Diminazene Aceturate (Berenil) Modulates the Host Cellular and Inflammatory Responses to Trypanosoma congolense Infection

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Kuriakose, Shiby ^a   Muleme, Helen M ^a   Onyilagha, Chukwunonso ^a   Singh, Rani ^a   Jia, Ping ^a   Uzonna, Jude E ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; DIMINAZENE ACETURATE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE STORM; DISEASE EXACERBATION; DRUG ACTIVITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; IMMUNE RESPONSE; INFLAMMATION; LIVER CELL; MACROPHAGE; MOUSE; NAGANA; NONHUMAN; REGULATORY T LYMPHOCYTE; RISK REDUCTION; SEPTIC SHOCK; SPLEEN CELL; TRYPANOSOMA CONGOLENSE;

ANIMALS; CYTOKINES; DIMINAZENE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNITY, CELLULAR; INFLAMMATION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KUPFFER CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN; T-LYMPHOCYTES; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; BOS; MUS; TRYPANOSOMA CONGOLENSE;

EID: 84868697704     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048696     Document Type: Article

References (29)

1. Magez S, Schwegmann A, Atkinson R, Claes F, Drennan M, et al. (2008) The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog 4: e1000122.
2. Pan W, Ogunremi O, Wei G, Shi M, Tabel H, (2006) CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide. Microbes Infect 8: 1209-1218.
3. Tomlinson S, Raper J, (1998) Natural human immunity to trypanosomes. Parasitol Today 14: 354-359.
4. Taylor KA, Lutje V, Kennedy D, Authie E, Boulange A, et al. (1996) Trypanosoma congolense: B-lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle. Exp Parasitol 83: 106-116.
5. Tabel H, Wei G, Shi M, (2008) T cells and immunopathogenesis of experimental African trypanosomiasis. Immunol Rev 225: 128-139.
6. PM Kristjanson BM Swallow, GJ Rowlands, RL Kruska, PN de Leeuw, (1999) Measuring the costs of Africananimaltrypanosomosis, the potentialbenefits of control and returns to research. Agricultural Systems 59: 79.
7. Naylor DC, (1971) The haematology and histopathology of Trypanosoma congolense infection in cattle. I. Introduction and histopathology. Trop Anim Health Prod 3: 95-100.
8. Uzonna JE, Kaushik RS, Gordon JR, Tabel H, (1998) Experimental murine Trypanosoma congolense infections. I. Administration of anti-IFN-gamma antibodies alters trypanosome-susceptible mice to a resistant-like phenotype. J Immunol 161: 5507-5515.
9. Tabel H, Kaushik RS, Uzonna JE, (2000) Susceptibility and resistance to Trypanosoma congolense infections. Microbes Infect 2: 1619-1629.
10. Shi M, Wei G, Pan W, Tabel H, (2004) Trypanosoma congolense infections: antibody-mediated phagocytosis by Kupffer cells. J Leukoc Biol 76: 399-405.
11. Brack C, Delain E, Riou G, Festy B, (1972) Molecular organization of the kinetoplast DNA of Trypanosoma cruzi treated with berenil, a DNA interacting drug. J Ultrastruct Res 39: 568-579.
12. Homeida AM, El Amin EA, Adam SE, Mahmoud MM, (1981) Toxicity of diminazene aceturate (Berenil) to camels. J Comp Pathol 91: 355-360.
13. Riou G, Benard J, (1980) Berenil induces the complete loss of kinetoblast DNA sequences in Trypanosoma equiperdum. Biochem Biophys Res Commun 96: 350-354.
14. Gonzalez VM, Perez JM, Alonso C, (1997) The berenil ligand directs the DNA binding of the cytotoxic drug Pt-berenil. J Inorg Biochem 68: 283-287.
15. Mahler HR, Perlman PS, (1973) Induction of respiration deficient mutants in Saccharomyces cerevisiae by berenil. I. Berenil, a novel, non-intercalating mutagen. Mol Gen Genet 121: 285-294.
16. Joubert KE, Kettner F, Lobetti RG, Miller DM, (2003) The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs. J S Afr Vet Assoc 74: 69-71.
17. Lumsden WH, Herbert WJ, Hardy GJ, (1965) In Vivo Prophylactic Activity of Berenil against Trypanosomes in Mice. Vet Rec 77: 147-148.
18. Uzonna JE, Kaushik RS, Gordon JR, Tabel H, (1999) Cytokines and antibody responses during Trypanosoma congolense infections in two inbred mouse strains that differ in resistance. Parasite Immunol 21: 57-71.
19. Rurangirwa FR, Tabel H, Losos GJ, Tizard IR, (1979) Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment. Infect Immun 26: 822-826.
20. Otesile EB, Tabel H, (1987) Enhanced resistance of highly susceptible Balb/c mice to infection with Trypanosoma congolense after infection and cure. J Parasitol 73: 947-953.
21. Tabel H, (1982) Activation of the alternative pathway of bovine complement by Trypanosoma congolense. Parasite Immunol 4: 329-335.
22. Lanham SM, Godfrey DG, (1970) Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose. Exp Parasitol 28: 521-534.
23. Wei G, Tabel H, (2008) Regulatory T cells prevent control of experimental African trypanosomiasis. J Immunol 180: 2514-2521.
24. Guilliams M, Oldenhove G, Noel W, Herin M, Brys L, et al. (2007) African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation. J Immunol 179: 2748-2757.
25. Okwor I, Onyilagha C, Kuriakose S, Mou Z, Jia P, et al. (2012) Regulatory T cells enhance susceptibility to experimental trypanosoma congolense infection independent of mouse genetic background. PLoS Negl Trop Dis 6: e1761.
26. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM, (1993) IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 151: 1224-1234.
27. Kaushik RS, Uzonna JE, Zhang Y, Gordon JR, Tabel H, (2000) Innate resistance to experimental African trypanosomiasis: differences in cytokine (TNF-alpha, IL-6, IL-10 and IL-12) production by bone marrow-derived macrophages from resistant and susceptible mice. Cytokine 12: 1024-1034.
28. Magez S, Radwanska M, Drennan M, Fick L, Baral TN, et al. (2006) Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis 193: 1575-1583.
29. Shi M, Pan W, Tabel H, (2003) Experimental African trypanosomiasis: IFN-gamma mediates early mortality. Eur J Immunol 33: 108-118.