Androgen replacement therapy improves psychological distress and health-related quality of life in late onset hypogonadism patients in Chinese population

Chinese Medical Journal

Volumn 125, Issue 21, 2012, Pages 3806-3810

  Zhang, Xiao wei ^a   Liu, Zhen hua ^a   Hu, Xiao wei ^b   Yuan, Ye qing ^a   Bai, Wen jun ^a   Wang, Xiao feng ^a   Shen, Huan ^a   Zhao, Yong ping ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Androgen replacement therapy; Late onset hypogonadism; Psychological distress

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; TESTOSTERONE; TESTOSTERONE UNDECANOATE;

ADULT; AGED; AGING MALE SYMPTOM RATING SCALE; ANDROGEN THERAPY; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEPRESSION; DISTRESS SYNDROME; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; HYPOGONADISM; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; PERCEIVED STRESS SCALE; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SHORT FORM 12; SINGLE BLIND PROCEDURE;

AGE OF ONSET; AGED; ANXIETY; DEPRESSION; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOGONADISM; MALE; MIDDLE AGED; QUALITY OF LIFE; SINGLE-BLIND METHOD; TESTOSTERONE;

EID: 84869147825     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2012.21.011     Document Type: Article

References (26)

1. Gray A, Berlin JA, McKinlay JB, Longcope C. An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J Clin Epidemiol 1991; 44: 671-684.
2. Morley JE. Endocrine factors in geriatric sexuality. Clin Geriatr Med 1991; 7: 85-93.
3. Lunenfeld B, Nieschlag E. Testosterone therapy in the aging male. Aging Male 2007; 10: 139-153.
4. Morley JE. Testosterone replacement in older men and women. J Gend Specif Med 2001; 4: 49-53.
5. Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabol Clin Exp 2000; 49: 1239-1242.
6. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations. J Androl 2009; 30: 1-9.
7. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010; 95: 2536-2559.
8. Chu LW, Tam S, Kung AWC, Lam TP, Lee A, Wong RL. Validation of the ADAM questionnaire for androgen deficiency in aging Chinese men. J Gerontology Med Sci 2008; 63: 426-431.
9. Chu LW, Tam S, Kung AW, Lo S, Fan S, Wong RL, et al. Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men. J Am Geriatric Society 2008; 56: 1286-1291.
10. Heinemann LA, Saad F, Zimmermann T, Novak A, Myon E, Badia X, et al. The Aging Males' Symptoms (AMS) scale: update and compilation of international versions. Health Qual Life Outcomes 2003; 1: 15.
11. Leung CM, Ho S, Kao CS, Hung CN, Chen CN. Evaluation of the Chinese version of the Hospital Anxiety and Depression Scale: a cross-cultural perspective. Int J Psychosom 1992; 40: 29-34.
12. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361-370.
13. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983; 24: 385-396.
14. Burt CE, Cohen LH, Bjorck JP. Perceived family environment as a moderator of young adolescents' life stress adjustment. Am J Community Psychol 1988; 16: 101-122.
15. Ware JE, Kosinski M, Keller SD. How to score the SF-12 physical and mental health summary scales, 2nd ed. Boston: The Health Institute, New England Medical Center; 1995.
16. Lam CLK, Gandek B. Cross-cultural adaptation of the SF-36 and SF-12 physical and mental summary scales on a Chinese population. Qual Life Res 2001; 10: 283.
17. Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabol Clin Exp 2000; 49:1239-1242.
18. Li JY, Li XY, Li M, Zhang GK, Ma FL, Liu ZM, et al. Decline of serum levels of free testosterone in aging healthy Chinese men. Aging Male 2005; 8: 203-206.
19. Seidman SN. Testosterone deficiency and depression in aging men: pathogenic and therapeutic implications. J Gend Specif Med 2001; 4: 44-48.
20. Ehrenreich H, Halaris A, Ruether E, Hufner M, Funke M, Kunert HJ. Psychoendocrine sequelae of chronic testosterone deficiency. J Psychiatr Res 1999; 33: 379-387.
21. Heuser I, Hartmann A, Oertel H. Androgen replacement in a 48, XXYY-male patient. Arch Gen Psychiatry 1999; 56: 194-195.
22. Seidman SN, Rabkin JG. Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression. J Affect Disord 1998; 48: 157-161.
23. Rabkin JG, Wagner GJ, Rabkin R. Testosterone therapy for human immunodeficiency virus-positive men with and without hypogonadism. J Clin Psychopharmacol 1999; 19: 19-27.
24. Grinspoon S, Corcoran C, Stanley T, Baaj A, Basgoz N, Klibanski A. Effects of hypogonadism and testosterone administration on depression indices in HIV-infected men. J Clin Endocrinol Metab 2000; 85: 60-65.
25. Sugimori H, Yoshida K, Tanaka T, Baba K, Nishida T, Nakazawa R, et al. Relationships between erectile dysfunction, depression, and anxiety in Japanese subjects. J Sex Med 2005; 2: 390-396.
26. Legros JJ, Meuleman EJ, Elbers JM, Geurts TB, Kaspers MJ, Bouloux PM. Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study. Eur J Endocrinol 2009; 160: 821-831.