Cerebrospinal fluid neuropeptide Y-like immunoreactivity correlates with impulsive aggression in human subjects

Biological Psychiatry

Volumn 72, Issue 12, 2012, Pages 997-1003

  Coccaro, Emil F ^a   Lee, Royce ^a   Liu, Tianmin ^b   Mathé, Aleksander A ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Aggression; CSF; impulsivity; NPY LI; personality; suicidal behavior

Indexed keywords

NEUROPEPTIDE Y; NEUROTRANSMITTER;

ADULT; AGGRESSION; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOREACTIVITY; IMPULSIVENESS; INTERMITTENT EXPLOSIVE DISORDER; MALE; NEUROMODULATION; PERSONALITY DISORDER; PRIORITY JOURNAL;

ADULT; AGGRESSION; DATA INTERPRETATION, STATISTICAL; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; MALE; NEUROPEPTIDE Y; PERSONALITY DISORDERS; PERSONALITY TESTS; SPINAL PUNCTURE; SUICIDE, ATTEMPTED;

EID: 84869078859     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.07.029     Document Type: Article

References (71)

1. J.P. Redrobe, Y. Dumont, R. Quirion Neuropeptide Y (NPY) and depression: From animal studies to the human condition Life Sci 71 2002 2921 2937
2. L. Sosulina, G. Schwesig, G. Seifert, H.C. Pape Neuropeptide Y activates a G-protein-coupled inwardly rectifying potassium current and dampens excitability in the lateral amygdala Mol Cell Neurosci 39 2008 491 498
3. L.Y. Fu, C. Acuna-Goycolea, A.N. van den Pol Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: Tonic depression of the hypothalamic arousal system J Neurosci 24 2004 8741 8751
4. L. Yang, K.A. Scott, J. Hyun, K.L. Tamashiro, N. Tray, T.H. Moran, S. Bi Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance J Neurosci 29 2009 179 190
5. N. Sato, Y. Ogino, S. Mashiko, M. Ando Modulation of neuropeptide Y receptors for the treatment of obesity Expert Opin Ther Pat 19 2009 1401 1415
6. H. Himmerich, P. Schönknecht, S. Heitmann, A.J. Sheldrick Laboratory parameters and appetite regulators in patients with anorexia nervosa J Psychiatr Pract 16 2010 82 92
7. S. Bi Role of dorsomedial hypothalamic neuropeptide Y in energy homeostasis Peptides 28 2007 352 356
8. B. Solway, S.C. Bose, G. Corder, R.R. Donahue, B.K. Taylor Tonic inhibition of chronic pain by neuropeptide Y Proc Natl Acad Sci U S A 108 2011 7224 7229
9. L.C. Roeske, A.P. Auchus Neuropeptide changes in cortical and deep gray structures in Alzheimers disease Rev Neurosci 6 1995 317 328
10. J. Kuromitsu, A. Yokoi, T. Kawai, T. Nagasu, T. Aizawa, S. Haga, K. Ikeda Reduced neuropeptide Y mRNA levels in the frontal cortex of people with schizophrenia and bipolar disorder Brain Res Gene Expr Patterns 1 2001 17 21
11. M. Heilig, O. Zachrisson, A. Thorsell, A. Ehnvall, S. Mottagui-Tabar, M. Sjogren et al. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: Preliminary evidence for association with preproNPY gene polymorphism J Psychiatr Res 38 2004 113 121
12. M. Heilig The NPY system in stress, anxiety and depression Neuropeptides 38 2004 213 224
13. J. Peters, D.P. Van Kammen, J. Gelernter, J. Yao, D. Shaw Neuropeptide Y-like immunoreactivity in schizophrenia. Relationships with clinical measures Schizophr Res 3 1990 287 294
14. T.R. Gregg, A. Siegel Brain structures and neurotransmitters regulating aggression in cats: Implications for human aggression Prog Neuropsychopharmacol Biol Psychiatry 25 2001 91 140
