Intranasal treatment with poly(I·C) protects aged mice from lethal respiratory virus infections

Journal of Virology

Volumn 86, Issue 21, 2012, Pages 11416-11424

  Zhao, Jincun ^a   Wohlford Lenane, Christine ^a   Zhao, Jingxian ^a,b   Fleming, Erica ^a   Lane, Thomas E ^c   McCray, Paul B ^a   Perlman, Stanley ^a  

^a UNIVERSITY OF IOWA   (United States)

^b JINAN UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; IMIDAZOQUINOLINE DERIVATIVE; INTERLEUKIN 1BETA; POLYINOSINIC POLYCYTIDYLIC ACID; RESIQUIMOD; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DIAPHORESIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; INFECTION PREVENTION; INFLUENZA A; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; TREATMENT RESPONSE; VIRUS LOAD; VIRUS REPLICATION; WEIGHT REDUCTION;

EID: 84869023304     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01410-12     Document Type: Article

References (36)

1. Butowski N, et al. 2009. A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05). J. Neurooncol.91:175-182.
2. Cameron MJ, et al. 2007. Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J. Virol. 81:8692-8706.
3. Caskey M, et al. 2011. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J. Exp. Med. 208:2357-2366.
4. de Jong MD, et al. 2006. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat. Med. 12:1203-1207.
5. Ely KH, Roberts AD, Kohlmeier JE, Blackman MA, Woodland DL.2007. Aging and CD8+ T cell immunity to respiratory virus infections.Exp. Gerontol. 42:427-431.
6. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. 2005.Respiratory syncytial virus infection in elderly and high-risk adults. N.Engl. J. Med. 352:1749 -1759.
7. Frieman MB, et al. 2010. SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism. PLoS Pathog. 6:e1000849. doi:10.1371/journal.ppat.1000849.
8. Hosking MP, Liu L, Ransohoff RM, Lane TE. 2009. A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathog.5:e1000648. doi:10.1371/journal.ppat.1000648.
9. Jia HP, et al. 2005. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway pithelia. J. Virol. 79:14614 -14621.
10. Jiang J, et al. 2009. Limited expansion of virus-specific CD8 T cells in the aged environment. Mech. Ageing Dev. 130:713-721.
11. Karp PH, et al. 2002. An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures. Methods Mol. Biol.188:115-137.
12. Katz JM, et al. 2004. Immunity to influenza: the challenges of protecting an aging population. Immunol. Res. 29:113-124.
13. Kobasa D, et al. 2007. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:319 -323.
14. Kovacs EJ, et al. 2009. Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors. Trends Immunol. 30:319 -324.
15. Krown SE, Kerr D, Stewart WE, Jr, Field AK, Oettgen HF. 1985. Phase I trials of poly(I,C) complexes in advanced cancer. J. Biol. Response Mod.4:640-649.
16. Legge KL, Braciale TJ. 2005. Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression. Immunity 23:649-659.
17. Meylan E, Tschopp J, Karin M. 2006. Intracellular pattern recognition receptors in the host response. Nature 442:39-44.
18. Moltedo B, et al. 2009. Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity. J. Immunol. 183:3569-3573.
19. Murasko DM, Jiang J. 2005. Response of aged mice to primary virus infections. Immunol. Rev. 205:285-296.
20. Nagata N, et al. 2008. Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice. Am. J. Pathol. 172:1625-1637.
21. Nicholls JM, et al. 2006. Time course and cellular localization of SARSCoV nucleoprotein andRNAin lungs from fatal cases of SARS. PLoS Med.3:e27. doi:10.1371/journal.pmed.0030027.
22. Okada H, et al. 2011. Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with α-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma. J. Clin. Oncol. 29:330 -336.
23. Peiris JS, Guan Y, Yuen KY. 2004. Severe acute respiratory syndrome.Nat. Med. 10:S88 -S97.
24. Roberts A, et al. 2007. A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice. PLoS Pathog. 3:e5. doi:10.1371/journal.ppat.0030005.
25. Rockx B, et al. 2009. Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection. J.Virol. 83:7062-7074.
26. Seya T, Matsumoto M. 2009. The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer. Cancer Immunol. Immunother. 58:1175-1184.
27. Smits SL, et al. 2010. Exacerbated innate host response to SARS-CoV in aged non-human primates. PLoS Pathog. 6:e1000756. doi:10.1371/journal.ppat.1000756.
28. Subbarao K, Roberts A. 2006. Is there an ideal animal model for SARS?Trends Microbiol. 14:299 -303.
29. Takeuchi O, Akira S. 2008. MDA5/RIG-I and virus recognition. Curr.Opin. Immunol. 20:17-22.
30. Teijaro JR, et al. 2011. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell 146:980-991.
31. Toapanta FR, Ross TM. 2009. Impaired immune responses in the lungs of aged mice following influenza infection. Respir. Res. 10:112.
32. Yager EJ, et al. 2008. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.J. Exp. Med. 205:711-723.
33. Zhao J, Zhao J, Legge K, Perlman S. 2011. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J. Clin.Investig. 121:4921-4930.
34. Zhao J, Zhao J, Perlman S. 2010. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J. Virol. 84:9318-9325.
35. Zhao J, Zhao J, Van Rooijen N, Perlman S. 2009. Evasion by stealth:inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog. 5:e1000636. doi:10.1371/journal.ppat.1000636.
36. Zhou H, Zhao J, Perlman S. 2010. Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine productionafter coronavirus infection. mBio 1:e00219-10.doi:10.1128/mBio.00219-10.