Tracking brain amyloid-β in presymptomatic Alzheimer's disease

The Lancet Neurology

Volumn 11, Issue 12, 2012, Pages 1018-1020

  Jagust, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; FLORBETAPIR F 18; PITTSBURGH COMPOUND B;

ALZHEIMER DISEASE; ASYMPTOMATIC DISEASE; AUTOSOMAL DOMINANT DISORDER; BRAIN ATROPHY; BRAIN DEGENERATION; CEREBROSPINAL FLUID; CLINICAL TRIAL (TOPIC); COGNITION; COGNITIVE DEFECT; GENE MUTATION; HUMAN; LETTER; NERVE DEGENERATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STEREOTYPY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANILINE COMPOUNDS; ETHYLENE GLYCOLS; FEMALE; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PRESENILIN-1;

EID: 84869116234     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(12)70255-7     Document Type: Letter

References (7)

1. Hardy J, Selkoe DJ The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
2. Villemagne VL, Pike KE, Chetelat G, et al. Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease. Ann Neurol 2011, 69:181-192.
3. Fleisher AS, Chen K, Quiroz YT, et al. Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study. Lancet Neurol 2012, published online Nov 6. http://dx.doi.org/10.1016/S1474-4422(12)70227-2.
4. Bateman RJ, Xiong C, Benzinger TL, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012, 367:795-804.
5. Reiman EM, Quiroz YT, Fleisher AS, et al. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol 2012, published online Nov 6. http://dx.doi.org/10.1016/S1474-4422(12)70228-4.
6. Jack CR, Knopman DS, Jagust WJ, et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010, 9:119-128.
7. Castellano JM, Kim J, Stewart FR, et al. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Transl Med 2011, 3:89ra57.