15. T. Kishi, C.J. Aschkenasi, B.J. Choi, M.E. Lopez, C.E. Lee, H. Liu et al. Neuropeptide Y Y1 receptor mRNA in rodent brain: Distribution and colocalization with melanocortin-4 receptor J Comp Neurol 482 2005 217 243
16. R.B. Emeson, M.V. Morabito Food fight: The NPY-serotonin link between aggression and feeding behavior Sci STKE 2005 2005 pe12
17. N.J. Rutkoski, A.A. Lerant, C.M. Nolte, J. Westberry, C.W. Levenson Regulation of neuropeptide Y in the rat amygdale following unilateral olfactory bulbectomy Brain Res 951 2002 69 76
18. A. Kask, J. Harro Inhibition of amphetamine- and apomorphine-induced behavioral effects by neuropeptide Y Y(1) receptor antagonist BIBO 3304 Neuropharmacology 39 2000 1292 1302
19. T. Karl, S. Lin, C. Schwarzer, A. Sainsbury, M. Couzens, W. Wittmann et al. Y1 receptors regulate aggressive behavior by modulating serotonin pathways Proc Natl Acad Sci U S A 101 2004 12742 12747
20. B. Greco, M. Carli Reduced attention and increased impulsivity in mice lacking NPY Y2 receptors: Relation to anxiolytic-like phenotype Behav Brain Res 169 2006 325 334
21. A. Sainsbury, C. Schwarzer, M. Couzens, A. Jenkins, S.R. Oakes, C.J. Ormandy, H. Herzog Y4 receptor knockout rescues fertility in ob/ob mice Genes Dev 16 2002 1077 1088
22. American Psychiatric Association Diagnostic and Statistical Manual, 4th ed (DSM-IV) 1994 American Psychiatric Press Washington, DC
23. E.F. Coccaro Intermittent explosive disorder: Development of integrated research criteria for diagnostic and statistical manual-fifth edition Compr Psychiatry 52 2011 119 125
24. M.B. First, R. Spitzer, M. Gibbon, J.B.W. Williams Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) 1997 Psychiatric Institute, Biometrics Research New York
25. B. Pfohl, N. Blum, M. Zimmerman Structured Interview for DSM-IV Personality: SIDP-IV 1997 American Psychiatric Press Washington, DC
26. J.F. Leckman, D. Sholomskas, W.D. Thompson, A. Belanger, M.M. Weissman Best estimate of lifetime psychiatric diagnosis: A methodological study Arch Gen Psychiatry 39 1982 879 883
27. D.N. Klein, P.C. Ouimette, H.S. Kelly, T. Ferro, L.P. Riso Test-retest reliability of team consensus best-estimate diagnoses of axis I and II disorders in a family study Am J Psychiatry 151 1994 1043 1047
28. T.A. Kosten, B.J. Rounsaville Sensitivity of psychiatric diagnosis based on the best estimate procedure Am J Psychiatry 149 1992 1225 1227
29. E.F. Coccaro, M.E. Berman, R.J. Kavoussi Assessment of life history of aggression: Development and psychometric characteristics Psychiatry Res 73 1997 147 157
30. A.H. Buss, A. Durkee An inventory for assessing different kinds of hostility J Consult Psychol 21 1957 343 348
31. S.B.G. Eysenck, H.J. Eysenck The place of impulsiveness in a dimensional system of personality description Br J Soc Clin Psychol 16 1977 57 68
32. J.H. Patton, M.S. Stanford, E.S. Barratt Factor structure of the Barratt Impulsiveness Scale J Clin Psychol 51 1995 768 774
33. E.F. Coccaro, L.J. Siever, H.M. Klar, G. Maurer, K. Cochrane, R.C. Mohs, K.L. Davis Serotonergic studies in affective and personality disorder: Correlates with suicidal and impulsive aggressive behavior Arch Gen Psychiatry 46 1989 587 599
34. H.J. Eysenck, S.B.G. Eysenck Manual of the Eysenck Personality Questionnaire 1975 Hodder and Stoughton London
