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Volumn 934, Issue , 2012, Pages 193-218

Aging microglia: Relevance to cognition and neural plasticity

Author keywords

Aged; Cytokine; Exercise; Learning; Long term potentiation; Memory; Microglia; Neurogenesis; Neuroinflammation; Nutrition

Indexed keywords

AGING; ANIMAL; ARTICLE; CALORIC RESTRICTION; COGNITION; CYTOLOGY; EXERCISE; HIPPOCAMPUS; HUMAN; IMMUNOLOGY; INFLAMMATION; MICROGLIA; NERVE CELL PLASTICITY; PATHOLOGY; PHYSIOLOGY;

EID: 84868682201     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-071-7_11     Document Type: Article
Times cited : (19)

References (148)
  • 1
    • 11844254511 scopus 로고    scopus 로고
    • Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury
    • Basu A, Lazovic J, Krady JK, Mauger DT, Rothstein RP, Smith MB et al (2005) Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab 25:17-29
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 17-29
    • Basu, A.1    Lazovic, J.2    Krady, J.K.3    Mauger, D.T.4    Rothstein, R.P.5    Smith, M.B.6
  • 2
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 3
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/ microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • Benveniste EN (1997) Role of macrophages/ microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med (Berl) 75:165-173
    • (1997) J Mol Med (Berl) , vol.75 , pp. 165-173
    • Benveniste, E.N.1
  • 4
    • 61449224570 scopus 로고    scopus 로고
    • Microglia: Gatekeepers of central nervous system immunology
    • Tambuyzer BR, Ponsaerts P, Nouwen EJ (2009) Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 85: 352-370
    • (2009) J Leukoc Biol , vol.85 , pp. 352-370
    • Tambuyzer, B.R.1    Ponsaerts, P.2    Nouwen, E.J.3
  • 6
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 7
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev ED, Maresz K, Tan Y, Dittel BN (2007) CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci 27:10714-10721
    • (2007) J Neurosci , vol.27 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 8
    • 30344480502 scopus 로고    scopus 로고
    • Microglial morphology and its transformation after challenge by extracellular ATP in vitro
    • Xiang Z, Chen M, Ping J, Dunn P, Lv J, Jiao B et al (2006) Microglial morphology and its transformation after challenge by extracellular ATP in vitro. J Neurosci Res 83:91-101
    • (2006) J Neurosci Res , vol.83 , pp. 91-101
    • Xiang, Z.1    Chen, M.2    Ping, J.3    Dunn, P.4    Lv, J.5    Jiao, B.6
  • 9
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F (2001) Immune function of microglia. Glia 36:165-179
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 10
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • Dilger RN, Johnson RW (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84:932-939
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 12
    • 0029068714 scopus 로고
    • Microglial turnover in the injured CNS: Activated microglia undergo delayed DNA fragmentation following peripheral nerve injury
    • Gehrmann J, Banati RB (1995) Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 54:680-688
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 680-688
    • Gehrmann, J.1    Banati, R.B.2
  • 13
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4:399-418
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 14
    • 0034237666 scopus 로고    scopus 로고
    • Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures
    • Kitamura Y, Taniguchi T, Kimura H, Nomura Y, Gebicke-Haerter PJ (2000) Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures. J Neuroimmunol 106:95-104
    • (2000) J Neuroimmunol , vol.106 , pp. 95-104
    • Kitamura, Y.1    Taniguchi, T.2    Kimura, H.3    Nomura, Y.4    Gebicke-Haerter, P.J.5
  • 15
    • 20444364844 scopus 로고    scopus 로고
    • Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective
    • Butovsky O, Talpalar AE, Ben-Yaakov K, Schwartz M (2005) Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol Cell Neurosci 29:381-393
    • (2005) Mol Cell Neurosci , vol.29 , pp. 381-393
