HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8

Molecular and Cellular Biology

Volumn 32, Issue 21, 2012, Pages 4482-4492

  Kim, Goo Young ^a   Kim, Ho Young ^a   Kim, Hyun Taek ^b   Moon, Jeong Mi ^a   Kim, Cheol Hee ^b   Kang, Seongman ^c   Rhim, Hyangshuk ^a  

^a The Catholic University of Korea   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 8; HIGH TEMPERATURE REQUIREMENT A1; MESSENGER RNA; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO; EMBRYO DEVELOPMENT; FIBROBLAST GROWTH FACTOR 8 GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ZEBRA FISH;

ANIMALS; BODY PATTERNING; FIBROBLAST GROWTH FACTOR 8; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MORPHOLINOS; PHENOTYPE; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 84868682994     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00872-12     Document Type: Article

References (48)

1. Baldi A, et al. 2002. The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene 21:6684-6688.
2. Beenken A, Mohammadi M. 2009. The FGF family: biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 8:235-253.
3. Bottcher RT, Niehrs C. 2005. Fibroblast growth factor signaling during early vertebrate development. Endocr Rev. 26:63-77.
4. Bottcher RT, Pollet N, Delius H, Niehrs C. 2004. The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Nat. Cell Biol. 6:38-44.
5. Chamberland A, et al. 2009. Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. J. Biol. Chem. 284:27352-27359.
6. Chien J, et al. 2006. Serine protease HtrA1 modulates chemotherapyinduced cytotoxicity. J. Clin. Invest. 116:1994 -2004.
7. Chien J, et al. 2009. Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol. Cell. Biol. 29:4177- 4187.
8. Clausen T, Kaiser M, Huber R, Ehrmann M. 2011. HTRA proteases: regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol. 12:152-162.
9. Clausen T, Southan C, Ehrmann M. 2002. The HtrA family of proteases: implications for protein composition and cell fate. Mol. Cell 10:443- 455.
10. Crossley PH, Minowada G, MacArthur CA, Martin GR. 1996. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84:127-136.
11. Dewan A, et al. 2006. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science 314:989 -992.
12. Ferrer-Vaquer A, et al. 2008. Expression and regulation of HTRA1 during chick and early mouse development. Dev. Dyn. 237:1893-1900.
13. Fox JC, Swain JL. 1993. Auto and transactivation of FGF expression: potential mechanism for regulation of myogenic differentiation. In Vitro Cell Dev. Biol. 29A:228 -230.
14. Friedrich U, et al. 2011. Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency. Hum. Mol. Genet. 20:1387- 1399.
15. Furthauer M, Lin W, Ang SL, Thisse B, Thisse C. 2002. Sef is a feedbackinduced antagonist of Ras/MAPK-mediated FGF signalling. Nat. Cell Biol. 4:170 -174.
16. Furthauer M, Thisse C, Thisse B. 1997. A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development 124:4253- 4264.
17. Furthauer M, Van Celst J, Thisse C, Thisse B. 2004. Fgf signalling controls the dorsoventral patterning of the zebrafish embryo. Development 131:2853-2864.
18. Grau S, et al. 2005. Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc. Natl. Acad. Sci. U. S. A. 102:6021- 6026.
19. Grau S, et al. 2006. The role of human HtrA1 in arthritic disease. J. Biol. Chem. 281:6124-6129.
20. Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA. 1998. sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92:253-263.
21. Hadfield KD, et al. 2008. HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains. J. Biol. Chem. 283:5928 -5938.
22. Hara K, et al. 2009. Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. N. Engl. J. Med. 360:1729 -1739.
23. He X, et al. 2010. Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. Cancer Res. 70:3109 -3118.
24. Hou J, Clemmons DR, Smeekens S. 2005. Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5. J. Cell Biochem. 94:470-484.
25. Hou S, Maccarana M, Min TH, Strate I, Pera EM. 2007. The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo. Dev. Cell 13:226 -241.
26. Hu SI, et al. 1998. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. J. Biol. Chem. 273:34406 -34412.
27. Jones A, et al. 2011. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc. Natl. Acad. Sci. U. S. A. 108:14578 -14583.
28. Kawakami Y, et al. 2003. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat. Cell Biol. 5:513-519.
29. Kim GY, Moon JM, Han JH, Kim KH, Rhim H. 2011. The sCMV IE enhancer/promoter system for high-level expression and efficient functional studies of target genes in mammalian cells and zebrafish. Biotechnol. Lett. 33:1319 -1326.
30. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. 1995. Stages of embryonic development of the zebrafish. Dev. Dyn. 203:253- 310.
31. Launay S, et al. 2008. HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival. Cell Death Differ. 15:1408 -1416.
32. Mohammadi M, et al. 1997. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-960.
33. Mullins MC, et al. 1996. Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development 123:81-93.
34. Nissen NN, Shankar R, Gamelli RL, Singh A, DiPietro LA. 1999. Heparin and heparan sulphate protect basic fibroblast growth factor from non-enzymic glycosylation. Biochem. J. 338:637- 642.
35. Nowak M, Machate A, Yu SR, Gupta M, Brand M. 2011. Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking. Nat. Cell Biol. 13:153-158.
36. Nüsslein-Volhard C, Dahm R. 2002. Zebrafish: a practical approach. Oxford University Press, Oxford, United Kingdom.
37. Oka C, et al. 2004. HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development 131:1041-1053.
38. Schier AF. 2007. The maternal-zygotic transition: death and birth of RNAs. Science 316:406-407.
39. Scholpp S, Brand M. 2004. Endocytosis controls spreading and effective signaling range of Fgf8 protein. Curr. Biol. 14:1834 -1841.
40. Seong YM, et al. 2004. Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP. J. Biol. Chem. 279:37588 -37596.
41. Shiga A, et al. 2011. Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-1. Hum. Mol. Genet. 20:1800 -1810.
42. Tsang M, Dawid IB. 2004. Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci. STKE 2004:pe17. doi:10.1126/stke.2282004pe17.
43. Turner N, Grose R. 2010. Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 10:116 -129.
44. Wang Q, Uhlirova M, Bohmann D. 2010. Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis. Dev. Cell 18:157-164.
45. Wittkopp N, et al. 2009. Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol. Cell. Biol. 29:3517-3528.
46. Yang Z, et al. 2006. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 314:992-993.
47. Yu SR, et al. 2009. Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature 461:533-536.
48. Zhang L, et al. 2012. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6. J. Biol. Chem. 287:1520- 1526.