Study of the electrical connection mechanism of sheathless interface for capillary electrophoresis-electrospray ionization-mass spectrometry

Journal of Mass Spectrometry

Volumn 47, Issue 11, 2012, Pages 1429-1434

  Tie, Cai ^a   Zhang, De Wen ^a   Chen, Hong Xu ^b   Song, Sen Lin ^c   Zhang, Xin Xiang ^a  

^a PEKING UNIVERSITY   (China)

^b BECKMAN COULTER INC   (United States)

^c Psychiatric Hospital   (China)

Author keywords

abused drug control; CE MS; electrical connection mechanism; high sensitivity; porous sheathless interface

Indexed keywords

6-MONOACETYLMORPHINE; ABUSED DRUGS; ANALYTES; ELECTRIC CONNECTIONS; ELECTRICAL CIRCUIT; ELECTRICAL CONNECTION; ELECTROCHEMICAL EXPERIMENTS; HIGH SENSITIVITY; POROUS WALLS; SEPARATION ABILITY; SMALL IONS; URINE SAMPLE;

CAPILLARY ELECTROPHORESIS; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY;

ELECTRIC CONNECTORS;

ION; MORPHINE; MORPHINE 6 ACETATE;

ARTICLE; CAPILLARY ELECTROPHORESIS; COMPUTER INTERFACE; ELECTRIC ACTIVITY; ELECTRIC POTENTIAL; ELECTRICAL CONNECTION MECHANISM; ELECTROCHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; INTEGRATED CIRCUIT; ION TRANSPORT; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SHEATHLESS INTERFACE; URINALYSIS;

DRUG STABILITY; ELECTROPHORESIS, CAPILLARY; HUMANS; IONS; LIMIT OF DETECTION; MODELS, CHEMICAL; MORPHINE; MORPHINE DERIVATIVES; POROSITY; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION;

EID: 84869041145     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3077     Document Type: Article

References (26)