    • Butovsky, O.1    Talpalar, A.E.2    Ben-Yaakov, K.3    Schwartz, M.4
  • 18
    • 0035907263 scopus 로고    scopus 로고
    • A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin
    • Chang NC, Hung SI, Hwa KY, Kato I, Chen JE, Liu CH et al (2001) A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem 276:17497-17506
    • (2001) J Biol Chem , vol.276 , pp. 17497-17506
    • Chang, N.C.1    Hung, S.I.2    Hwa, K.Y.3    Kato, I.4    Chen, J.E.5    Liu, C.H.6
  • 19
    • 0031809194 scopus 로고    scopus 로고
    • Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion
    • Brodie C, Goldreich N, Haiman T, Kazimirsky G (1998) Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion. J Neuroimmunol 81:20-30
    • (1998) J Neuroimmunol , vol.81 , pp. 20-30
    • Brodie, C.1    Goldreich, N.2    Haiman, T.3    Kazimirsky, G.4
  • 20
    • 0036321329 scopus 로고    scopus 로고
    • Ceramide activates microglia to enhance the production/secretion of brainderived neurotrophic factor (BDNF) without induction of deleterious factors in vitro
    • Nakajima K, Tohyama Y, Kohsaka S, Kurihara T (2002) Ceramide activates microglia to enhance the production/secretion of brainderived neurotrophic factor (BDNF) without induction of deleterious factors in vitro. J Neurochem 80:697-705
    • (2002) J Neurochem , vol.80 , pp. 697-705
    • Nakajima, K.1    Tohyama, Y.2    Kohsaka, S.3    Kurihara, T.4
  • 21
    • 33746827434 scopus 로고    scopus 로고
    • Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
    • Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H et al (2006) Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A 103:11784-11789
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11784-11789
    • Butovsky, O.1    Koronyo-Hamaoui, M.2    Kunis, G.3    Ophir, E.4    Landa, G.5    Cohen, H.6
  • 22
    • 58149216131 scopus 로고    scopus 로고
    • Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: Agedependent switch in the microglial phenotype from alternative to classic
    • Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R et al (2008) Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: agedependent switch in the microglial phenotype from alternative to classic. J Neurosci 28:11650-11661
    • (2008) J Neurosci , vol.28 , pp. 11650-11661
    • Jimenez, S.1    Baglietto-Vargas, D.2    Caballero, C.3    Moreno-Gonzalez, I.4    Torres, M.5    Sanchez-Varo, R.6
  • 23
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K (2007) Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55:412-424
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 25
    • 34447549299 scopus 로고    scopus 로고
    • Interleukin-1beta and caspase-1: Players in the regulation of age-related cognitive dysfunction
    • Gemma C, Bickford PC (2007) Interleukin-1beta and caspase-1: players in the regulation of age-related cognitive dysfunction. Rev Neurosci 18:137-148
    • (2007) Rev Neurosci , vol.18 , pp. 137-148
    • Gemma, C.1    Bickford, P.C.2
  • 26
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • Perry VH, Matyszak MK, Fearn S (1993) Altered antigen expression of microglia in the aged rodent CNS. Glia 7:60-67
    • (1993) Glia , vol.7 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 27
    • 0030967157 scopus 로고    scopus 로고
    • Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits
    • Streit WJ, Sparks DL (1997) Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits. J Mol Med 75:130-138
    • (1997) J Mol Med , vol.75 , pp. 130-138
    • Streit, W.J.1    Sparks, D.L.2
  • 28
    • 0031960498 scopus 로고    scopus 로고
    • Microglial expression of MHC class II increases in normal aging of nonhuman primates
    • Sheffield LG, Berman NE (1998) Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol Aging 19:47-55
    • (1998) Neurobiol Aging , vol.19 , pp. 47-55
    • Sheffield, L.G.1    Berman, N.E.2
  • 29
    • 0032806355 scopus 로고    scopus 로고
    • Increased microglial activation and protein nitration in white matter of the aging monkey
    • Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR (1999) Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 20:395-405
