The fate of Treponema denticola within human gingival epithelial cells

Molecular Oral Microbiology

Volumn 27, Issue 6, 2012, Pages 471-482

  Shin, J ^a   Choi, Y ^a  

^a Seoul National University   (South Korea)

Author keywords

Endosome; Gingival epithelial cells; Invasion; Lysosome; Survival; Treponema denticola

Indexed keywords

ANTIBIOTIC AGENT; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; REACTIVE OXYGEN METABOLITE; RNA 16S;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL SURVIVAL; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; CELL IMMORTALIZATION; CELL LINE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGRADATION; ENDOSOME; EPITHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GINGIVA; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; MOUTH MUCOSA; NONHUMAN; PATHOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; TREPONEMA DENTICOLA; TREPONEMATOSIS;

ANTI-BACTERIAL AGENTS; CELL LINE; ENDOSOMES; ENTOSIS; EPITHELIAL CELLS; FLOW CYTOMETRY; FLUORESCEINS; FLUORESCENT DYES; GINGIVA; HUMANS; KERATINOCYTES; MICROBIAL VIABILITY; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S; SUCCINIMIDES; TIME FACTORS; TREPONEMA DENTICOLA;

EID: 84869004712     PISSN: 20411006     EISSN: 20411014     Source Type: Journal    
DOI: 10.1111/j.2041-1014.2012.00660.x     Document Type: Article

References (40)

