Leukotriene B4 receptor locus gene characterisation and association studies in asthma

BMC Medical Genetics

Volumn 13, Issue , 2012, Pages

  Tulah, Asif S ^a,d   Beghé, Bianca ^b   Barton, Sheila J ^c   Holloway, John W ^c   Sayers, Ian ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Association; Asthma; Family based association test; Leukotriene; Leukotriene B4 receptor; RACE; Severity

Indexed keywords

LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR 1; LEUKOTRIENE B4 RECEPTOR 2; MESSENGER RNA; UNCLASSIFIED DRUG; CELL ADHESION MOLECULE; LEUKOTRIENE B4; LTB4R1 PROTEIN, HUMAN; LTB4R2 PROTEIN, HUMAN; NERVE PROTEIN; PRMP PROTEIN, RAT;

5' UNTRANSLATED REGION; ADOLESCENT; ADULT; ARTICLE; ASTHMA; BREATHING MUSCLE; CAUCASIAN; CELL SPECIFICITY; CHILD; DISEASE SEVERITY; EXON; FEMALE; FORCED EXPIRATORY VOLUME; GENE IDENTIFICATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PROMOTER REGION; RNA SPLICING; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SMOOTH MUSCLE FIBER; ALTERNATIVE RNA SPLICING; CHROMOSOME 14; FAMILY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; LUNG; MIDDLE AGED; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

5' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; ALTERNATIVE SPLICING; ASTHMA; CELL ADHESION MOLECULES; CHROMOSOMES, HUMAN, PAIR 14; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXONS; FAMILY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKOTRIENE B4; LINEAR MODELS; LINKAGE DISEQUILIBRIUM; LUNG; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEUKOTRIENE B4; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

MLCS; MLOWN;

EID: 84869187054     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-13-110     Document Type: Article

References (34)

1. Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987, 237(4819):1171-1176. 10.1126/science.2820055, 2820055.
2. Wenzel SE. The role of leukotrienes in asthma. Prostaglandins Leukot Essent Fatty Acids 2003, 69(2-3):145-155.
3. Montuschi P, Martello S, Felli M, Mondino C, Barnes PJ, Chiarotti M. Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children. Respir Res 2005, 6:119. 10.1186/1465-9921-6-119, 1283153, 16236169.
4. Wenzel SE. Arachidonic acid metabolites: mediators of inflammation in asthma. Pharmacotherapy 1997, 17(1 Pt 2):3S-12S.
5. Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004, 36(3):233-239. 10.1038/ng1311, 14770184.
6. Helgadottir A, Manolescu A, Helgason A, Thorleifsson G, Thorsteinsdottir U, Gudbjartsson DF, Gretarsdottir S, Magnusson KP, Gudmundsson G, Hicks A, et al. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet 2006, 38(1):68-74. 10.1038/ng1692, 16282974.
7. Holloway JW, Barton SJ, Holgate ST, Rose-Zerilli MJ, Sayers I. The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility. Allergy 2008, 63(8):1046-1053. 10.1111/j.1398-9995.2008.01667.x, 18547289.
8. Via M, De Giacomo A, Corvol H, Eng C, Seibold MA, Gillett C, Galanter J, Sen S, Tcheurekdjian H, Chapela R, et al. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Clin Exp Allergy 2010, 40(4):582-589. 2866051, 20067482.
9. Duroudier NP, Tulah AS, Sayers I. Leukotriene pathway genetics and pharmacogenetics in allergy. Allergy 2009, 64(6):823-839. 10.1111/j.1398-9995.2009.02015.x, 19416143.
10. Nilsson NE, Tryselius Y, Owman C. Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14. Biochem Biophys Res Commun 2000, 274(2):383-388. 10.1006/bbrc.2000.3153, 10913347.
11. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 2000, 192(3):421-432. 10.1084/jem.192.3.421, 2193217, 10934230.
12. Gelfand EW, Dakhama A. CD8+ T lymphocytes and leukotriene B4: novel interactions in the persistence and progression of asthma. J Allergy Clin Immunol 2006, 117(3):577-582. 10.1016/j.jaci.2005.12.1340, 16522456.
13. Sayers I, Swan C, Hall IP. The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells. Eur J Pharmacol 2006, 531(1-3):9-12.
14. Stewart CE, Sayers I. Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells. BMC Mol Biol 2009, 10:75. 10.1186/1471-2199-10-75, 2724484, 19638192.
15. Wadsworth SJ, Nijmeh HS, Hall IP. Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model. J Clin Immunol 2006, 26(4):376-387. 10.1007/s10875-006-9029-z, 16786432.
16. Swan C, Richards SA, Duroudier NP, Sayers I, Hall IP. Alternative promoter use and splice variation in the human histamine H1 receptor gene. Am J Respir Cell Mol Biol 2006, 35(1):118-126. 10.1165/rcmb.2005-0408OC, 16484687.
17. Barton SJ, Koppelman GH, Vonk JM, Browning CA, Nolte IM, Stewart CE, Bainbridge S, Mutch S, Rose-Zerilli MJ, Postma DS, et al. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. J Allergy Clin Immunol 2009, 123(6):1391-1400. e1317, 10.1016/j.jaci.2009.03.014, 19443020.
18. Beghe B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri LM, Ruse C, Sayers I. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 2009, 65(4):474-481.
19. BTS British guidelines on the management of asthma. Thorax 2008, 63(4):iv1-iv121. BTS.
20. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265. 10.1093/bioinformatics/bth457, 15297300.
21. Bevan S, Dichgans M, Wiechmann HE, Gschwendtner A, Meitinger T, Markus HS. Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations. Stroke 2008, 39(4):1109-1114. 10.1161/STROKEAHA.107.491969, 18323512.
22. Yuan HY, Chiou JJ, Tseng WH, Liu CH, Liu CK, Lin YJ, Wang HH, Yao A, Chen YT, Hsu CN. FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res 2006, 34:W635-W641. Web Server issue, 10.1093/nar/gkl236, 1538865, 16845089.
23. Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001, 9(4):301-306. 10.1038/sj.ejhg.5200625, 11313775.
24. Wenzel SE, Szefler SJ, Leung DY, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997, 156(3 Pt 1):737-743.
25. Medoff BD, Tager AM, Jackobek R, Means TK, Wang L, Luster AD. Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1. Am J Physiol Lung Cell Mol Physiol 2006, 290(1):L170-L178.
26. Taube C, Miyahara N, Ott V, Swanson B, Takeda K, Loader J, Shultz LD, Tager AM, Luster AD, Dakhama A, et al. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol 2006, 176(5):3157-3164.
27. Evans DJ, Barnes PJ, Spaethe SM, van Alstyne EL, Mitchell MI, O'Connor BJ. Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma. Thorax 1996, 51(12):1178-1184. 10.1136/thx.51.12.1178, 472760, 8994512.
28. Watanabe S, Yamasaki A, Hashimoto K, Shigeoka Y, Chikumi H, Hasegawa Y, Sumikawa T, Takata M, Okazaki R, Watanabe M, et al. Expression of functional leukotriene B4 receptors on human airway smooth muscle cells. J Allergy Clin Immunol 2009, 124(1):59-65. e51-53, 10.1016/j.jaci.2009.03.024, 19477492.
29. Kato K, Yokomizo T, Izumi T, Shimizu T. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J Exp Med 2000, 192(3):413-420. 10.1084/jem.192.3.413, 2193224, 10934229.
30. Gentles AJ, Karlin S. Why are human G-protein-coupled receptors predominantly intronless?. Trends Genet 1999, 15(2):47-49. 10.1016/S0168-9525(98)01648-5, 10098406.
31. Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med 1995, 182(6):1951-1958. 10.1084/jem.182.6.1951, 2192226, 7500041.
32. Kochetov AV, Ischenko IV, Vorobiev DG, Kel AE, Babenko VN, Kisselev LL, Kolchanov NA. Eukaryotic mRNAs encoding abundant and scarce proteins are statistically dissimilar in many structural features. FEBS Lett 1998, 440(3):351-355. 10.1016/S0014-5793(98)01482-3, 9872401.
33. Iida A, Saito S, Sekine A, Takahashi A, Kamatani N, Nakamura Y. Japanese single nucleotide polymorphism database for 267 possible drug-related genes. Cancer Sci 2006, 97(1):16-24. 10.1111/j.1349-7006.2006.00142.x, 16367916.
34. Bevan S, Lorenz MW, Sitzer M, Markus HS. Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study. Stroke 2009, 40(3):696-701. 10.1161/STROKEAHA.108.525733, 19131661.