    • (1999) Neurobiol Aging , vol.20 , pp. 395-405
    • Sloane, J.A.1    Hollander, W.2    Moss, M.B.3    Rosene, D.L.4    Abraham, C.R.5
  • 30
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW et al (2005) Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 19:1329-1331
    • (2005) FASEB J , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6
  • 31
    • 0032916578 scopus 로고    scopus 로고
    • Increased interleukin-6 expression by microglia from brain of aged mice
    • Ye SM, Johnson RW (1999) Increased interleukin-6 expression by microglia from brain of aged mice. J Neuroimmunol 93:139-148
    • (1999) J Neuroimmunol , vol.93 , pp. 139-148
    • Ye, S.M.1    Johnson, R.W.2
  • 33
    • 0035957802 scopus 로고    scopus 로고
    • Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord
    • Kullberg S, Aldskogius H, Ulfhake B (2001) Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord. Brain Res 899:169-186
    • (2001) Brain Res , vol.899 , pp. 169-186
    • Kullberg, S.1    Aldskogius, H.2    Ulfhake, B.3
  • 35
    • 0031960552 scopus 로고    scopus 로고
    • Age-related activation of microglia and astrocytes: In vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation
    • Rozovsky I, Finch CE, Morgan TE (1998) Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation. Neurobiol Aging 19:97-103
    • (1998) Neurobiol Aging , vol.19 , pp. 97-103
    • Rozovsky, I.1    Finch, C.E.2    Morgan, T.E.3
  • 36
    • 34250171784 scopus 로고    scopus 로고
    • Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma
    • Inman DM, Horner PJ (2007) Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia 55:942-953
    • (2007) Glia , vol.55 , pp. 942-953
    • Inman, D.M.1    Horner, P.J.2
  • 37
    • 33747778349 scopus 로고    scopus 로고
    • Effect of aging on the microglial response to peripheral nerve injury
    • Conde JR, Streit WJ (2006) Effect of aging on the microglial response to peripheral nerve injury. Neurobiol Aging 27:1451-1461
    • (2006) Neurobiol Aging , vol.27 , pp. 1451-1461
    • Conde, J.R.1    Streit, W.J.2
  • 38
    • 84861986137 scopus 로고    scopus 로고
    • Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
    • Kohman RA, DeYoung EK, Bhattacharya TK, Peterson LN, Rhodes JS (2012) Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice. Brain Behav Immun 26:803-810
    • (2012) Brain Behav Immun , vol.26 , pp. 803-810
    • Kohman, R.A.1    Deyoung, E.K.2    Bhattacharya, T.K.3    Peterson, L.N.4    Rhodes, J.S.5
  • 40
  • 41
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
    • Vaughan DW, Peters A (1974) Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol 3:405-429
    • (1974) J Neurocytol , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2
  • 42
    • 0036133121 scopus 로고    scopus 로고
    • The effects of age on the cells in layer 1 of primate cerebral cortex
    • Peters A, Sethares C (2002) The effects of age on the cells in layer 1 of primate cerebral cortex. Cereb Cortex 12:27-36
    • (2002) Cereb Cortex , vol.12 , pp. 27-36
    • Peters, A.1    Sethares, C.2
  • 43
    • 0026025918 scopus 로고
    • Effects of aging on the neuroglial cells and pericytes within area 17 of the rhesus monkey cerebral cortex
    • Peters A, Josephson K, Vincent SL (1991) Effects of aging on the neuroglial cells and pericytes within area 17 of the rhesus monkey cerebral cortex. Anat Rec 229:384-398
    • (1991) Anat Rec , vol.229 , pp. 384-398
    • Peters, A.1    Josephson, K.2    Vincent, S.L.3
  • 44
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005) Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci 25:9275-9284
    • (2005) J Neurosci , vol.25 , pp. 9275-9284
    • Cunningham, C.1    Wilcockson, D.C.2    Campion, S.3    Lunnon, K.4    Perry, V.H.5
  • 45
    • 0034458454 scopus 로고    scopus 로고
    • The cerebral proteopathies: Neurodegenerative disorders of protein conformation and assembly
    • Walker LC, LeVine H (2000) The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly. Mol Neurobiol 21:83-95
    • (2000) Mol Neurobiol , vol.21 , pp. 83-95
