메뉴 건너뛰기




Volumn 19, Issue 11, 2012, Pages 1139-1146

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA; EXTRACELLULAR SUPEROXIDE DISMUTASE; HISTONE; HISTONE H2A; HISTONE MACROH2A1; RNA HELICASE; RNA HELICASE DDX17; RNA HELICASE DDX5; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84869097406     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2390     Document Type: Article
Times cited : (110)

References (59)
  • 2
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela, A. & Esteller, M. Epigenetic modifications and human disease. Nat. Biotechnol. 28, 1057-1068 (2010).
    • (2010) Nat. Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 3
    • 77149156308 scopus 로고    scopus 로고
    • The role of histone modifications and variants in regulating gene expression in breast cancer
    • Dalvai, M. & Bystricky, K. The role of histone modifications and variants in regulating gene expression in breast cancer. J. Mammary Gland Biol. Neoplasia 15, 19-33 (2010).
    • (2010) J. Mammary Gland Biol. Neoplasia , vol.15 , pp. 19-33
    • Dalvai, M.1    Bystricky, K.2
  • 4
    • 78650816688 scopus 로고    scopus 로고
    • The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
    • Kapoor, A. et al. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature 468, 1105-1109 (2010).
    • (2010) Nature , vol.468 , pp. 1105-1109
    • Kapoor, A.1
  • 5
    • 59349098153 scopus 로고    scopus 로고
    • Role of H2AX in DNA damage response and human cancers
    • Srivastava, N., Gochhait, S., de Boer, P. & Bamezai, R.N. Role of H2AX in DNA damage response and human cancers. Mutat. Res. 681, 180-188 (2009).
    • (2009) Mutat. Res , vol.681 , pp. 180-188
    • Srivastava, N.1    Gochhait, S.2    De Boer, P.3    Bamezai, R.N.4
  • 6
    • 84856518449 scopus 로고    scopus 로고
    • Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer
    • Valdés-Mora, F. et al. Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res. 22, 307-321 (2012).
    • (2012) Genome Res , vol.22 , pp. 307-321
    • Valdés-Mora, F.1
  • 7
    • 70349453738 scopus 로고    scopus 로고
    • Histone macroH2A isoforms predict the risk of lung cancer recurrence
    • Sporn, J.C. et al. Histone macroH2A isoforms predict the risk of lung cancer recurrence. Oncogene 28, 3423-3428 (2009).
    • (2009) Oncogene , vol.28 , pp. 3423-3428
    • Sporn, J.C.1
  • 8
    • 80555157615 scopus 로고    scopus 로고
    • QKI-mediated alternative splicing of the histone variant macroH2A1 regulates cancer cell proliferation
    • Novikov, L. et al. QKI-mediated alternative splicing of the histone variant macroH2A1 regulates cancer cell proliferation. Mol. Cell. Biol. 31, 4244-4255 (2011).
    • (2011) Mol. Cell. Biol , vol.31 , pp. 4244-4255
    • Novikov, L.1
  • 9
    • 67349097457 scopus 로고    scopus 로고
    • Cancer-associated regulation of alternative splicing
    • Venables, J.P. et al. Cancer-associated regulation of alternative splicing. Nat. Struct. Mol. Biol. 16, 670-676 (2009).
    • (2009) Nat. Struct. Mol. Biol , vol.16 , pp. 670-676
    • Venables, J.P.1
  • 10
    • 76249100558 scopus 로고    scopus 로고
    • Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasis
    • Dutertre, M. et al. Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasis. Cancer Res. 70, 896-905 (2010).
    • (2010) Cancer Res , vol.70 , pp. 896-905
    • Dutertre, M.1
  • 11
    • 78049416081 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing regulation in cancer: Pathways and programs unhinged
    • David, C.J. & Manley, J.L. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev. 24, 2343-2364 (2010).
    • (2010) Genes Dev , vol.24 , pp. 2343-2364
    • David, C.J.1    Manley, J.L.2
  • 12
    • 77957307409 scopus 로고    scopus 로고
    • Alternative splicing and breast cancer
    • Dutertre, M., Vagner, S. & Auboeuf, D. Alternative splicing and breast cancer. RNA Biol. 7, 403-411 (2010).
    • (2010) RNA Biol , vol.7 , pp. 403-411
    • Dutertre, M.1    Vagner, S.2    Auboeuf, D.3
  • 14
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan, Q., Shai, O., Lee, L.J., Frey, B.J. & Blencowe, B.J. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet. 40, 1413-1415 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 15
    • 79952105381 scopus 로고    scopus 로고
    • Understanding splicing regulation through RNA splicing maps
    • Witten, J.T. & Ule, J. Understanding splicing regulation through RNA splicing maps. Trends Genet. 27, 89-97 (2011).
