Human Herpesvirus-6A/B Binds to Spermatozoa Acrosome and Is the Most Prevalent Herpesvirus in Semen from Sperm Donors

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Kaspersen, Maja D ^a   Larsen, Peter B ^b   Kofod Olsen, Emil ^a   Fedder, Jens ^c   Bonde, Jesper ^d   Höllsberg, Per ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Cryos International Sperm Bank   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

^d HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACROSOME; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FLOW CYTOMETRY; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HERPES VIRUS INFECTION; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN HERPESVIRUS 8; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; SPERM; SPERM DONOR; VARICELLA ZOSTER VIRUS; VIRUS ATTACHMENT; VIRUS DETECTION;

ACROSOME; HERPESVIRUS 6, HUMAN; HUMANS; MALE; ROSEOLOVIRUS INFECTIONS; SEMEN; TISSUE DONORS; VIRUS ATTACHMENT; VIRUS SHEDDING;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; HUMAN HERPESVIRUS 3; HUMAN HERPESVIRUS 4; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN HERPESVIRUS 8;

EID: 84868694163     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048810     Document Type: Article

References (22)

1. Naumenko VA, Tyulenev YA, Yakovenko SA, Kurilo LF, Shileyko LV, et al. (2011) Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture. Herpesviridae 2: 7.
2. Bezold G, Schuster-Grusser A, Lange M, Gall H, Wolff H, et al. (2001) Prevalence of human herpesvirus types 1-8 in the semen of infertility patients and correlation with semen parameters. Fertil Steril 76: 416-418.
3. Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, et al. (2007) Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 87: 1087-1097.
4. Thomas R, Macsween KF, McAulay K, Clutterbuck D, Anderson R, et al. (2006) Evidence of shared Epstein-Barr viral isolates between sexual partners, and low level EBV in genital secretions. J Med Virol 78: 1204-1209.
5. Mansat A, Mengelle C, Chalet M, Boumzebra A, Mieusset R, et al. (1997) Cytomegalovirus detection in cryopreserved semen samples collected for therapeutic donor insemination. Hum Reprod 12: 1663-1666.
6. McGowan MP, Hayes K, Kovacs GT, Leydon JA, (1983) Prevalence of cytomegalovirus and herpes simplex virus in human semen. Int J Androl 6: 331-336.
7. Diafouka F, Foulonge V, Hauhouot-Attoungbre M-L, Monnet D, Segondy M, (2007) Cytomegalovirus DNA in semen of men seeking fertility evaluation in Abidjan, Côte d'Ivoire. Eur J Clin Microbiol Infect Dis 26: 295-296.
8. Eggert-Kruse W, Reuland M, Johannsen W, Strowitzki T, Schlehofer JR, (2009) Cytomegalovirus (CMV) infection-related to male and/or female infertility factors? Fertil Steril 91: 67-82.
9. Levy R, Najioullah F, Keppi B, Thouvenot D, Bosshard S, et al. (1997) Detection of cytomegalovirus in semen from a population of men seeking infertility evaluation. Fertil Steril 68: 820-825.
10. Kapranos N, Petrakou E, Anastasiadou C, Kotronias D, (2003) Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic. Fertil Steril 79Suppl 3: 1566-1570.
11. Neofytou E, Sourvinos G, Asmarianaki M, Spandidos DA, Makrigiannakis A, (2009) Prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. Fertility and sterility 91: 2487-2494.
12. Michou V, Liarmakopoulou S, Thomas D, Tsimaratou K, Makarounis K, et al. (2012) Herpes virus infected spermatozoa following density gradient centrifugation for IVF purposes. Andrologia 44: 174-180.
13. Pallier C, Tebourbi L, Chopineau-Proust S, Schoevaert D, Nordmann P, Testart J, Courtot A, (2002) Herpesvirus, cytomegalovirus, human sperm and assisted fertilization. Human Reproduction 17: 1281-1287.
14. Bocharova EN, Abdumalikov RA, Bragina EE, Klimova RR, Adueva SM, et al. (2003) Determination of the proteins and capsids of herpes simplex virus in human spermatozoa. Dokl Biol Sci 391: 379-383.
15. Bocharova EN, Zavalishina LE, Bragina EE, Klimova RR, Gusak YK, et al. (2007) Detection of herpes simplex virus genomic DNA in spermatozoa of patients with fertility disorders by in situ hybridization. Dokl Biol Sci 412: 82-86.
16. Kaspersen MD, Larsen PB, Ingerslev HJ, Fedder J, Petersen GB, et al. (2011) Identification of multiple HPV types on spermatozoa from human sperm donors. PLoS One 6: e18095.
17. Oster B, Kaspersen MD, Kofod-Olsen E, Bundgaard B, Hollsberg P, (2006) Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway. J Clin Virol 37Suppl 1: S63-68.
18. Wang FZ, Pellett PE (2007) HHV-6A, 6B, and 7: immunobiology and host response. In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B et al., editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge.
19. The American Society for Reproductive Medicine (1998) Guidelines for gamete and embryo donation. Fertil Steril 70: 1S-13S.
20. Luppi M, Marasca R, Barozzi P, Ferrari S, Ceccherini-Nelli L, et al. (1993) Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 40: 44-52.
21. Leong HN, Tuke PW, Tedder RS, Khanom AB, Eglin RP, et al. (2007) The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. J Med Virol 79: 45-51.
22. Ando Y, Kakimoto K, Ekuni Y, Ichijo M, (1992) HHV-6 infection during pregnancy and spontaneous abortion. Lancet 340: 1289.