Diagnostic and prognostic performance of a novel high-sensitivity cardiac troponin T assay compared to a contemporary sensitive cardiac troponin I assay in patients with acute coronary syndrome

Clinical Research in Cardiology

Volumn 101, Issue 10, 2012, Pages 837-845

  Mueller, M ^a   Celik, S ^a   Biener, M ^a   Vafaie, M ^a   Schwoebel, K ^a   Wollert, K C ^b   Januzzi, J L ^c   Katus, H A ^a   Giannitsis, E ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acute coronary syndrome; Early diagnosis; High sensitivity troponin; Prognosis

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; AGED; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; EARLY DIAGNOSIS; FEMALE; GLOMERULUS FILTRATION RATE; HEART DEATH; HEART INFARCTION; HIGH SENSITIVITY CARDIAC TROPONIN T ASSAY; HUMAN; HUMAN TISSUE; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; NONCARDIAC CHEST PAIN; PERFORMANCE; PREDICTIVE VALUE; PROGNOSIS; PROTEIN DETERMINATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THORAX PAIN; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; AGED; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TROPONIN T;

EID: 84869108301     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-012-0469-6     Document Type: Article

References (23)

1. Thygesen K, Alpert JS, White HD et al (2007) Universal definition of myocardial infarction. Circulation 116:2634-2653
2. Apple FS, Smith SW, Pearce LA et al (2008) Use of the Centaur TnI-Ultra assay for detection of myocardial infarction and adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. Clin Chem 54:723-728
3. Venge P, James S, Jansson L et al (2009) Clinical performance of two highly sensitive cardiac troponin I assays. Clin Chem 55:109-116
4. Keller T, Zeller T, Peetz D et al (2009) Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 361:868-877
5. Reichlin T, Hochholzer W, Bassetti S et al (2009) Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 361:858-867
6. Apple FS (2009) A new season for cardiac troponin assays: It's time to keep a scorecard. Clin Chem 55:1303-1306
7. Prontera C, Fortunato A, Storti S et al (2007) Evaluation of analytical performance of the Siemens ADVIA TnI ultra immunoassay. Clin Chem 53:1722-1723
8. Giannitsis E, Kurz K, Hallermayer K et al (2010) Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 56:254-261
9. Giannitsis E, Katus HA (2009) Troponins and high-sensitivity troponins as markers of necrosis in CAD and heart failure. Herz 34:600-606
10. Celik S, Giannitsis E, Wollert KC et al (2011) Cardiac troponin T concentrations above the 99th percentile value as measured by a new high-sensitivity assay predict long-term prognosis in patients with acute coronary syndromes undergoing routine early invasive strategy. Clin Res Cardiol 100:1077-1085
11. James S, Armstrong P, Califf R et al (2003) Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: Prospective verification in the GUSTO-IV trial. Am J Med 115:178-184
12. Eggers KM, Jaffe AS, Lind L et al (2009) Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making. Clin Chem 55:85-92
13. Lindahl B, Diderholm E, Lagerqvist B et al (2001) Mechanisms behind the prognostic value of troponin T in unstable coronary artery disease: A FRISC II substudy. J Am Coll Cardiol 38:979-986
14. Morrow DA, Rifai N, Sabatine MS et al (2003) Evaluation of the AccuTnI cardiac troponin I assay for risk assessment in acute coronary syndromes. Clin Chem 49:1396-1398
15. Venge P, Lagerqvist B, Diderholm E et al (2002) Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy). Am J Cardiol 89:1035-1041
16. Kontos MC, Shah R, Fritz LM et al (2004) Implication of different cardiac troponin I levels for clinical outcomes and prognosis of acute chest pain patients. J Am Coll Cardiol 43:958-965
17. Morrow DA, Cannon CP, Rifai N et al (2001) Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: Results from a randomized trial. JAMA 286:2405-2412
18. Kastrati A, Mehilli J, Neumann FJ et al (2006) Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: The ISARREACT 2 randomized trial. JAMA 295:1531-1538
19. Venge P, Johnston N, Lindahl B et al (2009) Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia. J Am Coll Cardiol 54:1165-1172
20. Kavsak PA, Wang X, Ko DT et al (2009) Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population. Clin Chem 55:1809-1815
21. Melanson SE, Morrow DA, Jarolim P (2007) Earlier detection of myocardial injury in a preliminary evaluation using a new troponin I assay with improved sensitivity. Am J Clin Pathol 128:282-286
22. Giannitsis E, Becker M, Kurz K et al (2010) High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem 56:642-650
23. Mueller M, Biener M, Vafaie M et al (2012) Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 58:209-218