    • (2011) Trends Genet , vol.27 , pp. 89-97
    • Witten, J.T.1    Ule, J.2
  • 16
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson, C.J. & Miller, F.R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 52, 1399-1405 (1992).
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 17
    • 77957772409 scopus 로고    scopus 로고
    • Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities
    • Bemmo, A. et al. Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities. PLoS ONE 5, e11981 (2010).
    • (2010) PLoS ONE , vol.5
    • Bemmo, A.1
  • 18
    • 79952148724 scopus 로고    scopus 로고
    • RNA helicases p68 and p72: Multifunctional proteins with important implications for cancer development
    • Fuller-Pace, F.V. & Moore, H.C. RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development. Future Oncol. 7, 239-251 (2011).
    • (2011) Future Oncol , vol.7 , pp. 239-251
    • Fuller-Pace, F.V.1    Moore, H.C.2
  • 19
    • 77954687609 scopus 로고    scopus 로고
    • Multi-talented DEAD-box proteins and potential tumor promoters: P68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17)
    • Janknecht, R. Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). Am. J. Transl. Res 2, 223-234 (2010).
    • (2010) Am. J. Transl. Res , vol.2 , pp. 223-234
    • Janknecht, R.1
  • 22
    • 0036318541 scopus 로고    scopus 로고
    • Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72
    • DOI 10.1128/MCB.22.16.5698-5707.2002
    • Hönig, A., Auboeuf, D., Parker, M.M., O'Malley, B.W. & Berget, S.M. Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. Mol. Cell Biol. 22, 5698-5707 (2002). (Pubitemid 34815820)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.16 , pp. 5698-5707
    • Honig, A.1    Auboeuf, D.2    Parker, M.M.3    O'Malley, B.W.4    Berget, S.M.5
  • 24
    • 79955379829 scopus 로고    scopus 로고
    • RNA Helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5′ splice site
    • Kar, A. et al. RNA Helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5′ splice site. Mol. Cell. Biol. 31, 1812-1821 (2011).
    • (2011) Mol. Cell. Biol , vol.31 , pp. 1812-1821
    • Kar, A.1
  • 26
    • 73549105474 scopus 로고    scopus 로고
    • The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing
    • Gamble, M.J., Frizzell, K.M., Yang, C., Krishnakumar, R. & Kraus, W.L. The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing. Genes Dev. 24, 21-32 (2010).
    • (2010) Genes Dev , vol.24 , pp. 21-32
    • Gamble, M.J.1    Frizzell, K.M.2    Yang, C.3    Krishnakumar, R.4    Kraus, W.L.5
  • 27
    • 70349804469 scopus 로고    scopus 로고
    • The histone variant macroH2A is an epigenetic regulator of key developmental genes
    • Buschbeck, M. et al. The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat. Struct. Mol. Biol. 16, 1074-1079 (2009).
    • (2009) Nat. Struct. Mol. Biol , vol.16 , pp. 1074-1079
    • Buschbeck, M.1
  • 28
    • 69949133036 scopus 로고    scopus 로고
    • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
    • Timinszky, G. et al. A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat. Struct. Mol. Biol. 16, 923-929 (2009).
    • (2009) Nat. Struct. Mol. Biol , vol.16 , pp. 923-929
    • Timinszky, G.1
  • 29
    • 77955452081 scopus 로고    scopus 로고
    • Multiple facets of the unique histone variant macroH2A: From genomics to cell biology
    • Gamble, M.J. & Kraus, W.L. Multiple facets of the unique histone variant macroH2A: from genomics to cell biology. Cell Cycle 9, 2568-2574 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 2568-2574
    • Gamble, M.J.1    Kraus, W.L.2
  • 30
    • 77955274524 scopus 로고    scopus 로고
    • Redox metabolism and malignancy
    • Grek, C.L. & Tew, K.D. Redox metabolism and malignancy. Curr. Opin. Pharmacol. 10, 362-368 (2010).
    • (2010) Curr. Opin. Pharmacol , vol.10 , pp. 362-368
    • Grek, C.L.1    Tew, K.D.2
  • 31
    • 77954562833 scopus 로고    scopus 로고
    • Metastasis cancer cell′s escape from oxidative stress
    • Pani, G., Galeotti, T. & Chiarugi, P. Metastasis: cancer cell′s escape from oxidative stress. Cancer Metastasis Rev. 29, 351-378 (2010).
