ESI-MSn and LC-ESI-MS studies to characterize forced degradation products of bosentan and a validated stability-indicating LC-UV method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 72, Issue , 2013, Pages 186-197

  Bansal, Gulshan ^a   Singh, Ranjit ^a   Saini, Balraj ^a   Bansal, Yogita ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Bosentan; Forced degradation; Mass fragmentation; Stability indicating; Validation

Indexed keywords

2 [2 (2 HYDROXYETHOXY)PHENOXY]ETHANOL; 2 [6 AMINO 5 (2 METHOXYPHENOXY)[2,2']BIPYRIMIDINYL 4 YLOXY]ETHANOL; 4 TERT BUTYL N [6 (1 METHOXYETHOXY) 5 (2 METHOXYPHENOXY) N [2,2']BIPYRIMIDINYL 4 YL]BENZENESULFONAMIDE; 6 AMINO 5 (2 METHOXYPHENOXY)[2,2']BIPYRIMIDINYL 4 OL; 6 AMINO[2,2']BIPYRIMIDINYL 4,5 DIOL; BETA HYDROXYETHYL 4 TERT BUTYLPHENYLSULFONATE; BOSENTAN; UNCLASSIFIED DRUG; WATER; ETHER; SULFONAMIDE;

ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; DRUG DEGRADATION; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; HEAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; OXIDATION; PHOTOLYSIS; PRIORITY JOURNAL; TABLET; VALIDATION PROCESS; CHEMISTRY; DEHYDRATION; MASS SPECTROMETRY; METHODOLOGY; OXIDATION REDUCTION REACTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEHYDRATION; DRUG STABILITY; ETHER, ETHYL; HOT TEMPERATURE; HYDROLYSIS; MASS SPECTROMETRY; OXIDATION-REDUCTION; PHOTOLYSIS; SULFONAMIDES; TABLETS;

EID: 84869086841     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.08.014     Document Type: Article

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