35. C. Stenfors, E. Theodorsson, A.A. Mathe Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain J Neurosci Res 24 1989 445 450
36. E.F. Coccaro, R. Lee Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: Reciprocal relationships with impulsive aggression in human subjects J Neural Transm 117 2010 241 248
37. E.F. Coccaro, R.K. Kavoussi, R.L. Hauger, T.B. Cooper, C.F. Ferris Cerebrospinal fluid vasopressin: Correlates with aggression and serotonin function in personality disordered subjects Arch Gen Psychiatry 55 1998 708 714
38. R. Lee, C. Ferris, L.D. Van de Kar, E.F. Coccaro Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder Psychoneuroendocrinology 34 2009 1567 1573
39. E.F. Coccaro, R. Lee, R.J. Kavoussi Aggression, suicidality, and intermittent explosive disorder: Serotonergic correlates in personality disorder and healthy control subjects Neuropsychopharmacology 35 2010 435 444
40. A. Roy Neuropeptides in relation to suicidal behavior in depression Neuropsychobiology 28 1993 184 186
41. W.H. Kaye, W. Berrettini, H. Gwirtsman, D.T. George Altered cerebrospinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa Arch Gen Psychiatry 47 1990 548 556
42. R.F. Valenzuela, M.V. Donoso, P.A. Mellado, J.P. Huidobro-Toro Migraine, but not subarachnoid hemorrhage, is associated with differentially increased NPY-like immunoreactivity in the CSF J Neurol Sci 173 2000 140 146
43. Z. Stachura, E. Obuchowicz, Z.S. Herman Neuropeptide Y-like immunoreactivity in lumbar cerebrospinal fluid of patients after severe head trauma Neuropeptides 31 1997 12 14
44. A. Akefeldt, R. Ekman, J.E. Månsson Cerebrospinal fluid neuropeptide Y in Prader-Willi syndrome Dev Med Child Neurol 43 2001 286 287
45. M. Cao, S. Zhang, K. Wang, Y. Wang, W. Wang Personality traits in migraine and tension-type headaches: A five-factor model study Psychopathology 35 2002 254 258
46. A. Harrison, R. Genders, H. Davies, J. Treasure, K. Tchanturia Experimental measurement of the regulation of anger and aggression in women with anorexia nervosa Clin Psychol Psychother 18 2011 445 452
47. K.A. Nolan, D. DAngelo, M.J. Hoptman Self-report and laboratory measures of impulsivity in patients with schizophrenia or schizoaffective disorder and healthy controls Psychiatry Res 187 2011 301 303
48. V. Rao, P. Rosenberg, M. Bertrand, S. Salehinia, J. Spiro, S. Vaishnavi et al. Aggression after traumatic brain injury: Prevalence and correlates J Neuropsychiatry Clin Neurosci 21 2009 420 429
49. D.J. Stein, J. Keating, H.J. Zar, E. Hollander A survey of the phenomenology and pharmacotherapy of compulsive and impulsive-aggressive symptoms in Prader-Willi syndrome J Neuropsychiatry Clin Neurosci 6 1994 23 29
50. G. Nikisch, H. Agren, C.B. Eap, A. Czernik, P. Baumann, A.A. Mathé Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram Int J Neuropsychopharmacol 8 2005 403 410
51. C. Hou, F. Jia, Y. Liu, L. Li CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder Brain Res 1095 2006 154 158
52. A. Gjerris, E. Widerlöv, L. Werdelin, R. Ekman Cerebrospinal fluid concentrations of neuropeptide Y in depressed patients and in controls J Psychiatry Neurosci 17 1992 23 27
53. C.L. Nilsson, A. Brinkmalm, L. Minthon, K. Blennow, R. Ekman Processing of neuropeptide Y, galanin, and somatostatin in the cerebrospinal fluid of patients with Alzheimers disease and frontotemporal dementia Peptides 22 2001 2105 2112
