Quantification of trans-2,6-difluoro-4'-N,N-dimethylaminostilbene in rat plasma: Application to a pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 72, Issue , 2013, Pages 115-120

  Lin, Hai Shu ^a   Sviripa, Vitaliy M ^b   Watt, David S ^b   Liu, Chunming ^b   Xiang, Tian Xiang ^c   Anderson, Bradley D ^c   Ong, Pei Shi ^a   Ho, Paul C ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Absolute oral bioavailability; Dose escalation; HPLC; Pharmacokinetics; Trans 2,6 Difluoro 4' N,N dimethylaminostilbene

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2,6 DIFLUORO 4' N,N DIMETHYLAMINOSTILBENE; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPRAGUE DAWLEY RAT; SUSPENSION; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; INFUSIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STILBENES;

EID: 84869023256     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.09.027     Document Type: Article

References (13)

1. Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5:493-506.
2. Zhang W., Sviripa V., Kril L.M., Chen X., Yu T., Shi J., Rychahou P., Evers B.M., Watt D.S., Liu C. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J. Med. Chem. 2011, 54:1288-1297.
3. Lin H.S., Choo Q.Y., Ho P.C. Quantification of oxyresveratrol analog trans-2,4,3',5'-tetramethoxystilbene in rat plasma by a rapid HPLC method: application in a pre-clinical pharmacokinetic study. Biomed. Chromatogr. 2010, 24:1373-1378.
4. Lin H.S., Ho P.C. Preclinical pharmacokinetic evaluation of resveratrol trimethyl ether in Sprague-Dawley rats: the impacts of aqueous solubility, dose escalation, food and repeated dosing on oral bioavailability. J. Pharm. Sci. 2011, 100:4491-4500.
5. Lin H.S., Spatafora C., Tringali C., Ho P.C. Determination of trans-2,4,3',4',5'-pentamethoxystilbene in rat plasma and its application to a pharmacokinetic study. J. Pharm. Biomed. Anal. 2012, 57:94-98.
6. Lin H.S., Tringali C., Spatafora C., Choo Q.Y., Ho P.C. LC determination of trans-3,5,3',4',5'-pentamethoxystilbene in rat plasma. Chromatographia 2010, 72:827-832.
7. Lin H.S., Tringali C., Spatafora C., Wu C., Ho P.C. A simple and sensitive HPLC-UV method for the quantification of piceatannol analog trans-3,5,3',4'-tetramethoxystilbene in rat plasma and its application for a pre-clinical pharmacokinetic study. J. Pharm. Biomed. Anal. 2010, 51:679-684.
8. Lin H.S., Yue B.D., Ho P.C. Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study. Biomed. Chromatogr. 2009, 23:1308-1315.
9. Lin H.S., Zhang W., Go M.L., Tringali C., Spatafora C., Ho P.C. Quantification of trans-3,4,5,4'-Tetramethoxystilbene in rat plasma by HPLC: application to pharmacokinetic study. J. Agric. Food. Chem. 2011, 59:1072-1077.
10. FDA, Guidance for Industry, Bioanalytical Method Validation, 2001.
11. Das S., Lin H.S., Ho P.C., Ng K.Y. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm. Res. 2008, 25:2593-2600.
12. Lin H.S., Ho P.C. A rapid HPLC method for the quantification of 3,5,4'-trimethoxy-trans-stilbene (TMS) in rat plasma and its application in pharmacokinetic study. J. Pharm. Biomed. Anal. 2009, 49:387-392.
13. Lin H.S., Zhang W., Go M.L., Choo Q.Y., Ho P.C. Determination of Z-3,5,4'-trimethoxystilbene in rat plasma by a simple HPLC method: Application in a pre-clinical pharmacokinetic study. J. Pharm. Biomed. Anal. 2010, 53:693-697.