Replacement of acetonitrile by mixtures of propylene carbonate and methanol as organic modifier in mobile phases for RPLC separation mechanism: Application to the assay of alprazolam and sertraline in combined pharmaceutical formulations

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 18, 2012, Pages 2643-2654

  Varsha, Namboodiry ^a   Suvarna, Bhoir ^b   Pratibha, Verma ^a   Soni, Mishra ^a   Ashok, Bhagwat ^b  

^a NMIMS UNIVERSITY   (India)

^b CB Patel Research Centre   (India)

Author keywords

acetonitrile; alprazolam; propylene carbonate; RPLC; sertraline; Solvent X

Indexed keywords

ALPRAZOLAM; PROPYLENE CARBONATE; RPLC; SERTRALINE; SOLVENT-X;

ACETONITRILE; BIODEGRADATION; DRUG PRODUCTS; METHANOL; SOLVENTS;

ORGANIC SOLVENTS;

ACETONITRILE; ALPRAZOLAM; METHANOL; PROPYLENE CARBONATE; SERTRALINE;

ARTICLE; BIODEGRADABILITY; DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG FORMULATION; LIMIT OF DETECTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84869164923     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.637273     Document Type: Article

References (33)

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31. Patel, R. B.;, Patel, M. R.;, Shankar, M. B.;, Bhatt, K. K. Development and Validation of Second-Derivative Spectrophotometry Method for Simultaneous Estimation of Alprazolam and Fluoxetine Hydrochloride in Pure Powder and Tablet Formulation and Its Comparison with HPLC Method. Eurasian J. Anal. Chem. 2009, 4 (1), 76-86.
32. Farshchi, A., Ghiasia, G.;, Bahramia, G. High Performance Liquid Chromatography Determination of Sertraline in Human. IJPS Summer 2009, 5 (3), 171-178.
33. Reduced Solvent Consumption and Operational Costs, Shimadzu Corporation, http://www.shimadzu.com/an/hplc/support/faq/acetonitrile/5.html Accessed April 23, 2011.