Training old rats selectively modulates synaptosomal protein synthesis

Journal of Neuroscience Research

Volumn 91, Issue 1, 2013, Pages 20-29

  Eyman, Maria ^a   Cefaliello, Carolina ^a   Mandile, Paola ^a   Piscopo, Stefania ^a,b   Crispino, Marianna ^a   Giuditta, Antonio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

Author keywords

Brain plasticity; Learning; Old rats; Protein synthesis; Synaptosomes

Indexed keywords

NERVE PROTEIN; SYNAPTIC PROTEIN; UNCLASSIFIED DRUG;

AGED; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN CORTEX; BRAIN STEM; CONTROLLED STUDY; ESCAPE BEHAVIOR; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

AGING; ANIMALS; BRAIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; LEARNING; MALE; NEURONAL PLASTICITY; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOSOMES;

EID: 84869156635     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23133     Document Type: Article

References (23)

1. Ambrosini MV, Giuditta A. 2001. Learning and sleep: the sequential hypothesis. Sleep Med Rev 5: 477-490.
2. Ambrosini MV, Mariucci G, Bruschelli G, Colarieti L, Giuditta A. 1995. Sequential hypothesis of sleep function. V. Lengthening of post-trial SS episodes in reminiscent rats. Physiol Behav 58: 1043-1049.
3. 14C-labeled leucine into synaptosomes from rat cerebral cortex in vitro. J Neurochem 14: 377-387.
4. Casadio A, Martin KC, Giustetto M, Zhu H, Chen M, Bartsch D, Bailey CH, Kandel ER. 1999. A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99: 221-237.
5. Cotman CW, Taylor D. 1972. Isolation and structural studies on synaptic complexes from rat brain. J Cell Biol 55: 696-711.
6. Crispino M, Castigli E, Perrone Capano C, Martin R, Menichini E, Kaplan BB, Giuditta A. 1993. Protein synthesis in a synaptosomal fraction from squid brain. Mol Cell Neurosci 4: 366-374.
7. Crispino M, Cefaliello C, Kaplan BB, Giuditta A. 2009. Protein synthesis in nerve terminals and the glia-neuron unit. Results Probl Cell Differ 48: 243-267.
8. Eyman M, Cefaliello C, Ferrara E, De Stefano R, Scotto Lavina Z, Crispino M, Squillace A, van Minnen J, Kaplan BB, Giuditta A. 2007a. Local synthesis of axonal and presynaptic RNA in squid model systems. Eur J Neurosci 25: 341-350.
9. Eyman M, Cefaliello C, Ferrara E, Mandile P, Crispino M, Giuditta A. 2007b. Synaptosomal protein synthesis from rat brain is selectively modulated by learning. Brain Res 1132: 148-157.
10. Eyman M, Cefaliello C, Bruno AP, Crispino M, Giuditta A. 2012. Synaptosomal protein synthesis in P2 and Ficoll purified brain fractions. J Neurosci Methods 203: 335-337.
11. Gambetti P, Autilio-Gambetti LA, Gonatas NK, Shafer B. 1972. Protein synthesis in synaptosomal fractions. Ultrastructural radioautographic study. J Cell Biol 52: 526-535.
12. Giuditta A, Kaplan BB, van Minnen J, Alvarez J, Koenig E. 2002. Axonal and presynaptic protein synthesis: new insights into the biology of the neuron. Trends Neurosci 25: 400-404.
13. Giuditta A, Chun JT, Eyman M, Cefaliello C, Bruno AP, Crispino M. 2007. Axonal and presynaptic RNAs are locally transcribed in glial cells. Riv Biol 100: 203-220.
14. Giuditta A, Chun JT, Eyman M, Cefaliello C, Crispino M. 2008. Local gene expression in axons and nerve endings: the glia-neuron unit. Physiol Rev 88: 515-555.
15. Henn FA, Anderson DJ, Rustad DG. 1976. Glial contamination of synaptosomal fractions. Brain Res 101: 341-344.
16. Kang H, Schuman EM. 1995. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267: 1658-1662.
17. Mariucci G, Giuditta A, Ambrosini MV. 2007. Permanent brain ischemia induces marked increments in hsp72 expression and local protein synthesis in synapses of the ischemic hemisphere. Neurosci Lett 415: 77-80.
18. Martin KC, Casadio A, Zhu H, Yaping E, Rose JC, Chen M, Bailey CH, Kandel ER. 1997. Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91: 927-938.
19. Morgado-Bernal I. 2011. Learning and memory consolidation: linking molecular and behavioral data. Neuroscience 176: 12-19.
20. Nadel L, Hupbach A, Gomez R, Newman-Smith K. 2012. Memory formation, consolidation and transformation. Neurosci Biobehav Rev 36: 1640-1645.
21. Rao A, Steward O. 1991. Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes. J Neurosci 11: 2881-2895.
22. Schacher S, Wu F. 2002. Synapse formation in the absence of cell bodies requires protein synthesis. Neuroscience 22: 1831-1839.
23. Steward O, Schuman EM. 2003. Compartmentalized synthesis and degradation of proteins in neurons. Neuron 40: 347-359.