysases-acid and alkaline transaminase, In: Practical Clinical Enzymology, (Eds.) by Van Nostrand Co.Ltd., London. pp. 191-208.
28. Gancedo JM and Gancedo C Fructose-1,6-disphosphatase, phosphofrucokinase and glucose-6-phosphate dehydrogenase from fermenting and non-fermenting yeasts, Arch. Microbiol 76 (1971) pp.132-136.
29. King, J (1965c). The transferases-alanine ans aspartate transaminases. In: Van D, Eds, Practical Clinical Enzymology, Nostrand Company Limitied, London, pp.191-208.
30. Slater, EC and Borner WD. The effect of fluoride on the succinate oxidase system, Biochem J 52 (1952) pp.185-196.
31. Mehler, AH., Kornberg, AM., Grisolia, S and Ochoa, S. The enzymatic mechanisum of oxidation-reductions between malate or isocitrate and pyruvate, J. Biol Chem 17 (1948) 961-977.
32. Reed, LJ and Mukherjee BB (1969). α-ketoglutarate dehydrogenase complex from E.coli, In: Methods is Enzymology, Lowenstein JM, Eds Academic Press, New York, Vol.13 55-61.
33. Poon, RT., Fan, ST., Tsang, FH and Wong, J. Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective, Ann. Surg 235 (2002) pp.466-486.
34. Roberta, P., Eric, T and Poon, RT. Molecular pathways in hepatocellular carcinoma, Cancer Letters 240 (2006) pp.157-169.
35. Johnson, IT. Phytochemicals and cancer, Proceedings of the Nutrition Society 66 (2007) pp.207-215.
36. Ansari, RA., Tripathi, SC., Patnaik, GK and Dhawan, BN. Antihepatotoxic properties of picroliv an active fraction from rhizomes of Picrorhiza kurrooa, J. Ethano. Pharmaco 34 (1991) pp.61-68.
37. Bioj, B., Moreto, RD and Fairs RN. Membrane lipid fatty acid and regulation of membrane bound enzymes, Biochem. Biophys. Acta 311 (1973) pp.67.
38. Stekhoren, MA and Bonting, SL. Transport ATPases: Properties and functions, Physiological Rev 61 (1981) pp.1-76.
39. Ohta, Y., Kongo-Nishimura, M., Hayashi, T and Kishikawa, T. Effect of Orengedoku-To (Huanglian-Jie-Du-Tang) extract on disruption of hepatic antioxidant defence system in rats treated with Dgalactosamine. J. Ethanopharmacol 94 (2002) pp.323-329.
40. Benaim, G., Cervino, V., Hermoso, T., Felibert, P and Laurentin, A. Intracellular calcium homeostasis in Leishmania mexicana. Identification and characterization of a plasma membrane calmodulin-dependent Ca(2+)-ATPase, Biol Res 26(1-2) (1993) pp.141-50.
41. Tosulkao, C and Glinsukon, T (1992). Hepatic LPO in ethanol potentiated AFB1 hepatotoxicity. In: Lipid soluble antioxidants; Biochemistry and clinical applications. Ong ASH and Packer L Eds., Birkauser, Verlag. Switerland. Pp.567-574.
42. Frank, G., Wdzieczak-Bakala, J and Henrotte, JG. Modulating role of glucose on magnesium transport in rat erythrocytes. J. Nutr. Biochem 10 (1999) pp.433-437.
43. Kudryavtseva, MV., Besborodkina, NN and Kudryavtsev BN. Restoration of the glycogen-forming function of hepatocytes in rats with liver cirrhosis is facilitated by a high-carbohydrate diet, Br J Nutr 81(6) (1999) pp.473-80.
44. Baggetto, LG. Deviant energetic metabolism of glycolytic cancer cells, Biochimie 74(11) (1992) pp.959-74. Review.
45. Ebrahim, AS., Babakrishnan, K and Sakthisekaran, D. Perchloroethyleneinduced alterations in glucose metabolism and their prevention by 2-deoxy-Dglucose and vitamin E in mice, J Appl Toxicol 16(4) (1996) pp.339-48.
46. Sohal, R and Dubey, A. Mitochondria oxidative damage: hydrogen peroxide release and ageing, Free Red and Biol Medi 16 (1994) pp.621-626.
47. Bironaite, D and Ollinger, K. The hepatotoxicity of rhein involves impairment of mitochondrial functions, Chem Biol Interact 103(1) (1997) pp.35-50.
48. Sohal, RS and Weindruch, R. Oxidative stress, caloric restriction, and aging, Science 273(5271) (1996) pp.59-63.