Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 23, 2012, Pages 6811-6820

  Li, Bingbing X ^a   Yamanaka, Kinrin ^a   Xiao, Xiangshu ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cancer; CBP; CREB; Inhibitor; Naphthol AS E; Transcription

Indexed keywords

2,2 DIMETHYL 4H NAPHTHO[2,3 D][1,3]DIOXIN 4 ONE; 3 HYDROXY N (4 HYDROXYPHENYL) 2 NAPHTHAMIDE; 3 HYDROXY N (4 IODOPHENYL) 2 NAPHTHAMIDE; 3 HYDROXY N (4 METHOXYPHENYL) 2 NAPHTHAMIDE; 3 HYDROXY N (4 TRIFLUOROMETHYLPHENYL) 2 NAPHTHAMIDE; 3 HYDROXY N (PYRAZIN 2 YL) 2 NAPHTHAMIDE; 3 HYDROXY N (PYRIDIN 2 YL) 2 NAPHTHAMIDE; 3 HYDROXY N (PYRIDIN 4 YL) 2 NAPHTHAMIDE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOTOXIC AGENT; N (2 CHLOROPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; N (3 CHLOROPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; N (3,4 DIFLUOROPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; N (4 AMINOPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; N (4 BROMOPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; N (4 FLUOROPHENYL) 3 HYDROXY 2 NAPHTHAMIDE; NAPHTHOL AS E; PROTEIN KID; PROTEIN KIX; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; DOWN REGULATION; DRUG DESIGN; DRUG SCREENING; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUTATION; NAPHTHOLS; NEOPLASMS; PROTEIN INTERACTION MAPPING; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 84869086946     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.056     Document Type: Article

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