The robustness of the Escherichia coli signal-transducing UTase/UR-PII covalent modification cycle to variation in the PII concentration requires very strong inhibition of the UTase activity of UTase/UR by glutamine

Biochemistry

Volumn 51, Issue 45, 2012, Pages 9032-9044

  Jiang, Peng ^a   Zhang, Yaoping ^b   Atkinson, Mariette R ^a   Ninfa, Alexander J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; COVALENT MODIFICATIONS; HIS-TAG; MODIFICATION STATE; N-TERMINALS; SUBSTRATE INHIBITION; URIDYLYLTRANSFERASE; WILD TYPES; WILD-TYPE ENZYMES;

AMINO ACIDS; ESCHERICHIA COLI; PROTEINS; SUBSTRATES;

ENZYME INHIBITION;

ENZYME; GLUTAMINE; HEXOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; HISTIDINE; PHOSPHATE; UNCLASSIFIED DRUG; URIDYLYL REMOVING ENZYME;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME REGULATION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; WILD TYPE;

AMINO ACID SUBSTITUTION; ESCHERICHIA COLI; GLUTAMATE-AMMONIA LIGASE; GLUTAMINE; NUCLEOTIDYLTRANSFERASES; PII NITROGEN REGULATORY PROTEINS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

ESCHERICHIA COLI;

EID: 84869044041     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3005736     Document Type: Article

References (22)

1. Savageau, M. A. (1971) Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems Nature 229, 542-544
2. Kitano, H. (2007) Towards a theory of biological robustness Mol. Syst. Biol. 3, 137
3. Alon, U., Surette, M. G., Barkai, N., and Leibler, S. (1999) Robustness in bacterial chemotaxis Nature 397, 168-171
4. Shinar, G., Milo, R., Martinez, M. R. T., and Alon, U. (2007) Input-output robustness in simple bacterial signaling systems Proc. Natl. Acad. Sci. U.S.A. 104, 19931-19935
5. Soyer, O. S. and Pfeiffer, T. (2010) Evolution under fluctuating environments explains observed robustness in metabolic netwoorks PLoS Comput. Biol. 6, e10000907
6. Chock, P. B. and Stadtman, E. R. (1977) Superiority of interconvertable enzyme cascades in metabolic regulation: Analysis of multicyclic systems Proc. Natl. Acad. Sci. U.S.A. 74, 2766-2770
7. Gomez-Uribe, C., Verghese, G. C., and Mirny, L. A. (2007) Operating regimes of signaling cycles: Statics, dynamics, and noise filtering PLoS Comput. Biol. 3, e246
8. Cardenas, M. L. and Cornish-Bowden, A. (1989) Characteristics necessary for an interconvertible enzyme cascade to generate a highly sensitive response to an effector Biochem. J. 257, 339-345
9. Goldbeter, A. and Koshland, D. E. (1981) An amplified sensitivity arising from covalent modification in biological systems Proc. Natl. Acad. Sci. U.S.A. 78, 6840-6844
10. Koshland, D. E., J.r, Goldbeter, A., and Stock, J. B. (1982) Amplification and adaptation in regulatory and sensory systems Science 217, 220-225
11. Ninfa, A. J., Jiang, P., Atkinson, M. R., and Peliska, J. A. (2000) Integration of antagonistic signals in the regulation of nitrogen assimilation in Escherichia coli Curr. Top. Cell. Regul. 36, 31-75
12. Jiang, P., Peliska, J. A., and Ninfa, A. J. (1998) Enzymological characterization of the signal-transducing uridylyltransferase/uridylyl-removing enzyme (EC 2.7.7.59) of Escherichia coli and its interaction with the PII proteins Biochemistry 37, 12782-12794
13. Zhang, Y., Pohlmann, E. L., Conrad, M. C., and Roberts, G. P. (2010) Mutagenesis and functional characterization of the four domains of GlnD, a bifunctional nitrogen sensor protein J. Bacteriol. 192, 2711-2721
14. Ventura, A. C., Jiang, P., Van Wassenhove, L., Del Vecchio, D., Merajver, S. D., and Ninfa, A. J. (2010) Signaling properties of a covalent modification cycle are altered by a downstream target Proc. Natl. Acad. Sci. U.S.A. 107, 10032-10037
15. Kamberov, E. S., Atkinson, M. R., Chandran, P., Feng, J., and Ninfa, A. J. (1994) Sensory components controlling bacterial nitrogen assimilation Cell. Mol. Biol. Res. 40, 175-191
16. Schauder, B., Blocker, H., Frank, R., and McCarthy, J. E. (1987) Inducible expression vectors incorporating the E. coli atpE translational initiation region Gene 52, 279-283
17. Jiang, P. and Ninfa, A. J. (2012) Characterization of the Reconstituted UTase/UR-PII-NRII-NRI Bicyclic Signal Transduction System that Controls the Transcription of Nitrogen-Regulated (Ntr) Genes Biochemistry DOI: 10.1021/bi300575j
18. Guidi, G. M., Carlier, M. F., and Goldbeter, A. (1998) Bistability in the isocitrate dehydrogenase reaction: An experimentally based theoretical study Biophys. J. 74, 1229-1240
19. Kamberov, E. S., Atkinson, M. R., and Ninfa, A. J. (1995) The Escherichia coli PII signal transduction protein is activated upon binding 2-ketoglutarate and ATP J. Biol. Chem. 270, 17797-17807
20. Jiang, P., Mayo, A. E., and Ninfa, A. J. (2007) Escherichia coli glutamine synthetase adenylyltransferase (ATase, E.C. 2.7.7.49): Kinetic characterization of regulation by PII, PII-UMP, glutamine, and α-ketoglutarate Biochemistry 46, 4133-4146
21. Jiang, P., Pioszak, A. A., and Ninfa, A. J. (2007) Structure/function analysis of glutamine synthetase adenylyltransferase (ATase, E.C. 2.7.7.49) of Escherichia coli Biochemistry 46, 4117-4132
22. Stadtman, E. R. and Chock, P. B. (1977) Superiority of interconvertable enzyme cascades in metabolic regulation: Analysis of monocyclic systems Proc. Natl. Acad. Sci. U.S.A. 74, 2761-2765