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 351-378
    • Pani, G.1    Galeotti, T.2    Chiarugi, P.3
  • 32
    • 77954466425 scopus 로고    scopus 로고
    • Extracellular/microenvironmental redox state
    • Chaiswing, L. & Oberley, T.D. Extracellular/microenvironmental redox state. Antioxid. Redox Signal. 13, 449-465 (2010).
    • (2010) Antioxid. Redox Signal , vol.13 , pp. 449-465
    • Chaiswing, L.1    Oberley, T.D.2
  • 33
    • 5644272705 scopus 로고    scopus 로고
    • Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    • DOI 10.1158/0008-5472.CAN-04-1725
    • Mori, K., Shibanuma, M. & Nose, K. Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res. 64, 7464-7472 (2004). (Pubitemid 39372089)
    • (2004) Cancer Research , vol.64 , Issue.20 , pp. 7464-7472
    • Mori, K.1    Shibanuma, M.2    Nose, K.3
  • 34
    • 68049143319 scopus 로고    scopus 로고
    • Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion
    • Teoh, M.L., Fitzgerald, M.P., Oberley, L.W. & Domann, F.E. Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion. Cancer Res. 69, 6355-6363 (2009).
    • (2009) Cancer Res , vol.69 , pp. 6355-6363
    • Teoh, M.L.1    Fitzgerald, M.P.2    Oberley, L.W.3    Domann, F.E.4
  • 36
    • 77952974276 scopus 로고    scopus 로고
    • Helicases an overview
    • Abdelhaleem, M. Helicases: an overview. Methods Mol. Biol. 587, 1-12 (2010).
    • (2010) Methods Mol. Biol , vol.587 , pp. 1-12
    • Abdelhaleem, M.1
  • 37
    • 33749078750 scopus 로고    scopus 로고
    • P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from beta-Catenin
    • DOI 10.1016/j.cell.2006.08.036, PII S0092867406011585
    • Yang, L., Lin, C. & Liu, Z.R. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin. Cell 127, 139-155 (2006). (Pubitemid 44466634)
    • (2006) Cell , vol.127 , Issue.1 , pp. 139-155
    • Yang, L.1    Lin, C.2    Liu, Z.-R.3
  • 38
    • 84870460490 scopus 로고    scopus 로고
    • Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor
    • Germann, S. et al. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene 618, 1038-1048 (2012).
    • (2012) Oncogene , vol.618 , pp. 1038-1048
    • Germann, S.1
  • 39
    • 84863043265 scopus 로고    scopus 로고
    • RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells
    • Wang, D. et al. RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells. Mol. Cell Proteomics 11, M111.011932 (2012).
    • (2012) Mol. Cell Proteomics , vol.11 , Issue.M111 , pp. 011932
    • Wang, D.1
  • 40
    • 34548007885 scopus 로고    scopus 로고
    • Involvement of RNA helicases p68 and p72 in colon cancer
    • DOI 10.1158/0008-5472.CAN-06-4652
    • Shin, S., Rossow, K.L., Grande, J.P. & Janknecht, R. Involvement of RNA helicases p68 and p72 in colon cancer. Cancer Res. 67, 7572-7578 (2007). (Pubitemid 47281348)
    • (2007) Cancer Research , vol.67 , Issue.16 , pp. 7572-7578
    • Shin, S.1    Rossow, K.L.2    Grande, J.P.3    Janknecht, R.4
  • 41
    • 73449119972 scopus 로고    scopus 로고
    • Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential
    • Mooney, S.M., Grande, J.P., Salisbury, J.L. & Janknecht, R. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry 49, 1-10 (2010).
    • (2010) Biochemistry , vol.49 , pp. 1-10
    • Mooney, S.M.1    Grande, J.P.2    Salisbury, J.L.3    Janknecht, R.4
  • 42
    • 70450199132 scopus 로고    scopus 로고
    • The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer
    • Wortham, N.C. et al. The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer. Oncogene 28, 4053-4064 (2009).