    • Walker, L.C.1    Levine, H.2
  • 47
    • 0036841128 scopus 로고    scopus 로고
    • Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis
    • Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD (2002) Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 161: 1669-1677
    • (2002) Am J Pathol , vol.161 , pp. 1669-1677
    • Broderick, C.1    Hoek, R.M.2    Forrester, J.V.3    Liversidge, J.4    Sedgwick, J.D.5    Dick, A.D.6
  • 48
    • 17744388105 scopus 로고    scopus 로고
    • Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    • Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM et al (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290:1768-1771
    • (2000) Science , vol.290 , pp. 1768-1771
    • Hoek, R.M.1    Ruuls, S.R.2    Murphy, C.A.3    Wright, G.J.4    Goddard, R.5    Zurawski, S.M.6
  • 49
    • 33646871748 scopus 로고    scopus 로고
    • Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction
    • Deckert M, Sedgwick JD, Fischer E, Schluter D (2006) Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction. Acta Neuropathol 111:548-558
    • (2006) Acta Neuropathol , vol.111 , pp. 548-558
    • Deckert, M.1    Sedgwick, J.D.2    Fischer, E.3    Schluter, D.4
  • 50
    • 78650994912 scopus 로고    scopus 로고
    • Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
    • Wynne AM, Henry CJ, Huang Y, Cleland A, Godbout JP (2010) Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav Immun 24:1190-1201
    • (2010) Brain Behav Immun , vol.24 , pp. 1190-1201
    • Wynne, A.M.1    Henry, C.J.2    Huang, Y.3    Cleland, A.4    Godbout, J.P.5
  • 51
    • 13144279282 scopus 로고    scopus 로고
    • Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia
    • Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara RK et al (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A 95:10896-10901
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 10896-10901
    • Harrison, J.K.1    Jiang, Y.2    Chen, S.3    Xia, Y.4    MacIejewski, D.5    McNamara, R.K.6
  • 53
    • 68949200462 scopus 로고    scopus 로고
    • Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro
    • Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A et al (2009) Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro. J Neurochem 110:1547-1556
    • (2009) J Neurochem , vol.110 , pp. 1547-1556
    • Lyons, A.1    Lynch, A.M.2    Downer, E.J.3    Hanley, R.4    O'Sullivan, J.B.5    Smith, A.6
  • 54
    • 33644788171 scopus 로고    scopus 로고
    • Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation
    • Maher FO, Clarke RM, Kelly A, Nally RE, Lynch MA (2006) Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation. J Neurochem 96:1560-1571
    • (2006) J Neurochem , vol.96 , pp. 1560-1571
    • Maher, F.O.1    Clarke, R.M.2    Kelly, A.3    Nally, R.E.4    Lynch, M.A.5
  • 55
    • 13644253039 scopus 로고    scopus 로고
    • Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat
    • Maher FO, Nolan Y, Lynch MA (2005) Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiol Aging 26: 717-728
    • (2005) Neurobiol Aging , vol.26 , pp. 717-728
    • Maher, F.O.1    Nolan, Y.2    Lynch, M.A.3
  • 56
    • 0024159821 scopus 로고
    • Biological basis of the behavior of sick animals
    • Hart BL (1988) Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 12:123-137
    • (1988) Neurosci Biobehav Rev , vol.12 , pp. 123-137
    • Hart, B.L.1
  • 59
    • 0035038172 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior: Mechanisms and implications
    • Dantzer R (2001) Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 933:222-234
    • (2001) Ann N y Acad Sci , vol.933 , pp. 222-234
    • Dantzer, R.1
  • 60
    • 20544463202 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide administration impairs two-way active avoidance conditioning in C57BL/6J mice
    • Sparkman NL, Kohman RA, Garcia AK, Boehm GW (2005) Peripheral lipopolysaccharide administration impairs two-way active avoidance conditioning in C57BL/6J mice. Physiol Behav 85:278-288
    • (2005) Physiol Behav , vol.85 , pp. 278-288
    • Sparkman, N.L.1    Kohman, R.A.2    Garcia, A.K.3    Boehm, G.W.4
