Pseudotyped Adeno-Associated Virus 2/9-Delivered CCL11 shRNA Alleviates Lung Inflammation in an Allergen-Sensitized Mouse Model

Human Gene Therapy

Volumn 23, Issue 11, 2012, Pages 1156-1165

  Wu, Chia Jen ^a   Huang, Wen Chung ^b   Chen, Li Chen ^c   Shen, Chia Rui ^a   Kuo, Ming Ling ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; EOTAXIN; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; RECOMBINANT ALLERGEN; SHORT HAIRPIN RNA;

AIRWAY RESISTANCE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CHEMOSENSITIZATION; CONTROLLED STUDY; DERMATOPHAGOIDES PTERONYSSINUS; DRUG DELIVERY SYSTEM; DRUG EFFICACY; EOSINOPHILIA; FEMALE; GENE TRANSFER; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; LYMPHOCYTE; MOUSE; NONHUMAN; PNEUMONIA; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN TARGETING; REPORTER GENE; RESPIRATORY TRACT ALLERGY; SPLEEN CELL; SUPERNATANT; TH2 CELL; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

AIRWAY REMODELING; AIRWAY RESISTANCE; ALLERGENS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL11; DEPENDOVIRUS; EOSINOPHILS; FEMALE; GENE ORDER; GENETIC VECTORS; HUMANS; MICE; NIH 3T3 CELLS; PNEUMONIA; RESPIRATORY HYPERSENSITIVITY; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC;

ACARI; ADENO-ASSOCIATED VIRUS; DERMATOPHAGOIDES PTERONYSSINUS; MUS;

EID: 84869058031     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2012.012     Document Type: Article

References (57)

