Does PDE4 inhibition improve alveolarisation in hyperoxia-exposed immature rodents?

European Respiratory Journal

Volumn 33, Issue 5, 2009, Pages 1236-

  Mehats C ^a,b   Bourbon, J ^b,d   Jarreau, P H ^a,b,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Service de Médecine Néonatale de Port Royal ^*  (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d INSERM U955   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CILOMILAST; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM;

DRUG EFFECT; DRUG INHIBITION; HYPEROXIA; LETTER; LUNG DYSPLASIA; MALNUTRITION; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CARBOXYLIC ACIDS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HYPEROXIA; LUNG COMPLIANCE; MICE; MICE, INBRED C57BL; NITRILES; PHOSPHODIESTERASE INHIBITORS; PULMONARY ALVEOLI; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84868973563     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00002809     Document Type: Letter

References (4)

1. Woyda K, Koebrich S, Reiss I, et al. Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia. Eur Respir J 2009; 33: 861-870.
2. Mehats C, Franco-Montoya ML, Boucherat O, et al. Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats. PLoS ONE 2008; 3: e3445.
3. de Visser YP, Walther FJ, Laghmani EH, van Wijngaarden S, Nieuwland K, Wagenaar GT. Phosphodiesterase 4 inhibition attenuates pulmonary inflammation in neonatal lung injury. Eur Respir J 2007; 31: 633-644.
4. Weibel ER, Cruz-Orive LM. Morphometric methods. In: Crystal RG, West JB, Weibel ER, Barnes PJ, eds. The Lung: Scientific Foundations. Philadelphia, Lippincott-Raven, 1997; pp. 333-344.