  • 61
    • 34347221903 scopus 로고    scopus 로고
    • Alleviation of the effects of endotoxin exposure on behavior and hippocampal IL-1beta by a selective non-peptide antagonist of corticotropin-releasing factor receptors
    • Kohman RA, Tarr AJ, Sparkman NL, Day CE, Paquet A, Akkaraju GR et al (2007) Alleviation of the effects of endotoxin exposure on behavior and hippocampal IL-1beta by a selective non-peptide antagonist of corticotropin-releasing factor receptors. Brain Behav Immun 21:824-835
    • (2007) Brain Behav Immun , vol.21 , pp. 824-835
    • Kohman, R.A.1    Tarr, A.J.2    Sparkman, N.L.3    Day, C.E.4    Paquet, A.5    Akkaraju, G.R.6
  • 62
    • 24944568523 scopus 로고    scopus 로고
    • Bacterial endotoxininduced behavioral alterations in two variations of the Morris water maze
    • Sparkman NL, Kohman RA, Scott VJ, Boehm GW (2005) Bacterial endotoxininduced behavioral alterations in two variations of the Morris water maze. Physiol Behav 86: 244-251
    • (2005) Physiol Behav , vol.86 , pp. 244-251
    • Sparkman, N.L.1    Kohman, R.A.2    Scott, V.J.3    Boehm, G.W.4
  • 63
    • 0031773020 scopus 로고    scopus 로고
    • Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning
    • Pugh CR, Kumagawa K, Fleshner M, Watkins LR, Maier SF, Rudy JW (1998) Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav Immun 12: 212-229
    • (1998) Brain Behav Immun , vol.12 , pp. 212-229
    • Pugh, C.R.1    Kumagawa, K.2    Fleshner, M.3    Watkins, L.R.4    Maier, S.F.5    Rudy, J.W.6
  • 64
    • 24044436865 scopus 로고    scopus 로고
    • Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation
    • Thomson LM, Sutherland RJ (2005) Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation. Brain Res Bull 67:24-29
    • (2005) Brain Res Bull , vol.67 , pp. 24-29
    • Thomson, L.M.1    Sutherland, R.J.2
  • 66
    • 78149406326 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans
    • Grigoleit JS, Oberbeck JR, Lichte P, Kobbe P, Wolf OT, Montag T et al (2010) Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans. Neurobiol Learn Mem 94:561-567
    • (2010) Neurobiol Learn Mem , vol.94 , pp. 561-567
    • Grigoleit, J.S.1    Oberbeck, J.R.2    Lichte, P.3    Kobbe, P.4    Wolf, O.T.5    Montag, T.6
  • 67
    • 0034990845 scopus 로고    scopus 로고
    • Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus
    • Shaw KN, Commins S, O'Mara SM (2001) Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus. Behav Brain Res 124:47-54
    • (2001) Behav Brain Res , vol.124 , pp. 47-54
    • Shaw, K.N.1    Commins, S.2    O'Mara, S.M.3
  • 68
    • 0035210655 scopus 로고    scopus 로고
    • Deterioration of spatial learning performances in lipopolysaccharide- treated mice
    • Arai K, Matsuki N, Ikegaya Y, Nishiyama N (2001) Deterioration of spatial learning performances in lipopolysaccharide-treated mice. Jpn J Pharmacol 87:195-201
    • (2001) Jpn J Pharmacol , vol.87 , pp. 195-201
    • Arai, K.1    Matsuki, N.2    Ikegaya, Y.3    Nishiyama, N.4
  • 69
    • 0029079890 scopus 로고
    • Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat
    • Aubert A, Vega C, Dantzer R, Goodall G (1995) Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat. Brain Behav Immun 9:129-148
    • (1995) Brain Behav Immun , vol.9 , pp. 129-148
    • Aubert, A.1    Vega, C.2    Dantzer, R.3    Goodall, G.4
  • 70
    • 0037151285 scopus 로고    scopus 로고
    • Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus
    • Barrientos RM, Higgins EA, Sprunger DB, Watkins LR, Rudy JW, Maier SF (2002) Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus. Behav Brain Res 134:291-298
    • (2002) Behav Brain Res , vol.134 , pp. 291-298
    • Barrientos, R.M.1    Higgins, E.A.2    Sprunger, D.B.3    Watkins, L.R.4    Rudy, J.W.5    Maier, S.F.6
  • 73
    • 0142172107 scopus 로고    scopus 로고
    • Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
    • Avital A, Goshen I, Kamsler A, Segal M, Iverfeldt K, Richter-Levin G et al (2003) Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 13: 826-834
    • (2003) Hippocampus , vol.13 , pp. 826-834
