메뉴 건너뛰기




Volumn 32, Issue 19, 2012, Pages 4001-4011

The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B BETA; SUBSTRATE S6 KINASE 1; UNCLASSIFIED DRUG;

EID: 84868685585     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00514-12     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 34249697628 scopus 로고    scopus 로고
    • S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase
    • Aguilar V, et al. 2007. S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab. 5:476-487.
    • (2007) Cell Metab , vol.5 , pp. 476-487
    • Aguilar, V.1
  • 2
    • 55849111942 scopus 로고    scopus 로고
    • Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation
    • Alliouachene S, et al. 2008. Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation. J. Clin. Invest. 118:3629 -3638.
    • (2008) J. Clin. Invest , vol.118 , pp. 3629-3638
    • Alliouachene, S.1
  • 3
    • 77956534963 scopus 로고    scopus 로고
    • Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    • Ayala JE, et al. 2010. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis. Model. Mech. 3:525-534.
    • (2010) Dis. Model. Mech , vol.3 , pp. 525-534
    • Ayala, J.E.1
  • 4
    • 77952893054 scopus 로고    scopus 로고
    • S6K1 plays a critical role in early adipocyte differentiation
    • Carnevalli LS, et al. 2010. S6K1 plays a critical role in early adipocyte differentiation. Dev. Cell 18:763-774.
    • (2010) Dev. Cell , vol.18 , pp. 763-774
    • Carnevalli, L.S.1
  • 5
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    • Cho H, et al. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292: 1728-1731.
    • (2001) Science , vol.292 , pp. 1728-1731
    • Cho, H.1
  • 6
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156 -159.
    • (1987) Anal. Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 7
    • 38949140180 scopus 로고    scopus 로고
    • Dual role of proapoptotic BAD in insulin secretion and beta cell survival
    • Danial NN, et al. 2008. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat. Med. 14:144 -153.
    • (2008) Nat. Med , vol.14 , pp. 144-153
    • Danial, N.N.1
  • 8
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • Dibble CC, Asara JM, Manning BD. 2009. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol. Cell. Biol. 29:5657-5670.
    • (2009) Mol. Cell. Biol , vol.29 , pp. 5657-5670
    • Dibble, C.C.1    Asara, J.M.2    Manning, B.D.3
  • 9
    • 79959957224 scopus 로고    scopus 로고
    • S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
    • Espeillac C, et al. 2011. S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy. J. Clin. Invest. 121:2821- 2832.
    • (2011) J. Clin. Invest , vol.121 , pp. 2821-2832
    • Espeillac, C.1
  • 10
    • 42449104351 scopus 로고    scopus 로고
    • mTOR inhibition by rapamycin prevents betacell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • Fraenkel M, et al. 2008. mTOR inhibition by rapamycin prevents betacell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57:945-957.
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1
  • 11
    • 0035859956 scopus 로고    scopus 로고
    • p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
    • Harada H, Andersen JS, Mann M, Terada N, Korsmeyer SJ. 2001. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc. Natl. Acad. Sci. U. S. A. 98:9666 -9670.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 9666-9670
    • Harada, H.1    Andersen, J.S.2    Mann, M.3    Terada, N.4    Korsmeyer, S.J.5
  • 12
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington LS, et al. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166:213-223.
    • (2004) J. Cell Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1
  • 13
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, et al. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1
  • 14
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz MK, Blenis J. 2005. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280:26089 -26093.
    • (2005) J. Biol. Chem , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 15
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • Houde VP, et al. 2010. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59:1338 -1348.
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1
  • 16
    • 75749105049 scopus 로고    scopus 로고
    • mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • Julien LA, Carriere A, Moreau J, Roux PP. 2010. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol. Cell. Biol. 30:908 -921.
    • (2010) Mol. Cell. Biol , vol.30 , pp. 908-921
    • Julien, L.A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 17
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming DW, et al. 2012. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335: 1638-1643.
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1
  • 19
    • 84857934301 scopus 로고    scopus 로고
    • Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
    • Lu M, et al. 2012. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat. Med. 18:388 -395.
    • (2012) Nat. Med , vol.18 , pp. 388-395