1. Alexander, I.E., Russell, D.W., Spence, A.M., et al. (1996). Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adenoassociated virus vectors. Hum. Gene Ther. 7, 841-850.
2. Auricchio, A., O'Connor, E., Weiner, D., et al. (2002). Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins. J. Clin. Invest. 110, 499-504.
3. Barnett, B.G., Crews, C.J., Douglas, J.T. (2002). Targeted adenoviral vectors. Biochim. Biophys. Acta. 1575, 1-14.
4. Bell, C.L., Vandenberghe, L.H., Bell, P., et al. (2011). The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice. J. Clin. Invest. 121, 2427-2435.
5. Campbell, E.M., Kunkel, S.L., Strieter, R.M., et al. (1998). Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J. Immunol. 161, 7047-7053.
6. Chen, C.C., Sun, C.P., Ma, H.I., et al. (2009). Comparative study of anti-hepatitis B virus RNA interference by double-stranded adeno-associated virus serotypes 7, 8, and 9. Mol. Ther. 17, 352-359.
7. Chiba, Y., Kurotani, R., Kusakabe, T., et al. (2006). Uteroglobinrelated protein 1 expression suppresses allergic airway inflammation in mice. Am. J. Respir. Crit. Care Med. 173, 958-964.
8. Daya, S., and Berns, K.I. (2008). Gene therapy using adenoassociated virus vectors. Clin. Microbiol. Rev. 21, 583-593.
9. Di Pasquale, G., and Chiorini, J.A. (2006). AAV transcytosis through barrier epithelia and endothelium. Mol. Ther. 13, 506-516.
10. Douglas, J.T. (2007). Adenoviral vectors for gene therapy. Mol. Biotechnol. 36, 71-80.
11. Dykxhoorn, D.M., and Lieberman, J. (2006). Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu. Rev. Biomed. Eng. 8, 377-402.
12. Fujisawa, T., Kato, Y., Nagase, H., et al. (2000). Chemokines induce eosinophil degranulation through CCR-3. J. Allergy Clin. Immunol. 106, 507-513.
13. Gao, G., Vandenberghe, L.H., Alvira, M.R., et al. (2004). Clades of adeno-associated viruses are widely disseminated in human tissues. J. Virol. 78, 6381-6388.
14. Gauvreau, G.M., Boulet, L.P., Cockcroft, D.W., et al. (2008). Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses. Am. J. Respir. Crit. Care Med. 177, 952-958.
15. Goncalves, M.A. (2005). Adeno-associated virus: from defective virus to effective vector. Virol. J. 2, 43.
16. Gonzalez, R., Yang, Y.H., Griffin, C., et al. (2005). Freshly isolated rat alveolar type I cells, type II cells, and cultured type II cells have distinct molecular phenotypes. Am. J. Physiol. Lung Cell Mol. Physiol. 288, L179-189.
17. Gonzalo, J.A., Jia, G.Q., Aguirre, V., et al. (1996). Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Immunity 4, 1-14.
18. Gonzalo, J.A., Lloyd, C.M., Wen, D., et al. (1998). The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J. Exp. Med. 188, 157-167.
19. Halbert, C.L., Rutledge, E.A., Allen, J.M., et al. (2000). Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J. Virol. 74, 1524-1532.
20. Halbert, C.L., Allen, J.M., and Miller, A.D. (2001). Adenoassociated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors. J. Virol. 75, 6615-6624.
21. Hassani, Z., Francois, J.C., Alfama, G., et al. (2007). A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain. Nucleic Acids Res. 35, e65.
22. Heilbronn, R., Weger, S. (2010). Viral vectors for gene transfer: current status of gene therapeutics. Handb. Exp. Pharmacol., 143-170.
23. Hsu, C.Y., Leu, S.J., Chiang, B.L., et al. (2010). Cytokine genemodulated dendritic cells protect against allergic airway inflammation by inducing IL-10(+)IFN-gamma(+)CD4(+) T cells. Gene Ther. 17, 1011-1021.
24. Huang, H.Y., Lee, C.C., and Chiang, B.L. (2008). Small interfering RNA against interleukin5 decreases airway eosinophilia and hyper-responsiveness. Gene Ther. 15, 660-667.
25. Huang, H.Y., Lee, C.C., and Chiang. B.L. (2009). Short hairpin RNAs against eotaxin or interleukin-5 decrease airway eosinophilia and hyper-responsiveness in a murine model of asthma. J. Gene Med. 11, 112-118.
26. Joachim, R.A., Sagach, V., Quarcoo, D., et al. (2007). Effect of stress on eotaxin and expression of adhesion molecules in a murine model of allergic airway inflammation. J. Neuroimmunol. 182, 55-62.
27. Kay, A.B., and Klion, A.D. (2004). Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome. Immunol. Allergy Clin. North Am. 24, 645-666, vii.
28. Leigh, M.W., Kylander, J.E., Yankaskas, J.R., et al. (1995). Cell proliferation inbronchial epithelium and submucosal glands of cystic fibrosis patients. Am. J. Respir. Cell Mol. Biol. 12, 605-612.