1. Alonso, A. and Garcia-del Portillo, F. (2004) Hijacking of eukaryotic functions by intracellular bacterial pathogens. Int Microbiol7: 181-191.
2. Dale, B.A. (2002) Periodontal epithelium: a newly recognized role in health and disease. Periodontol 200030: 70-78.
3. Dorn, B.R., Dunn, W.A. Jr and Proqulske-Fox, A. (2001) Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells. Infect Immun69: 5698-5708.
4. Duncan, M.J., Nakao, S., Skobe, Z. and Xie, H. (1993) Interactions of Porphyromonas gingivalis with epithelial cells. Infect Immun61: 2260-2265.
5. Ehrt, S. and Schnappinger, D. (2009) Mycobacterial survival strategies in the phagosomes: defence against host stresses. Cell Microbiol11: 1170-1178.
6. Feng, Z. and Weinberg, A. (2006) Role of bacteria in health and disease of periodontal tissues. Periodontol 200040: 50-76.
7. Fietta, P. and Delsante, G. (2009) The effector T helper cell triad. Riv Biol102: 61-74.
8. Gouin, E., Gantelet, H., Eqile, C. et al. (1999) A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii. J Cell Sci112: 1697-1708.
9. Gutierrez, M.G., Vazquez, C.L., Munafo, D.B. et al. (2005) Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles. Cell Microbiol7: 981-993.
10. Haffajee, A.D., Teles, R.P. and Socransky, S.S. (2006) Association of Eubacterium nodatum and Treponema denticola human periodontitis lesions. Oral Microbiol Immunol21: 269-282.
11. Haffajee, A.D., Socransky, S.S., Patel, M.R. and Song, X. (2008) Microbial complexes in supragingival plaque. Oral Microbiol Immunol23: 196-205.
12. Hunfeld, K.P., Kraiczy, P., Wichelhaus, T.A., Schäfer, V. and Brade, V. (2000) New colorimetric microdilution method for in vitro susceptibility testing of Borrelia burgdorferi against antimicrobial substances. Eur J Clin Microbiol Infect Dis19: 27-32.
13. Ishihara, K. and Okuda, K. (1999a) Molecular pathogenesis of the cell surface proteins and lipids from Treponema denticola. FEMS Microbiol Lett15: 199-204.
14. Ishihara, K. and Okuda, K. (1999b) Molecular analysis for pathogenicity of oral treponemes. Microbiol Immunol43: 495-503.
15. Jacob, E. and Nauman, R.K. (1982) Common antigens of Treponema denticola: chemical, physical, and serological characterization. Infect Immun37: 474-480.
16. Ji, S., Kim, Y.S., Min, B.-M., Han, S.H. and Choi, Y. (2007) Innate immune responses of gingival epithelial cells to non-periodontopathic and periodontopathic bacteria. J Periodontal Res42: 503-510.
17. Ji, S., Shin, J.E., Kim, Y.C. and Choi, Y. (2010) Intracellular degradation of Fusobacterium nucleatum in human gingival epithelial cells. Mol Cells30: 519-526.
18. Kim, Y.C., Ko, Y., Hong, S.D. and Choi, Y. (2010) Presence of Porphyromonas gingivalis and plasma cell dominance in gingival tissue with periodontitis. Oral Dis16: 375-381.
19. Kim, Y., Jo, A.R., Jang, D.H. et al. (in press) Toll-like receptor 9 mediates oral bacteria-induced IL-8 expression in gingival epithelial cells. Immunol Cell Biol. Doi: 10.1038/icb.2011.85.
20. Lamont, R.T. and Yimaz, O. (2002) In or out: the invasiveness of oral bacteria. Periodontol 200030: 61-69.
21. Lamont, R.J., Oda, D., Persson, R.E. and Persson, G.R. (1992) Interaction of Porphyromonas gingivalis with gingival epithelial cells maintained in culture. Oral Microbiol Immunol7: 364-367.
22. Lamont, R.J., Chan, A., Belton, C.M., Izutsu, K.T., Vasel, D. and Weinberg, A. (1995) Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun63: 3878-3885.
23. Loesche, W.J. and Grossman, N.S. (2001) Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev14: 727-752.
24. Lux, R., Miller, J.N., Park, N.H. and Shi, W. (2001) Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola. Infect Immun69: 6276-6283.
25. Madianos, P.N., Papapanous, P.N., Nannmark, U., Dahlen, G. and Sandros, J. (1996) Porphyromonas gingivalis FDC381 multiplies and persists within human oral epithelial cells in vitro. Infect Immun64: 660-664.
26. McHardy, I., Keegan, C., Sim, J.H., Shi, W. and Lux, R. (2010) Transcriptional profiles of Treponema denticola in response to environmental conditions. PLoS ONE5: e13655.
27. Meresse, S., Steele-Mortimer, O., Moreno, E., Desiardins, M., Finlay, B. and Gorvel, J.P. (1999) Controlling the maturation of pathogen containing vacuoles: a matter of life and death. Nat Cell Biol1: E183-E188.
28. Meyer, D.H., Lippmann, J.E. and Fives-Taylor, P.M. (1996) Invasion of epithelial cells by Actinobacillus actinomycetemcomitans: a dynamic, multistep process. Infect Immun64: 2988-2997.
29. Nakagawa, I., Amano, A., Mizushima, N. et al. (2004) Autophagy defends cells against invading group A Streptococcus. Science306: 1037-1040.
30. Nishihara, T. and Koseki, T. (2004) Microbial etiology of periodontitis. Periodontol 200036: 14-26.
31. Orth, R., O'Brien-Simpson, N., Dashper, S., Walsh, K. and Reynolds, E. (2010) An efficient method for enumerating oral spirochetes using flow cytometry. J Microbiol Methods80: 123-128.
32. Sandros, J., Papapanous, P.N., Nannmark, U. and Dahlen, G. (1994) Porphyromonas gingivalis invades human pocket epithelium in vitro. J Periodontal Res29: 62-69.
33. Sela, M.N. (2001) Role of Treponema denticola in periodontal diseases. Crit Rev Oral Biol Med12: 399-413.
34. Seshadri, R., Myers, G.S., Tettelin, H. et al. (2004) Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc Natl Acad Sci U S A101: 5646-5651.
35. Shin, J.E., Kim, Y.S., Oh, J.E., Min, B.M. and Choi, Y. (2010) Treponema denticola suppresses expression of human beta-defensin-3 in gingival epithelial cells through inhibition of TLR2 activation axis. Infect Immun78: 672-679.
36. Socransky, S.S., Haffajee, A.D., Cugini, M.A., Smith, C. and Kent, R.L. Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol25: 134-144.
37. Song, E., Jaishankar, G.B., Saleh, H., Jithpratuck, W., Sahni, R. and Krishnaswamy, G. (2011) Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy31: 10.
38. Wang, M. and Hajishenqallis, G. (2008) Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages. Cell Microbiol10: 2029-2042.
39. Yilmaz, O., Jungas, T., Verbeke, P. and Ojcius, D.M. (2004) Activation of the phosphatidylinositol 3-kinase/Akt-pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis. Infect Immun72: 3743-3751.
40. Yilmaz, O., Verbeke, P., Lamont, R.J. and Ojcius, D.M. (2006) Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells. Infect Immun74: 703-710.