The Fas apoptotic pathway in cutaneous T-cell lymphomas: Frequent expression of phenotypes associated with resistance to apoptosis

Journal of the American Academy of Dermatology

Volumn 67, Issue 6, 2012, Pages 1327.e1-1327.e10

  Stutz, Nathalie ^a   Johnson, Ryan D ^b   Wood, Gary S ^a,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

anaplastic large cell lymphoma; apoptosis; caspases; extrinsic apoptotic pathway; Fas; Fas ligand; Fas associated death domain; FLICE like inhibitory protein; lymphomatoid papulosis; mycosis fungoides

Indexed keywords

CASPASE 3; CASPASE 8; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN;

ADOLESCENT; ADULT; AGED; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOMA CELL; LYMPHOMATOID PAPULOSIS; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; MYCOSIS FUNGOIDES; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SKIN BIOPSY;

EID: 84869115336     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2012.05.035     Document Type: Article

References (18)

1. R. Dummer, S.A. Michie, D. Kell, J.W. Gould, A.C. Haeffner, and B.R. Smoller Expression of bcl-2 protein and Ki-67 nuclear proliferation antigen in benign and malignant cutaneous T-cell infiltrates J Cutan Pathol 22 1995 11 17
2. H. Nevala, L. Karenko, L. Vakeva, and A. Ranki Proapoptotic and antiapoptotic markers in cutaneous T-cell lymphoma skin infiltrates and lymphomatoid papulosis Br J Dermatol 145 2001 928 937
3. T.M. Kuzel Systemic chemotherapy for the treatment of mycosis fungoides and Sezary syndrome Dermatol Ther 16 2003 355 361
4. R. Willemze, E.S. Jaffe, G. Burg, L. Cerroni, E. Berti, and S.H. Swerdlow WHO-EORTC classification for cutaneous lymphomas Blood 105 2005 3768 3785
5. P.H. Krammer, R. Arnold, and I.N. Lavrik Life and death in peripheral T cells Nat Rev Immunol 7 2007 532 542
6. J. Wu, M. Nihal, J. Siddiqui, E.C. Vonderheid, and G.S. Wood Low FAS/CD95 expression by CTCL correlates with reduced sensitivity to apoptosis that can be restored by FAS upregulation J Invest Dermatol 129 2009 1165 1173
7. F.K. Braun, L.F. Fecker, C. Schwarz, P. Walden, C. Assaf, and H. Durkop Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells J Invest Dermatol 127 2007 2425 2437
8. E. Contassot, K. Kerl, S. Roques, R. Shane, O. Gaide, and M. Dupuis Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression Blood 111 2008 4780 4787
9. G.S. Wood, C.F. Crooks, and A.Z. Uluer Lymphomatoid papulosis and associated cutaneous lymphoproliferative disorders exhibit a common clonal origin J Invest Dermatol 105 1995 51 55
10. O. Zoi-Toli, M.H. Vermeer, E. De Vries, P. Van Beek, C.J. Meijer, and R. Willemze Expression of Fas and Fas-ligand in primary cutaneous T-cell lymphoma (CTCL): association between lack of Fas expression and aggressive types of CTCL Br J Dermatol 143 2000 313 319
11. J.E. Sigel, and E.D. Hsi Immunohistochemical analysis of CD30-positive lymphoproliferative disorders for expression of CD95 and CD95L Mod Pathol 13 2000 446 451
12. + lymphoproliferative disorders: expression of bcl-2 and proteins of the tumor necrosis factor receptor superfamily Hum Pathol 29 1998 1223 1230
13. L. Xerri, N. Carbuccia, P. Parc, J. Hassoun, and F. Birg Frequent expression of FAS/APO-1 in Hodgkin's disease and anaplastic large cell lymphomas Histopathology 27 1995 235 241
14. I.S. van Houdt, J.J. Muris, A.T. Hesselink, D. Kramer, S.A. Cillessen, and L.M. Moesbergen Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin's lymphoma and correlates with lack of caspase 8 activation Histopathology 51 2007 778 784
15. J. Wu, and G.S. Wood Reduction of Fas/CD95 promoter methylation, upregulation of Fas protein, and enhancement of sensitivity to apoptosis in cutaneous T-cell lymphoma Arch Dermatol 147 2011 443 449
16. A. Aviles, M.J. Nambo, N. Neri, C. Castaneda, S. Cleto, and M. Gonzalez Interferon and low dose methotrexate improve outcome in refractory mycosis fungoides/Sezary syndrome Cancer Biother Radiopharm 22 2007 836 840
17. B. Hirsch, F.K. Braun, N. Al-Yacoub, C. Assaf, M.E. Kadin, and W. Sterry cFLIP diminishes CD95-induced apoptosis of CD30-stimulated cutaneous anaplastic large T cell lymphoma (cALCL) cells [in German] Pathologe 31 Suppl 2010 193 198
18. M.P. Oyarzo, L.J. Medeiros, C. Atwell, M. Feretzaki, V. Leventaki, and E. Drakos c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma Blood 107 2006 2544 2547