Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone

Canadian Journal of Emergency Medicine

Volumn 14, Issue 6, 2012, Pages 378-381

  Manara, Alessandro ^a   Hantson, Philippe ^b   Vanpee, Dominique ^a   Thys, Frédéric ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

Author keywords

Hyperlactatemia; Metabolic acidosis; Overdose; Salmeterol

Indexed keywords

FLUTICASONE PROPIONATE; HARTMANN SOLUTION; INFUSION FLUID; MONTELUKAST; SALMETEROL XINAFOATE; SODIUM CHLORIDE; ANDROSTANE DERIVATIVE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; FLUTICASONE; LACTIC ACID; POTASSIUM; SALBUTAMOL; SALMETEROL;

ACIDEMIA; ADOLESCENT; ADOLESCENT HEALTH; ARTICLE; ASTHMA; CASE REPORT; CLINICAL FEATURE; DIET SUPPLEMENTATION; DISEASE SEVERITY; DRUG EFFECT; DRUG OVERDOSE; DRUG SAFETY; ELECTROCARDIOGRAPHY; FEMALE; HEART PALPITATION; HUMAN; HYPERLACTATEMIA; HYPOKALEMIA; HYPOPHOSPHATEMIA; LABORATORY DIAGNOSIS; LACTIC ACIDOSIS; PH MEASUREMENT; POTASSIUM INTAKE; PSYCHOLOGIC ASSESSMENT; SINUS TACHYCARDIA; ST SEGMENT DEPRESSION; SUICIDE ATTEMPT; THORAX PAIN; ACIDOSIS, LACTIC; ANALOGS AND DERIVATIVES; BEHAVIOR; BLOOD; CHEMICALLY INDUCED; COMPLICATION; DRUG ADMINISTRATION; DRUG COMBINATION; FLUID THERAPY; INHALATIONAL DRUG ADMINISTRATION;

ACIDOSIS, LACTIC; ADMINISTRATION, INHALATION; ADOLESCENT; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; ANDROSTADIENES; ASTHMA; BRONCHODILATOR AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG OVERDOSE; DRUG THERAPY, COMBINATION; FEMALE; FLUID THERAPY; HUMANS; INTENTION; LACTIC ACID; POTASSIUM;

EID: 84869051660     PISSN: 14818035     EISSN: None     Source Type: Journal    
DOI: 10.2310/8000.2012.110581     Document Type: Article

References (13)

1. Cazzola M, Testi R, Matera MG. Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet 2002;41:19-30, doi:10. 2165/00003088-200241010-00003.
2. Richards SR, Chang FE, Stempel LE. Hyperlactacidemia associated with acute ritodrine infusion. Am J Obstet Gynecol 1983;146:1-5.
3. Rodrigo GJ, Rodrigo C. Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma. Emerg Med J 2005;22:404-408, doi:10.1136/emj.2003.012039.
4. Phillips PJ, Vedig AE, Jones PL, et al. Metabolic and cardiovascular side effects of the beta2-adrenoceptor agonistssalbutamol and rimiterol. Br J Clin Pharmacol 1980;9:483-491.
5. Tobin A, Pellizzer A, Santamaria JD. Mechanism by which systemic salbutamol increases ventilation. Respirology 2006; 11:182-187, doi:10.1111/j.1440-1843.2006.00832.x.
6. Veenith TV, Pearce A. A case of lactic acidosis complicating assessment and management of asthma. Int Arch Med 2008;1:3.
7. Manthous CA. Lactic acidosis in status asthmaticus. Three cases and review of the literature. Chest 2001;119:1599-1602, doi:10.1378/chest.119.5.1599.
8. Jee R, Brownlow H. Hyperlactaemia due to nebulised salbutamol. Anaesthesia 2007;62:751-752, doi:10.1111/j.1365-2044.2007.05160.x.
9. Haffner CA, Kendall MJ. Metabolic effects of beta2-agonists. J Clin Pharm Ther 1992;17:155-164, doi:10.1111/j.1365-2710.1992.tb01285.x
10. Creagh-Brown BC, Ball J. An under-recognized complication of treatment of acute severe asthma. Am J Emerg Med 2008;26:514.e1-e3, doi:10.1016/j.ajem.2007.07.035.
11. Salbutamol/salmeterol: lactic acidosis (first report with salmeterol) following inhalation: 2 case reports. Reactions Weekly 2010;1307:40.
12. Aronson JK, editor. Corticosteroids-glucocorticoids, inhaled. In: Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions. Oxford: Department of Primary Health Care; 2006. p. 958-977.
13. Bustos G, Ron AG, Ibarra della Rosa I, et al. Acidosis làctica secundaria a inhalacion de dosis elevadas de salbutamol. An Pediatr (Barc) 2008;69:577-592,doi:10.1016/S1695-4033(08)75243-3.