A biochemical rationale for the interaction between gastrointestinal yeast and autism

Medical Hypotheses

Volumn 79, Issue 6, 2012, Pages 784-785

  Burrus, Caley J ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; AMMONIA; BETA ALANINE; FLUCONAZOLE; GLUCOSE; NYSTATIN; PROPIONIC ACID; SUGAR;

ARTICLE; AUTISM; BLOOD BRAIN BARRIER; BRAIN; CANDIDA ALBICANS; CHILD; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DISEASE COURSE; FUNGUS; GASTROINTESTINAL TRACT; GLUCOSE INTOLERANCE; GLUTEN FREE DIET; HUMAN; NEUROTRANSMISSION; NONHUMAN; QUALITATIVE RESEARCH; SCREENING TEST; SUGAR INTAKE; YEAST;

AUTISTIC DISORDER; CANDIDA ALBICANS; GASTROINTESTINAL TRACT; HUMANS; MODELS, THEORETICAL;

CANDIDA ALBICANS;

EID: 84869092281     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.08.029     Document Type: Article

References (10)

1. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association, 2000.
2. Centers for Disease Control. CDC Estimates 1 in 88 children in the United States has been identified as having an autism spectrum disorder. 29 Mar 2012. 17 May 2012. http://www.cdc.gov/media/releases/2012/p0329_autism_disorder.html.
3. Shultz S., MacFabe D., Ossenkopp K., et al. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology 2008, 54:901-911.
4. Reichelt K., Knivsberg A. The possibility and probability of a gut-to-brain connection in autism. Am Clin Psychiatry 2009, 21:205-211.
5. Aldred S., Moore K., Fitzgerald M., Waring R. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord 2003, 33:93-97.
6. Ishiwari K., Mingote S., Correa M., Trevitt J., Carlson B., Salamone J. The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extraceullular GABA in substantia nigra pars reticulata as measured by microdialysis. J Neurosci Methods 2004, 140:39-46.
7. Komura J., Tamai I., Senmaru M., Terasaki T., Sai Y., Tsuji A. Brain-to-blood active transport of beta-alanine across the blood-brain barrier. FEBS Lett 1997, 400:131-135.
8. McCormick D. GABA as an inhibitory neurotransmitterin human cerebral cortex. J Neurophysiol 1989, 62:1018-1027.
9. Williams B., et al. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PloS ONE 2011, 6:1-21.
10. Whiteley P., Rodgers J., Savery D., Shattock P. A Gluten-free diet as an intervention for autism and associated spectrum disorders: preliminary findings. Autism 1999, 3:45-65.