54. L. Edvinsson, L. Minthon, R. Ekman, L. Gustafson Neuropeptides in cerebrospinal fluid of patients with Alzheimers disease and dementia with frontotemporal lobe degeneration Dementia 4 1993 167 171
55. E. Martignoni, F. Blandini, F. Petraglia, C. Pacchetti, G. Bono, G. Nappi Cerebrospinal fluid norepinephrine, 3-methoxy-4-hydroxyphenylglycol and neuropeptide Y levels in Parkinsons disease, multiple system atrophy and dementia of the Alzheimer type J Neural Transm Park Dis Dement Sect 4 1992 191 205
56. J. Alom, R. Galard, R. Catalan, J.M. Castellanos, S. Schwartz, E. Tolosa Cerebrospinal fluid neuropeptide Y in Alzheimers disease Eur Neurol 30 1990 207 2100
57. M. Altemus, K.R. Jacobson, M. Debellis, M. Kling, T. Pigott, D.L. Murphy, P.W. Gold Normal CSF oxytocin and NPY levels in OCD Biol Psychiatry 45 1999 931 933
58. A. Roy, W. Berrettini, J. DeJong, B. Adinoff, B. Ravitz, M. Linnoila CSF neuropeptide Y in alcoholics and normal controls Psychiatry Res 33 1990 215 219
59. L. Vécsei, B. Csala, E. Widerlöv, R. Ekman, J. Czopf, G. Pàlffy Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis Brain Res Bull 25 1990 411 413
60. A. Brunani, C. Invitti, A. Dubini, R. Piccoletti, P. Bendinelli, P. Maroni et al. Cerebrospinal fluid and plasma concentrations of SRIH, beta-endorphin, CRH, NPY and GHRH in obese and normal weight subjects Int J Obes Relat Metab Disord 19 1995 17 21
61. Y.S. Allen, T.E. Adrian, J.M. Allen, K. Tatemoto, T.J. Crow, S.R. Bloom, J.M. Polak Neuropeptide Y distribution in the rat brain Science 221 1983 877 879
62. T.S. Gray, J.E. Morley Neuropeptide Y: Anatomical distribution and possible function in mammalian nervous system Life Sci 38 1986 389 401
63. T.L. ODonohue, B.M. Chronwall, R.M. Pruss, E. Mezey, J.Z. Kiss, L.E. Eiden et al. Neuropeptide Y and peptide YY neuronal and endocrine systems Peptides 6 1985 755 768
64. W.H. Berrettini, G. Oxenstierna, G. Sedvall, J.I. Nurnberger Jr, P.W. Gold, D.R. Rubinow, L.R. Goldin Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research Psychiatry Res 25 1988 349 359
65. S.Y. Nam, J. Kratzsch, K.W. Kim, K.R. Kim, S.K. Lim, C. Marcus Cerebrospinal fluid and plasma concentrations of leptin, NPY, and alpha-MSH in obese women and their relationship to negative energy balance J Clin Endocrinol Metab 86 2001 4849 4853
66. A.J. Kastin, V. Akerstrom Nonsaturable entry of neuropeptide Y into brain Am J Physiol 276 1999 E479 E482
67. L. Ste Marie, S. Luquet, T.B. Cole, R.D. Palmiter Modulation of neuropeptide Y expression in adult mice does not affect feeding Proc Natl Acad Sci U S A 102 2005 18632 18637
68. P. Walker, E. Grouzmann, M. Burnier, B. Waeber The role of neuropeptide Y in cardiovascular regulation Trends Pharmacol Sci 12 1991 111 115
69. J. Dötsch, M. Adelmann, P. Englaro, A. Dötsch, J. Hänze, W.F. Blum et al. Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid J Neurol Sci 151 1997 185 188
70. R.C. Kessler, E.F. Coccaro, M. Fava, S. Jaeger, R. Jin, E. Walters The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication Arch Gen Psychiatry 63 2006 669 678
71. E.F. Coccaro, R.J. Lee, R.J. Kavoussi A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder J Clin Psychiatry 70 2009 653 662