A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4% formalin application for treatment of hemorrhagic radiation proctitis

Diseases of the Colon and Rectum

Volumn 55, Issue 10, 2012, Pages 1053-1058

  Sahakitrungruang, Chucheep ^a   Patiwongpaisarn, Attaporn ^a   Kanjanasilp, Prapon ^a   Malakorn, Songphol ^a   Atittharnsakul, Puttarat ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Formalin; Hemorrhagic radiation proctitis; Oral antibiotic administration; Randomized controlled trial; Selfadministered colonic irrigation; Treatment

Indexed keywords

CIPROFLOXACIN; FORMALDEHYDE; METRONIDAZOLE; OXYGEN; TAP WATER;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; COLON LAVAGE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEFECATION URGENCY; DIARRHEA; DRUG SELF ADMINISTRATION; FEMALE; HEMATOCRIT; HEMORRHAGIC RADIATION PROCTITIS; HUMAN; HYPERBARIC OXYGEN; MALE; NAUSEA; OUTCOME ASSESSMENT; PATIENT SATISFACTION; PROCTITIS; PROSTATE CANCER; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; RECTOSCOPY; RECTUM HEMORRHAGE; TENESMUS; TERTIARY HEALTH CARE; TREATMENT DURATION; TREATMENT OUTCOME; UTERINE CERVIX CANCER; UTERUS CANCER; VAGINA CANCER;

ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; CHI-SQUARE DISTRIBUTION; CIPROFLOXACIN; FEMALE; FORMALDEHYDE; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; METRONIDAZOLE; MIDDLE AGED; PROCTITIS; PROCTOSCOPY; QUESTIONNAIRES; RADIATION INJURIES; STATISTICS, NONPARAMETRIC; THERAPEUTIC IRRIGATION; TREATMENT OUTCOME;

EID: 84868704116     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0b013e318265720a     Document Type: Article

References (26)

1. Wang CJ, Leung SW, Chen HC, et al. The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinoma: evidence suggestive of consequential late effect (CQLE). Int J Radiat Oncol Biol Phys. 1998;40:85-91. (Pubitemid 28027571)
2. Heemsbergen WD, Peeters ST, Koper PC, Hoogeman MS, Lebesque JV. Acute and late gastrointestinal toxicity after radiotherapy in prostate cancer patients: consequential late damage. Int J Radiat Oncol Biol Phys. 2006;66:3-10. (Pubitemid 44175664)
3. Babb RR. Radiation proctitis: a review. Am J Gastroenterol. 1996;91:1309-1311. (Pubitemid 26236359)
4. Goldstein F, Khoury J, Thornton JJ. Treatment of chronic radiation enteritis and colitis with salicylazosulfapyridine and systemic corticosteroids: a pilot study. Am J Gastroenterol. 1976;65:201-208.
5. Kochhar R, Sharma SC, Gupta BB, Mehta SK. Rectal sucralfate in radiation proctitis. Lancet. 1988;2:400.
6. Denton AS, Andreyev HJ, Forbes A, Maher EJ. Systematic review for non-surgical interventions for the management of late radiation proctitis. Br J Cancer. 2002;87:134-143.
7. Girnius S, Cersonsky N, Gesell L, Cico S, Barrett W. Treatment of refractory radiation-induced hemorrhagic proctitis with hyperbaric oxygen therapy. Am J Clin Oncol. 2006;29:588-592. (Pubitemid 44915295)
8. Mathai V, Seow-Choen F. Endoluminal formalin therapy for haemorrhagic radiation proctitis. Br J Surg. 1995;82:190.
9. Tjandra JJ, Sengupta S. Argon plasma coagulation is an effective treatment for refractory hemorrhagic radiation proctitis. Dis Colon Rectum. 2001;44:1759-1765. (Pubitemid 34031431)
10. Ayerdi J, Moinuddeen K, Loving A, Wiseman J, Deshmukh N. Diverting loop colostomy for the treatment of refractory gastrointestinal bleeding secondary to radiation proctitis. Mil Med. 2001;166:1091-1093. (Pubitemid 34015291)
11. Lucarotti ME, Mountford RA, Bartolo DC. Surgical management of intestinal radiation injury. Dis Colon Rectum. 1991;34:865-869.
12. Pikarsky AJ, Belin B, Efron J, Weiss EG, Nogueras JJ, Wexner SD. Complications following formalin installation in the treatment of radiation induced proctitis. Int J Colorectal Dis. 2000;15:96-99.
13. de Parades V, Etienney I, Bauer P, et al. Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis-an effective but not risk-free procedure: a prospective study of 33 patients. Dis Colon Rectum. 2005;48:1535-1541. (Pubitemid 41032076)
14. Sahakitrungruang C, Thum-Umnuaysuk S, Patiwongpaisarn A, Atittharnsakul P, Rojanasakul A. A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. Colorectal Dis. 2011;13:e79-e82.
15. Wachter S, Gerstner N, Goldner G, Pötzi R, Wambersie A, Pötter R. Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma. Radiother Oncol. 2000;54:11-19. (Pubitemid 30055321)
16. Hasleton PS, Carr N, Schofield PF. Vascular changes in radiation bowel disease. Histopathology. 1985;9:517-534. (Pubitemid 15025903)
17. Manner H, Plum N, Pech O, Ell C, Enderle MD. Colon explosion during argon plasma coagulation. Gastrointest Endosc. 2008;67:1123-1127. (Pubitemid 351728114)
18. Oliai C, Fisher B, Jani A, et al. Hyperbaric oxygen therapy for radiation-induced cystitis and proctitis [published online ahead of print March 20, 2012]. Int J Radiat Oncol Biol Phys. doi: 10.1016/j.ijrobp.2011.12.056.
19. Shrom SH, Donaldson MH, Duckett JW, Wein AJ. Formalin treatment for intractable hemorrhagic cystitis: a review of the literature with 16 additional cases. Cancer. 1976;38: 1785-1789.
20. Luna-Pérez P, Rodríguez-Ramírez SE. Formalin instillation for refractory radiation-induced hemorrhagic proctitis. J Surg Oncol. 2002;80:41-44. (Pubitemid 34477734)
21. Trott KR, Breiter N, Spiethoff A. Experimental studies on the pathogenesis of the chronic radiation ulcer of the large bowel in rats. Int J Radiat Oncol Biol Phys. 1986;12:1637-1643. (Pubitemid 17175251)
22. Cavcic J, Turcic J, Martinac P, et al. Metronidazole in the treatment of chronic radiation proctitis: clinical trial. Croat Med J. 2000;41:314-318.
23. Thong BY. Update on the management of antibiotic allergy. Allergy Asthma Immunol Res. 2010;2:77-86.
24. Asha NJ, Tompkins D, Wilcox MH. Comparative analysis of prevalence, risk factors, and molecular epidemiology of antibiotic- associated diarrhea due to Clostridium difficile, Clostridium perfringens, and Staphylococcus aureus. J Clin Microbiol. 2006;44:2785-2791. (Pubitemid 44228572)
25. Paran H, Butnaru G, Neufeld D, Magen A, Freund U. Enemainduced perforation of the rectum in chronically constipated patients. Dis Colon Rectum. 1999;42:1609-1612. (Pubitemid 30007597)
26. Handley DV, Rieger NA, Rodda DJ. Rectal perforation from colonic irrigation administered by alternative practitioners. Med J Aust. 2004;181:575-576. (Pubitemid 39545639)