    • Avital, A.1    Goshen, I.2    Kamsler, A.3    Segal, M.4    Iverfeldt, K.5    Richter-Levin, G.6
  • 74
    • 61649120189 scopus 로고    scopus 로고
    • Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice
    • Abraham J, Johnson RW (2009) Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav Immun 23:396-401
    • (2009) Brain Behav Immun , vol.23 , pp. 396-401
    • Abraham, J.1    Johnson, R.W.2
  • 75
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J, Buchanan JB, Sparkman NL, Godbout JP, Freund GG, Johnson RW (2008) Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 22:301-311
    • (2008) Brain Behav Immun , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 76
    • 44949225039 scopus 로고    scopus 로고
    • Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
    • Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT et al (2008) Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation 5:15
    • (2008) J Neuroinflammation , vol.5 , pp. 15
    • Henry, C.J.1    Huang, Y.2    Wynne, A.3    Hanke, M.4    Himler, J.5    Bailey, M.T.6
  • 77
    • 78650420511 scopus 로고    scopus 로고
    • The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1beta expression
    • Tarr AJ, McLinden KA, Kranjac D, Kohman RA, Amaral W, Boehm GW (2011) The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1beta expression. Behav Brain Res 217:481-485
    • (2011) Behav Brain Res , vol.217 , pp. 481-485
    • Tarr, A.J.1    McLinden, K.A.2    Kranjac, D.3    Kohman, R.A.4    Amaral, W.5    Boehm, G.W.6
  • 78
    • 51449117700 scopus 로고    scopus 로고
    • Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide
    • Huang Y, Henry CJ, Dantzer R, Johnson RW, Godbout JP (2008) Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging 29:1744-1753
    • (2008) Neurobiol Aging , vol.29 , pp. 1744-1753
    • Huang, Y.1    Henry, C.J.2    Dantzer, R.3    Johnson, R.W.4    Godbout, J.P.5
  • 79
    • 49549087762 scopus 로고    scopus 로고
    • Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system
    • Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O'Connor J et al (2008) Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 33:2341-2351
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2341-2351
    • Godbout, J.P.1    Moreau, M.2    Lestage, J.3    Chen, J.4    Sparkman, N.L.5    O'Connor, J.6
  • 80
    • 77649208936 scopus 로고    scopus 로고
    • Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice
    • Abraham J, Johnson RW (2009) Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res 12:445-453
    • (2009) Rejuvenation Res , vol.12 , pp. 445-453
    • Abraham, J.1    Johnson, R.W.2
  • 82
    • 38449087454 scopus 로고    scopus 로고
    • Age increases vulnerability to bacterial endotoxin-induced behavioral decrements
    • Kohman RA, Tarr AJ, Byler SL, Boehm GW (2007) Age increases vulnerability to bacterial endotoxin-induced behavioral decrements. Physiol Behav 91:561-565
    • (2007) Physiol Behav , vol.91 , pp. 561-565
    • Kohman, R.A.1    Tarr, A.J.2    Byler, S.L.3    Boehm, G.W.4
  • 83
    • 77951623176 scopus 로고    scopus 로고
    • Differential sensitivity to endotoxin exposure in young and middle-age mice
    • Kohman RA, Crowell B, Kusnecov AW (2010) Differential sensitivity to endotoxin exposure in young and middle-age mice. Brain Behav Immun 24:486-492
    • (2010) Brain Behav Immun , vol.24 , pp. 486-492
    • Kohman, R.A.1    Crowell, B.2    Kusnecov, A.W.3
  • 84
    • 2542637241 scopus 로고    scopus 로고
    • Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice
    • Verbitsky M, Yonan AL, Malleret G, Kandel ER, Gilliam TC, Pavlidis P (2004) Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. Learn Mem 11:253-260
    • (2004) Learn Mem , vol.11 , pp. 253-260
    • Verbitsky, M.1    Yonan, A.L.2    Malleret, G.3    Kandel, E.R.4    Gilliam, T.C.5    Pavlidis, P.6
  • 86
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging
    • Weaver, J.D., Huang, M.H., Albert, M., Harris, T., Rowe, J.W. and Seeman, T.E. (2002) Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology 59:371-8.
