First Discovery of Two Polyketide Synthase Genes for Mitorubrinic Acid and Mitorubrinol Yellow Pigment Biosynthesis and Implications in Virulence of Penicillium marneffei

PLoS Neglected Tropical Diseases

Volumn 6, Issue 10, 2012, Pages

  Woo, Patrick C Y ^a,b   Lam, Ching Wan ^b   Tam, Emily W T ^a   Leung, Chris K F ^b   Wong, Samson S Y ^a,b   Lau, Susanna K P ^a,b   Yuen, Kwok Yung ^a,b  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; HYDROGEN PEROXIDE; MITORUBRINIC ACID; MITORUBRINOL; NONRIBOSOMAL PEPTIDE SYNTHETASE; PIGMENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CELL SURVIVAL; CONIDIUM; CONTROLLED STUDY; DNA EXTRACTION; ELECTROSPRAY MASS SPECTROMETRY; FUNGAL GENE; FUNGAL VIRULENCE; FUNGUS MUTANT; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PENICILLIUM MARNEFFEI; PHYLOGENY; POLYKETIDE SYNTHASE GENE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; BENZOATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; MICE; MICE, INBRED BALB C; MYCOSES; PENICILLIUM; PIGMENTS, BIOLOGICAL; POLYKETIDE SYNTHASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURVIVAL ANALYSIS; TANDEM MASS SPECTROMETRY; VIRULENCE; VIRULENCE FACTORS;

EID: 84869008412     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001871     Document Type: Article

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