Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 5, 2012, Pages

  MacGlashan Jr , Donald W ^a   Savage, Jessica H ^a   Wood, Robert A ^a   Saini, Sarbjit S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

anti IgE; Basophil; IgE receptor; peanut; spleen tyrosine kinase

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; OMALIZUMAB;

ARTICLE; BASOPHIL; CLINICAL ARTICLE; DRUG EFFECT; DRUG RESPONSE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; PEANUT ALLERGY; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 84869121372     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.05.038     Document Type: Article

References (22)

1. J.A. Eckman, P.M. Sterba, D. Kelly, V. Alexander, M.C. Liu, and B.S. Bochner Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge J Allergy Clin Immunol 125 2010 889 895 e7
2. J.H. Savage, J.-P. Courneya, P.M. Sterba, D.W. MacGlashan, S.S. Saini, and R.A. Wood Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy J Allergy Clin Immunol 130 2012 1123 1129
3. A.K. Zaidi, S.S. Saini, and D.W. Macglashan Jr. Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab J Allergy Clin Immunol 125 2010 902 908 e7
4. S.S. Ishmael, and D.W. MacGlashan Jr. Syk expression in peripheral blood leukocytes, CD34+ progenitors, and CD34-derived basophils J Leukoc Biol 87 2010 291 300
5. R.P. Siraganian An automated continuous-flow system for the extraction and fluorometric analysis of histamine Anal Biochem 57 1974 383 394
6. D.W. MacGlashan Jr. Relationship between Syk and SHIP expression and secretion from human basophils in the general population J Allergy Clin Immunol 119 2007 626 633
7. A. Nopp, S.G. Johansson, J. Ankerst, G. Bylin, L.O. Cardell, and R. Gronneberg Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluation Allergy 61 2006 298 302 (Pubitemid 43381805)
8. M. Dembo, B. Goldstein, A.K. Sobotka, and L.M. Lichtenstein Histamine release due to bivalent penicilloyl haptens: control by the number of cross-linked IgE antibodies on the basophil plasma membrane J Immunol 121 1978 354 358 (Pubitemid 8384889)
9. B. Goldstein, M. Dembo, A.K. Sobotka, and L.M. Lichtenstein Some invariant properties of IgE-mediated basophil activation and desensitization J Immunol 123 1979 1873 1882 (Pubitemid 10229574)
10. D.W. MacGlashan Jr., M. Dembo, and B. Goldstein Test of a theory relating to the cross-linking of IgE antibody on the surface of human basophils J Immunol 135 1985 4129 4134 (Pubitemid 16250402)
11. S. Ishmael, and D. MacGlashan Jr. Early signal protein expression profiles in basophils: a population study J Leukoc Biol 86 2009 313 325
12. D.W. MacGlashan Jr. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables J Allergy Clin Immunol 91 1993 605 615
13. S.J. Arbes Jr., P.J. Gergen, L. Elliott, and D.C. Zeldin Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey J Allergy Clin Immunol 116 2005 377 383 (Pubitemid 41096546)
14. A. Nopp, S.G. Johansson, J. Ankerst, M. Palmqvist, and H. Oman CD-sens and clinical changes during withdrawal of Xolair after 6 years of treatment Allergy 62 2007 1175 1181 (Pubitemid 47374025)
15. A. Nopp, L.O. Cardell, S.G. Johansson, and H. Oman CD-sens: a biological measure of immunological changes stimulated by ASIT Allergy 64 2009 811 814
16. J.J. Pruzansky, L.C. Grammer, R. Patterson, and M. Roberts Dissociation of IgE from receptors on human basophils. I. Enhanced passive sensitization for histamine release J Immunol 131 1983 1949 1953 (Pubitemid 13007845)
17. D.W. MacGlashan Jr. Endocytosis, re-cycling and degradation of unoccupied FcεRI in human basophils J Leukoc Biol 82 2007 1003 1010
18. D.W. MacGlashan Jr., S. Ishmael, S.M. Macdonald, J.M. Langdon, J.P. Arm, and D.E. Sloane Induced loss of Syk in human basophils by non-IgE-dependent stimuli J Immunol 180 2008 4208 4217
19. S. Ishmael, and D.W. MacGlashan Jr. Early signal protein expression profiles in basophils: a population study J Leukoc Biol 86 2009 313 325
20. J.A. Eckman, P.M. Sterba, D. Kelly, V. Alexander, M.C. Liu, and B.S. Bochner Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge J Allergy Clin Immunol 125 2010 889 895 e7
21. D.W. MacGlashan Jr. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables J Allergy Clin Immunol 91 1993 605 615
22. D.W. MacGlashan Jr., and L.M. Lichtenstein Studies of antigen binding on human basophils. I. Antigen binding and functional consequences J Immunol 130 1983 2330 2336 (Pubitemid 13086781)