    • Lu, M.1
  • 20
    • 79959635928 scopus 로고    scopus 로고
    • Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase
    • Lustig Y, et al. 2011. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev. 25:1232-1244.
    • (2011) Genes Dev , vol.25 , pp. 1232-1244
    • Lustig, Y.1
  • 21
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning BD, Cantley LC. 2007. AKT/PKB signaling: navigating downstream. Cell 129:1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 22
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, et al. 2000. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6:87-97.
    • (2000) Mol. Cell , vol.6 , pp. 87-97
    • Michael, M.D.1
  • 23
    • 20044392290 scopus 로고    scopus 로고
    • Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
    • Ohanna M, et al. 2005. Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat. Cell Biol. 7:286 -294.
    • (2005) Nat. Cell Biol , vol.7 , pp. 286-294
    • Ohanna, M.1
  • 24
    • 33846418352 scopus 로고    scopus 로고
    • Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
    • Pan KZ, et al. 2007. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6:111-119.
    • (2007) Aging Cell , vol.6 , pp. 111-119
    • Pan, K.Z.1
  • 25
    • 84857694058 scopus 로고    scopus 로고
    • PPARgamma contributes to PKM2 and HK2 expression in fatty liver
    • Panasyuk G, et al. 2012. PPARgamma contributes to PKM2 and HK2 expression in fatty liver. Nat. Commun. 3:672.
    • (2012) Nat. Commun , vol.3 , pp. 672
    • Panasyuk, G.1
  • 26
    • 0034700456 scopus 로고    scopus 로고
    • Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
    • Pende M, et al. 2000. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 408:994 -997.
    • (2000) Nature , vol.408 , pp. 994-997
    • Pende, M.1
  • 27
    • 33846580517 scopus 로고    scopus 로고
    • Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
    • Reznick RM, et al. 2007. Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab. 5:151- 156.
    • (2007) Cell Metab , vol.5 , pp. 151-156
    • Reznick, R.M.1
  • 28
    • 24944464482 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
    • Ruvinsky I, et al. 2005. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 19:2199 -2211.
    • (2005) Genes Dev , vol.19 , pp. 2199-2211
    • Ruvinsky, I.1
  • 29
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 30
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, et al. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22:159 -168.
    • (2006) Mol. Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1
  • 31
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    • Selman C, et al. 2009. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326:140 -144.
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1
  • 32
    • 33747808579 scopus 로고    scopus 로고
    • Turnover of the active fraction of IRS1 involves raptor-mTOR-and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
    • Shah OJ, Hunter T. 2006. Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol. Cell. Biol. 26:6425- 6434.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 6425-6434
    • Shah, O.J.1    Hunter, T.2
  • 33
    • 0032538890 scopus 로고    scopus 로고
    • Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
    • Shima H, et al. 1998. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17: 6649-6659.
    • (1998) EMBO J , vol.17 , pp. 6649-6659
    • Shima, H.1
  • 34
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. 2006. Critical nodes in signalling pathways: insights into insulin action. Nat. Rev. Mol. Cell Biol. 7:85-96.
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 36
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age-and dietinduced obesity while enhancing insulin sensitivity
    • Um SH, et al. 2004. Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity. Nature 431:200 -205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1
  • 37
    • 67949084959 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and diabetes: what does the current evidence tell us?
    • Vodenik B, Rovira J, Campistol JM. 2009. Mammalian target of rapamycin and diabetes: what does the current evidence tell us? Transplant. Proc. 41:S31-S38.
    • (2009) Transplant Proc , vol.41
    • Vodenik, B.1    Rovira, J.2    Campistol, J.M.3
  • 38
    • 84862536825 scopus 로고    scopus 로고
    • Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
    • Yang SB, et al. 2011. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J. Mol. Med. (Berl). 90:575-585.
    • (2011) J. Mol. Med. (Berl) , vol.90 , pp. 575-585
    • Yang, S.B.1
  • 39
    • 0038686576 scopus 로고    scopus 로고
    • Suppression of beta cell energy metabolism and insulin release by PGC-1alpha
    • Yoon JC, et al. 2003. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev. Cell 5:73- 83.
    • (2003) Dev. Cell , vol.5 , pp. 73-83
    • Yoon, J.C.1
  • 40
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. 2011. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12:21-35.
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.