29. Li, G., Liu, Z., Zhong, N., et al. (2006). Therapeutic effects of DNA vaccine on allergen-induced allergic airway inflammation in mouse model. Cell Mol. Immunol. 3, 379-384.
30. Limberis, M.P., and Wilson, J.M. (2006). Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered. Proc. Natl. Acad. Sci. U S A 103, 12993-12998.
31. Limberis, M.P., Vandenberghe, L.H., Zhang, L., et al. (2009). Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro. Mol. Ther. 17, 294-301.
32. Lin, C.K., Hung, M.S., Fang, C.P., et al. (2006). Survey of asthmatic patients' sensitization to house dust mites in southwestern Taiwan. Chang Gung Med. J. 29, 568-575.
33. Mao, H., Wen, F.Q., Liu, C.T., et al. (2006). Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing vector on bone marrow eosinophilopoiesis in asthmatic mice. Adv. Ther. 23, 938-956.
34. Mori, S., Wang, L., Takeuchi, T., et al. (2004). Two novel adenoassociated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein. Virology 330, 375-383.
35. Moschos, S.A., Frick, M., Taylor, B., et al. (2011). Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. Mol. Ther. 19, 2163-2168.
36. Mueller, C., Braag, S.A., Martino, A.T., et al. (2009). The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/-dependent allergy mouse model. Gene Ther. 16, 172-183.
37. Ou-Yang, H.F., Hu, X.B., Ti, X.Y., et al. (2009). Suppression of allergic airway inflammation in a mouse model by Der p2 recombined BCG. Immunology 128, e343-352.
38. Rabinowitz, J.E., Rolling, F., Li, C., et al. (2002). Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J. Virol. 76, 791-801.
39. Rothenberg, M.E. (1998). Eosinophilia. N. Engl. J. Med. 338, 1592-1600.
40. Rothenberg, M.E., Maclean, J.A., Pearlman, E., et al. (1997). Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J. Exp. Med. 185, 785-790.
41. Rutledge, E.A., Halbert, C.L., and Russell, D.W. (1998). Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. J. Virol. 72, 309-319.
42. Song, S., Embury, J., Laipis, P.J., et al. (2001). Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Ther. 8, 1299-1306.
43. Su, J., Zhu, Z., Xiong, F., et al. (2008). Hybrid cytomegalovirus-U6 promoter-based plasmid vectors improve efficiency of RNA interference in zebrafish. Mar. Biotechnol. 10, 511-517.
44. Sun, L., Guo, R.F., Gao, H., et al. (2009). Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells. Faseb J. 23, 3808-3818.
45. Tomkinson, A., Duez, C., Cieslewicz, G., et al. (2001). Eotaxin-1-deficient mice develop airway eosinophilia and airway hyperresponsiveness. Int. Arch. Allergy Immunol. 126, 119-125.
46. Tsai, J.J., Shen, H.D., and Chua, K.Y. (2000). Purification of group 2 Dermatophagoides pteronyssinus allergen and prevalence of its specific IgE in asthmatics. Int. Arch. Allergy Immunol. 121, 205-210.
47. Tsai, J.J., Liu, Y.H., Shen, H.D., et al. (2002). Prevention of Der p2-induced allergic airway inflammation by Mycobacteriumbacillus Calmette Guerin. J. Microbiol. Immunol. Infect. 35, 152-158.
48. Wang, C.C., Fu, C.L., Yang, Y.H., et al. (2006). Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther. 13, 1414-1421.
49. Wang, S.Y., Yang, M., Xu, X.P., et al. (2008). Intranasal delivery of T-bet modulates the profile of helper T cell immune responses in experimental asthma. J. Investig. Allergol. Clin. Immunol. 18, 357-365.
50. Warrington, K.H., Jr., Herzog, R.W. (2006). Treatment of human disease by adeno-associated viral gene transfer. Hum. Genet. 119, 571-603.
51. Weghofer, M., Thomas, W.R., Pittner, G., et al. (2005). Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions. Clin. Exp. Allergy 35, 1384-1391.
52. Wills-Karp, M. (1999). Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281.
53. Xue, Y.Q., Ma, B.F., Zhao, L.R., et al. (2010). AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease. Gene Ther. 17, 83-94.
54. Yang, S.C., and Lin, B.Y. (2010). Comparison of airway hyperreactivity in chronic obstructive pulmonary disease and asthma. Chang Gung Med. J. 33, 515-523.
55. Yang, C.J., Liu, Y.K., Liu, C.L., et al. (2009). Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses Ovalbumin-Sensitized Allergic Asthma. Hum. Gene Ther. 20, 1597-1606.
56. Zabner, J., Seiler, M., Walters, R., et al. (2000). Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. J. Virol. 74, 3852-3858.
57. Zavorotinskaya, T., Tomkinson, A., Murphy, J.E. (2003). Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13. Mol. Ther. 7, 155-162.