1. M. A. Moseley, L. J. Deterding, K. B. Tomer, J. W. Jorgenson,. Capillary-zone electrophoresis/fast-atom bombardment mass spectrometry: design of an on-line coaxial continuous-flow interface. Rapid Commun. Mass Spectrom. 1989, 3, 87.
2. S. Pleasance, P. Thibault, J. Kelly,. Comparison of liquid-junction and coaxial interfaces for capillary electrophoresis mass-spectrometry with application to compounds of concern to the aquaculture industry. J. Chromatogr. 1992, 591, 325.
3. J. A. Olivares, N. T. Nguyen, C. R. Yonker, R. D. Smith,. Online mass-spectrometric detection for capillary zone electrophoresis. Anal. Chem. 1987, 59, 1230.
4. C. A. Nesbitt, H. X. Zhang, K. K. C. Yeung,. Recent applications of capillary electrophoresis-mass spectrometry (CE-MS): CE performing functions beyond separation. Anal. Chim. Acta 2008, 627, 3.
5. J. H. Wahl, D. C. Gale, R. D. Smith,. Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 [mu]m I.D. capillaries: Analyses of tryptic digests of cytochrome c. J. Chromatogr. A 1994, 659, 217.
6. A. P. Dahlin, M. Wetterhall, G. Liljegren, S. K. Bergstrom, P. Andren, L. Nyholm, K. E. Markides, J. Bergquist,. Capillary electrophoresis coupled to mass spectrometry from a polymer modified poly(dimethylsiloxane) microchip with an integrated graphite electrospray tip. Analyst 2005, 130, 193.
7. X. F. Zhu, S. Thiam, B. C. Valle, I. M. Warner,. A colloidal graphite-coated emitter for sheathless capillary electrophoresis/ nanoelectrospray ionization mass spectrometry. Anal. Chem. 2002, 74, 5405.
8. Y. Z. Chang, Y. R. Chen, G. R. Her,. Sheathless capillary electrophoresis/electrospray mass spectrometry using a carbon-coated tapered fused-silica capillary with a beveled edge. Anal. Chem. 2001, 73, 5083.
9. Y. Z. Chang, G. R. Her,. Sheathless capillary electrophoresis/ electrospray mass spectrometry using a carbon-coated fused silica capillary. Anal. Chem. 2000, 72, 626.
10. L. Bendahl, S. H. Hansen, J. Olsen,. A new sheathless electrospray interface for coupling of capillary electrophoresis to ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 2002, 16, 2333.
11. A. D. Zamfir, N. Dinca, E. Sisu, J. Peter-Katalinic,. Copper-coated microsprayer interface for on-line sheathless capillary electrophoresis electrospray mass spectrometry of carbohydrates. J. Sep. Sci. 2006, 29, 414.
12. Y. R. Chen, G. R. Her,. A simple method for fabrication of silver-coated sheathless electrospray emitters. Rapid Commun. Mass Spectrom. 2003, 17, 437.
13. Z. Kele, G. Ferenc, T. Klement, G. K. Toth, T. Janaky,. Design and performance of a sheathless capillary electrophoresis/mass spectrometry interface by combining fused-silica capillaries with gold-coated nanoelectrospray tips. Rapid Commun. Mass Spectrom. 2005, 19, 881.
14. S. Nilsson, O. Klett, M. Svedberg, A. Amirkhani, L. Nyholm,. Gold-coated fused-silica sheathless electrospray emitters based on vapor-deposited titanium adhesion layers. Rapid Commun. Mass Spectrom. 2003, 17, 1535.
15. R. S. Ramsey, S. A. McLuckey,. Capillary electrophoresis electrospray-ionization ion-trap mass-spectrometry using a sheathless interface. J. Microcolumn Sep. 1995, 7, 461.
16. S. Nilsson, M. Wetterhall, J. Bergquist, L. Nyholm, K. E. Markides,. A simple and robust conductive graphite coating for sheathless electrospray emitters used in capillary electrophoresis/mass spectrometry. Rapid Commun. Mass Spectrom. 2001, 15, 1997.
17. L. L. Fang, R. Zhang, E. R. Williams, R. N. Zare,. Online time-of-flight mass-spectrometric analysis of peptides separated by capillary electrophoresis. Anal. Chem. 1994, 66, 3696.
18. M. Moini,. Simplifying CE-MS operation. 2. Interfacing low-flow separation techniques to mass spectrometry using a porous tip. Anal. Chem. 2007, 79, 4241.
19. J.-M. Busnel, B. Schoenmaker, R. Ramautar, A. Carrasco-Pancorbo, C. Ratnayake, J. S. Feitelson, J. D. Chapman, A. M. Deelder, O. A. Mayboroda,. High Capacity Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry: Coupling a Porous Sheathless Interface with Transient-Isotachophoresis. Anal. Chem. 2010, 82, 9476.
20. A. Nguyen, M. Moini,. Analysis of major protein-protein and protein-metal complexes of erythrocytes directly from cell lysate utilizing capillary electrophoresis mass spectrometry. Anal. Chem. 2008, 80, 7169.
21. M. Moini,. Metal displacement and stoichiometry of protein-metal complexes under native conditions using capillary electrophoresis/mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24, 2730.
22. R. Haselberg, C. K. Ratnayake, G. J. de Jong, G. W. Somsen,. Performance of a sheathless porous tip sprayer for capillary electrophoresis-electrospray ionization-mass spectrometry of intact proteins. J. Chromatogr. A 2010, 1217, 7605.
23. D. Shental-Bechor, Y. Levy,. Folding of glycoproteins: toward understanding the biophysics of the glycosylation code. Curr. Opin. Struct. Biol. 2009, 19, 524.
24. A. B. Wey, W. Thormann,. Head-column field-amplified sample stacking in presence of siphoning-Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine. J. Chromatogr. A 2001, 924, 507.
25. P. Wernly, W. Thormann,. Drug of abuse confirmation in human urine using stepwise solid-phase extraction and micellar electrokinetic capillary chromatography. Anal. Chem. 1992, 64, 2155.
26. M. Katagi, M. Nishikawa, M. Tatsuno, A. Miki, H. Tsuchihashi,. Column-switching high-performance liquid chromatography-electrospray ionization mass spectrometry for identification of heroin metabolites in human urine. J. Chromatogr. B 2001, 751, 177.