Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa

BMC Emergency Medicine

Volumn 12, Issue , 2012, Pages

  Mujuni, Erick ^a   Wangoda, Robert ^b   Ongom, Peter ^b   Galukande, Moses ^a  

^a MAKERERE UNIVERSITY   (Uganda)

^b MULAGO NATIONAL REFERRAL HOSPITAL   (Uganda)

Author keywords

Acute traumatic coagulopathy; Major trauma; PT PTT

Indexed keywords

ACUTE TRAUMATIC COAGULOPATHY; ADOLESCENT; ADULT; AFRICA; AGED; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CHILD; CONTROLLED STUDY; FEMALE; HOSPITALIZATION; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PRESCHOOL CHILD; PREVALENCE; PROTHROMBIN TIME; SCHOOL CHILD; TERTIARY HEALTH CARE; URBAN AREA; VENOUS BLOOD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOOD COAGULATION DISORDERS; CHILD; CHILD, PRESCHOOL; FEMALE; HEMORRHAGE; HOSPITAL MORTALITY; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTHROMBIN TIME; TERTIARY CARE CENTERS; UGANDA; WOUNDS, NONPENETRATING; WOUNDS, PENETRATING; YOUNG ADULT;

EID: 84868687087     PISSN: None     EISSN: 1471227X     Source Type: Journal    
DOI: 10.1186/1471-227X-12-16     Document Type: Article

References (25)

1. Krug EG, Sharma GK, Lozano R. The global burden of injuries. Am J Public Health 2000, 90:523-526. 1446200, 10754963.
2. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet 1997, 349:1269-1276. 10.1016/S0140-6736(96)07493-4, 9142060.
3. Hsia RY, Ozgediz D, Kobusingye OC. Epidemiology of injuries presenting to the national hospital in Kampala, Uganda: implications for research and policy. Int J Emergency medicine 2010, 3:165-172.
4. Jayaraman S, Ozgediz D, Miyamoto J, Mabweijano J. Disparities in injury mortality between Uganda and the united states: comparative analysis of a neglected disease. World J Surg 2011, 35:505-511. 10.1007/s00268-010-0871-z, 3032913, 21181159.
5. Idell S. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med 2003, 31(4 Suppl):S213-S220.
6. Brohi K, Singh J, Heron M, et al. Acute traumatic coagulopathy. J Trauma 2003, 54:1127-1130. 10.1097/01.TA.0000069184.82147.06, 12813333.
7. Brohi K, Cohen MJ, Ganter MT, et al. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?. Ann Surg 2007, 245:812-818. 10.1097/01.sla.0000256862.79374.31, 1877079, 17457176.
8. Kapsch DN, Metzler M, Harrington M, Mitchell FL, Silver D. Fibrinolytic response to trauma. Surgery 1984, 95:473-478.
9. Attar S, Boyd D, Layne E, McLaughlin J, Mansberger AR, Cowley RA. Alterations in coagulation and fibrinolytic mechanisms in acute trauma. J Trauma 1969, 9:939-965. 10.1097/00005373-196911000-00004, 5351798.
10. McNamara JJ, Burran EGL, Stremple JF, Molot MD. Coagulopathy after major combat injury: occurrence, management, and pathophysiology. Ann Surg 1972, 176:243-246. 10.1097/00000658-197208000-00021, 1355312, 5077085.
11. Macleod JBA, Lynn M, McKenney MG, et al. Early coagulopathy predicts mortality in trauma. J Trauma 2003, 55:39-44. 10.1097/01.TA.0000075338.21177.EF, 12855879.
12. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German trauma registry on 8724 patients. Injury 2007, 38:298-304. 10.1016/j.injury.2006.10.003, 17214989.
13. Schreiber MA. Damage control surgery. Crit Care Clin 2004, 20:101-118. 10.1016/S0749-0704(03)00095-2, 14979332.
14. Borgman M, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007, 63:805-813. 10.1097/TA.0b013e3181271ba3, 18090009.
15. Uganda Bureau of Statistics www.ubos.org, Uganda Bureau of Statistics.
16. Lemeshow S, Hosmer DW, Klar J, Lwanga SK. Adequacy of Sample Size in Health Studies 1990, World Health Organization, Wiley, New York: NY.
17. Hulley S, Cummings S, Browner W, Glady D, Hearst N, Newman T. Designing clinical research an epidemiologic approach. Chapter 6 estimating sample and power 2001, Lippincott Williams and Wilkins, Hagerstown, Maryland, 2.
18. Enderson BL, Chen JP, Robinson R, Maull KI. Fibrinolysis in multisystem trauma patients. J Trauma 1991, 31:1240-1246. 10.1097/00005373-199109000-00007, 1920554.
19. Gando S, Tedo I, Kubota M. Post trauma coagulation and fibrinolysis. Crit Care Med 1992, 20:594-600. 10.1097/00003246-199205000-00009, 1533358.
20. Cortiana M, Zagara G, Fava S, Seveso M. Coagulation abnormalities in patients with head injury. J Neurosurg Sci 1986, 30:133-138.
21. Hulka F, Mullins RJ, Frank EH. Blunt brain injury activates the coagulation process. Arch Surg 1996, 131:923-928. 10.1001/archsurg.1996.01430210021004, 8790176.
22. Preston FE, Malia RG, Sworn MJ, Timperley WR, Blackburn EK. Disseminated intravascular coagulation as a consequence of cerebral damage. J Neurol Neurosurg Psychiatry 1974, 37:241-248. 10.1136/jnnp.37.3.241, 494635, 4829528.
23. Ggayi M. Systemic inflammatory response syndrome score of trauma patients at admission as predictor of mortality and length of stay in mulago hospital 2005, Makerere University, A dissertation of Masters of Medicine in Surgery.
24. Odubu FL. Patterns of multiple trauma at new mulago hospital 1996, Makerere University, A dissertation of Masters of Medicine in surgery.
25. Kirya FM, Kijjambu S, Ezati I. Outcome of major trauma at mulago hospital in Uganda. Assessment using the TRISS methodology. East and Central African Journal of Surgery 2002, 7(1):59-62.