Fecal calprotectin as a correlative marker in clinical severity of infectious diarrhea and usefulness in evaluating bacterial or viral pathogens in children

Journal of Pediatric Gastroenterology and Nutrition

Volumn 55, Issue 5, 2012, Pages 541-547

  Chen, Chien Chang ^a   Huang, Jing Long ^a   Chang, Chee Jen ^b   Kong, Man Shan ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Calprotectin; Diarrhea; Generalized estimating equations

Indexed keywords

CALGRANULIN;

ADENOVIRUS INFECTION; ARTICLE; CAMPYLOBACTERIOSIS; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ACTIVITY; DISEASE MARKER; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; FEMALE; HUMAN; INFANT; INFECTIOUS DIARRHEA; MAJOR CLINICAL STUDY; MALE; NOROVIRUS INFECTION; PRESCHOOL CHILD; PRIORITY JOURNAL; ROTAVIRUS INFECTION; SALMONELLOSIS; SCHOOL CHILD; SCORING SYSTEM;

ADENOVIRIDAE; BIOLOGICAL MARKERS; CAMPYLOBACTER; CHILD; CHILD, PRESCHOOL; DIARRHEA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FECES; FEMALE; HUMANS; INFANT; INFECTION; INFLAMMATORY BOWEL DISEASES; INTESTINES; LEUKOCYTE L1 ANTIGEN COMPLEX; LINEAR MODELS; MALE; NOROVIRUS; ROTAVIRUS; SALMONELLA; SEVERITY OF ILLNESS INDEX;

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); CAMPYLOBACTER; NOROVIRUS; ROTAVIRUS; SALMONELLA;

EID: 84869097466     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e318262a718     Document Type: Article

References (32)

1. Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull WHO 2003;81:197-204.
2. Olesen B, Neimann J, Bottiger B, et al. Etiology of diarrhea in young children in Denmark: A case-control study. J Clin Microbiol 2005;43:3636-41.
3. Chen SM, Ni YH, Chen HL, et al. Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan. J Formos Med Assoc 2006;105:964-70.
4. Larrosa-Haro A, Macias-Rosales R, Sanchez-Ramirez CA, et al. Seasonal variation of eneropathogens in infants and preschoolers with acute diarrhea in western Mexico. J Pediatr Gastroenterol Nutr 2010;51:534-6.
5. Huhulescu S, Kiss R, Brettlecker M, et al. Etiology of acute gastroenteritis in three sentinel general practices, Australia 2007. Infection 2009;37:103-8.
6. van Duynhoven YT, de Jager CM, Kortbeek LM, et al. A one-year intensified study of outbreaks of gastroenteritis in the Netherlands. Epidemiol Infect 2005;133:9-21.
7. Chen SY, Chang YC, Lee YS, et al. Molecular epidemiology and clinical manifestations of viral gastroenteritis in hospitalized pediatric patients in northern Taiwan. J Clin Microbiol 2007;45:2054-7.
8. Olafsdottir E, Aksnes L, Fluge G, et al. Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children. Acta Paediatr 2002;91:45-50.
9. Langhorst J, Elsenbruch S, Koelzer J, et al. Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel disease: Performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP and clinical indices. Am J Gastroenterol 2008;108:162-9.
10. Naughton PJ, Clohessy PA, Grant G, et al. Faecal calprotectin: Noninvasive marker of gastrointestinal inflammation in Salmonella infected rats. Biochem Soc Trans 1996;24:308S.
11. Poullis A, Foster R, Northfield TC, et al. Faecal markers in the assessment of activity in inflammatory bowel disease. Aliment Pharmacol Ther 2002;16:675-81.
12. Ruuska T, Vesikari T. Rotavirus disease in Finnish children: Use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis 1990;22:259-67.
13. Fagerberg UL, Loof L, Myrdal U, et al. Colorectal inflammation is well predicted by fecal calprotectin in children with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr 2005;40:450-5.
14. Hardin JW, Hilbe JM. Generalized Estimating Equations. 2nd ed. Boca Raton, FL: Chapman & Hall/CRC; 2003.
15. Poullis A, Foster R, Mendall MA, et al. Emerging role of calprotectin in gastroenterology. J Gastroenterol Hepatol 2003;18:756-62.
16. Bunn SK, Bisset M, Main MJC, et al. Fecal calprotectin as a marker of gastrointestinal inflammation during the first year of life. J Pediatr Gastroenterol Nutr 2000;31(suppl 2):43.
17. Fagerhol MK. Nomenclature for proteins: Is calprotectin a proper name for the elusive myelomonocytic protein? J Clin Pathol Mol Pathol 1996;49:74-9.
18. Naughton PJ, Grant G, Spencer RJ, et al. A rat model of infection by Salmonella typhimurium or Salmonella enteritidis. J Appl Bacteriol 1996;81:651-6.
19. Palimood AB, Mathan MM, Mathan VI. Quantitative and ultrastructural analysis of rectal mucosal mast cells in acute infective diarrhea. Dig Dis Sci 1998;43:2111-6.
20. Conlan JW, North RJ. Early pathogenesis of infection in the liver with the facultative intracellular bacteria Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium involves lysis of infected hepatocytes by leukocytes. Infect Immun 1992;60:5164-71.
21. Perdomo JJ, Gounon P, Sansonetti PJ. Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri. J Clin Invest 1994;93:633-43.
22. Roseth AG, Aadland E, Jahnsen J, et al. Assessment of disease activity in ulcerative colitis by faecal calprotectin, a novel granulocyte marker protein. Digestion 1997;58:176-80.
23. Bunn SK, Bisset WM, Main MJ, et al. Fecal calprotectin: validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001;33:14-22.
24. Tibble JA, Sigthorsson G, Bridger S, et al. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology 2000;119:15-22.
25. Roseth AG, Fagerhol MK, Aadland E, et al. Assessment of the neutrophil dominating protein calprotectin in feces: A methodologic study. Scand J Gastroenterol 1992;27:793-8.
26. Ton H, Brandsnes Ø, Dale S, et al. Improved assay for fecal calprotectin. Clin Chim Acta 2000;292:41-54.
27. Sykora J, Siala K, Huml M, et al. Evaluation of faecal calprotectin as a valuable non-invasive marker in distinguishing gut pathogens in young children with acute gastroenteritis. Acta Paediatr 2010;99:1389-95.
28. Shastri YM, Bergis D, Povse N, et al. Prospective multicenter study evaluating fecal calprotectin in adult acute bacterial diarrhea. Am J Med 2008;121:1099-106.
29. Schroder O, Naumann M, Shastri Y, et al. Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: Combination of parameters does not improve diagnostic accuracy of calprotectin. Aliment Pharmacol Ther 2007;26:1035-42.
30. Nissen AC, van Gils CE, Menheere PP, et al. Fecal calprotectin in healthy term and preterm infants. J Pediatr Gastroenterol Nutr 2004;38:107-8.
31. Kapel N, Campeotto F, Kalach N, et al. Fecal calprotectin in term and preterm neonates. J Pediatr Gastroenterol Nutr 2010;51:542-7.
32. Rugtveit J, Fagerhol MK. Age-dependent variations in fecal calprotectin concentrations in children. J Pediatr Gastroenterol Nutr 2002;34:323-5.