Association between the synovial expression of cyclic citrullinated peptide and susceptibility variants of HLA-DRB1 shared epitope alleles and PADI 4 gene single nucleotide polymorphisms in patients with rheumatoid arthritis

National Medical Journal of China

Volumn 92, Issue 23, 2012, Pages 1607-1611

  Li, Hong Bin ^a   Tie, Ning ^a   Jia, Yong Feng ^a   Shi, Lin ^a   Su, Yan ^b   Zhang, Gui Zhi ^a   Wang, Yong ^a   Bai, Li Jie ^a   Zhao, Jing ^a   Wang, Jing ^a   Xiao, Zhen ^a  

^a INNER MONGOLIA MEDICAL COLLEGE   (China)

^b NONE

Author keywords

Arginase; Arthritis, rheumatoid; HLA Antigen

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HLA DRB1 ANTIGEN; PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE 4; UNCLASSIFIED DRUG;

ALLELE; ANTIBODY PRODUCTION; ARTICLE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA SEQUENCE; GENOTYPE; HAPLOTYPE; HUMAN; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYNOVIAL FLUID; SYNOVIUM;

ADULT; ALLELES; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; EPITOPES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DRB1 CHAINS; HUMANS; HYDROLASES; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; POLYMORPHISM, SINGLE NUCLEOTIDE; SYNOVIAL MEMBRANE; YOUNG ADULT;

EID: 84868700453     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2012.23.007     Document Type: Article

References (14)

1. 2006, 86: 2182-2187.
2. van V W J, van B J J, Pruijn G J. Anti-CCP antibodies: the past, the present and the future. Nat Rev Rheumatol, 2011, 7: 391-398.
3. Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet, 2003, 34; 395-402.
4. Raats J M, Wijnen E M, Pruijn G J, et al. Recombinant human monoclonal autoantibodies specific for citrulline-containing peptides from phage display libraries derived from patients with rheumatoid arthritis. J Rheumatol, 2003, 30: 1696-1711.
5. 2010, 49: 614-617.
6. Zetterquist H, Olerup O. Identification of the HLA-DRB1 * 04, -DRB1 * 07, and -DRB1 * 09 alleles by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Hum Immunol, 1992, 34: 64-74.
7. Kuhn K A, Kulik L, Tomooka B, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest, 2006, 116: 961-973.
8. Ioan-Facsinay A, el-Bannoudi H, Scherer H U, et al. Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities. Ann Rheum Dis, 2011, 70: 188-193.
9. Baeten D, Peene I, Union A, et al. Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum, 2001, 44: 2255-2262.
10. Vossenaar E R, Smeets T J, Kraan M C, et al. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue. Arthritis Rheum, 2004, 50: 3485-3494.
11. Hill J A, Bell D A, Brintnell W, et al. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med, 2008, 205: 967-979.
12. 2009, 26: 57-61.
13. Chang X, Yamada R, Suzuki A, et al. Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology, 2005, 44: 40-50.
14. Cha S, Choi C B, Han T U, et al. Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis. Arthritis Rheum, 2007, 56: 1454-1463.