    • (2009) Oncogene , vol.28 , pp. 4053-4064
    • Wortham, N.C.1
  • 43
    • 21344459251 scopus 로고    scopus 로고
    • Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation
    • DOI 10.1158/1541-7786.MCR-05-0022
    • Yang, L., Lin, C. & Liu, Z.R. Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation. Mol. Cancer Res. 3, 355-363 (2005). (Pubitemid 40905627)
    • (2005) Molecular Cancer Research , vol.3 , Issue.6 , pp. 355-363
    • Yang, L.1    Lin, C.2    Liu, Z.-R.3
  • 44
    • 77957605910 scopus 로고    scopus 로고
    • Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter
    • Carter, C.L., Lin, C., Liu, C.Y., Yang, L. & Liu, Z.R. Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter. Oncogene 29, 5427-5436 (2010).
    • (2010) Oncogene , vol.29 , pp. 5427-5436
    • Carter, C.L.1    Lin, C.2    Liu, C.Y.3    Yang, L.4    Liu, Z.R.5
  • 46
    • 34548252476 scopus 로고    scopus 로고
    • SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1
    • Jacobs, A.M. et al. SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. Oncogene 26, 5866-5876 (2007).
    • (2007) Oncogene , vol.26 , pp. 5866-5876
    • Jacobs, A.M.1
  • 47
    • 77957287427 scopus 로고    scopus 로고
    • Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase
    • Mooney, S.M., Goel, A., Dassoro, A.B., Salisbury, J.L. & Janknecht, R. Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J. Biol. Chem. 285, 30443-30452 (2010).
    • (2010) J. Biol. Chem , vol.285 , pp. 30443-30452
    • Mooney, S.M.1    Goel, A.2    Dassoro, A.B.3    Salisbury, J.L.4    Janknecht, R.5
  • 48
    • 84861614453 scopus 로고    scopus 로고
    • Differential regulation and predictive potential of MacroH2A1 isoforms in colon cancer
    • Sporn, J.C. & Jung, B. Differential regulation and predictive potential of MacroH2A1 isoforms in colon cancer. Am. J. Pathol. 180, 2516-2526 (2012).
    • (2012) Am. J. Pathol , vol.180 , pp. 2516-2526
    • Sporn, J.C.1    Jung, B.2
  • 50
    • 77954274504 scopus 로고    scopus 로고
    • The PARP side of the nucleus: Molecular actions, physiological outcomes, and clinical targets
    • Krishnakumar, R. & Kraus, W.L. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol. Cell 39, 8-24 (2010).
    • (2010) Mol. Cell , vol.39 , pp. 8-24
    • Krishnakumar, R.1    Kraus, W.L.2
  • 51
  • 52
    • 79959521749 scopus 로고    scopus 로고
    • The redox basis of epigenetic modifications: From mechanisms to functional consequences
    • Cyr, A.R. & Domann, F.E. The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid. Redox Signal. 15, 551-589 (2011).
    • (2011) Antioxid. Redox Signal , vol.15 , pp. 551-589
    • Cyr, A.R.1    Domann, F.E.2
  • 53
    • 77953384917 scopus 로고    scopus 로고
    • Redox regulation in cancer: A double-edged sword with therapeutic potential
    • Acharya, A., Das, I., Chandhok, D. & Saha, T. Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxid. Med. Cell. Longev. 3, 23-34 (2010).
    • (2010) Oxid. Med. Cell. Longev , vol.3 , pp. 23-34
    • Acharya, A.1    Das, I.2    Chandhok, D.3    Saha, T.4
  • 54
    • 73949147048 scopus 로고    scopus 로고
    • Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins
    • Weaver, A.M. Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins. Sci. Signal. 2, pe56 (2009).
    • (2009) Sci. Signal , vol.2
    • Weaver, A.M.1
  • 55
    • 48549089006 scopus 로고    scopus 로고
    • The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function
    • Svineng, G., Ravuri, C., Rikardsen, O., Huseby, N.E. & Winberg, J.O. The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function. Connect. Tissue Res. 49, 197-202 (2008).
    • (2008) Connect. Tissue Res , vol.49 , pp. 197-202
    • Svineng, G.1    Ravuri, C.2    Rikardsen, O.3    Huseby, N.E.4    Winberg, J.O.5
  • 57
    • 84863307537 scopus 로고    scopus 로고
    • The atypical histone macroH2A1.2 interacts with HER-2 in cancer cells
    • Li, X. et al. The atypical histone macroH2A1.2 interacts with HER-2 in cancer cells. J. Biol. Chem. 287, 23171-23183 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 23171-23183
    • Li, X.1
  • 59
    • 51349121081 scopus 로고    scopus 로고
    • Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes
    • Bittencourt, D. et al. Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes. Mol. Cell. Biol. 28, 5811-5824 (2008).
    • (2008) Mol. Cell. Biol , vol.28 , pp. 5811-5824
    • Bittencourt, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.