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 88
    • 0030446007 scopus 로고    scopus 로고
    • Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease
    • Alvarez XA, Franco A, Fernandez-Novoa L, Cacabelos R (1996) Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease. Mol Chem Neuropathol 29:237-252
    • (1996) Mol Chem Neuropathol , vol.29 , pp. 237-252
    • Alvarez, X.A.1    Franco, A.2    Fernandez-Novoa, L.3    Cacabelos, R.4
  • 89
    • 0033966340 scopus 로고    scopus 로고
    • Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: Peripheral inflammation or signals from the brain?
    • Licastro F, Pedrini S, Caputo L, Annoni G, Davis LJ, Ferri C et al (2000) Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain? J Neuroimmunol 103:97-102
    • (2000) J Neuroimmunol , vol.103 , pp. 97-102
    • Licastro, F.1    Pedrini, S.2    Caputo, L.3    Annoni, G.4    Davis, L.J.5    Ferri, C.6
  • 90
    • 0034757008 scopus 로고    scopus 로고
    • Intravenous human interleukin-1alpha impairs memory processing in mice: Dependence on blood-brain barrier transport into posterior division of the septum
    • Banks WA, Farr SA, La Scola ME, Morley JE (2001) Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J Pharmacol Exp Ther 299:536-541
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 536-541
    • Banks, W.A.1    Farr, S.A.2    La Scola, M.E.3    Morley, J.E.4
  • 91
    • 0028857633 scopus 로고
    • Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: Evidence for vagal mediation of immunebrain communication
    • Watkins LR, Goehler LE, Relton JK, Tartaglia N, Silbert L, Martin D et al (1995) Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immunebrain communication. Neurosci Lett 183: 27-31
    • (1995) Neurosci Lett , vol.183 , pp. 27-31
    • Watkins, L.R.1    Goehler, L.E.2    Relton, J.K.3    Tartaglia, N.4    Silbert, L.5    Martin, D.6
  • 92
    • 4644233272 scopus 로고    scopus 로고
    • Cytokine-induced sickness behaviour: A neuroimmune response to activation of innate immunity
    • Dantzer R (2004) Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500:399-411
    • (2004) Eur J Pharmacol , vol.500 , pp. 399-411
    • Dantzer, R.1
  • 93
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ et al (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86: 7611-7615
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7611-7615
    • Griffin, W.S.1    Stanley, L.C.2    Ling, C.3    White, L.4    MacLeod, V.5    Perrot, L.J.6
  • 94
    • 0025763298 scopus 로고
    • Interleukin-6 and alpha-2-macroglobulin indicate an acutephase state in Alzheimer's disease cortices
    • Bauer J, Strauss S, Schreiter-Gasser U, Ganter U, Schlegel P, Witt I et al (1991) Interleukin-6 and alpha-2-macroglobulin indicate an acutephase state in Alzheimer's disease cortices. FEBS Lett 285:111-114
    • (1991) FEBS Lett , vol.285 , pp. 111-114
    • Bauer, J.1    Strauss, S.2    Schreiter-Gasser, U.3    Ganter, U.4    Schlegel, P.5    Witt, I.6
  • 96
    • 63849193695 scopus 로고    scopus 로고
    • Microglial activation and amyloid deposition in mild cognitive impairment: A PET study
    • Okello A, Edison P, Archer HA, Turkheimer FE, Kennedy J, Bullock R et al (2009) Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 72:56-62
    • (2009) Neurology , vol.72 , pp. 56-62
    • Okello, A.1    Edison, P.2    Archer, H.A.3    Turkheimer, F.E.4    Kennedy, J.5    Bullock, R.6
  • 97
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan M, Gill S, Samii A (2003) Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 327:128
    • (2003) BMJ , vol.327 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 98
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function: Plasticity, network dynamics, and cognition
    • Rosenzweig ES, Barnes CA (2003) Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol 69:143-179
    • (2003) Prog Neurobiol , vol.69 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 99
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • van Praag H, Shubert T, Zhao C, Gage FH (2005) Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680-8685
    • (2005) J Neurosci , vol.25 , pp. 8680-8685
    • Van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 101
    • 59649095732 scopus 로고    scopus 로고
    • Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    • Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, Lie DC et al (2009) Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 16:147-154
    • (2009) Learn Mem , vol.16 , pp. 147-154
    • Jessberger, S.1    Clark, R.E.2    Broadbent, N.J.3    Clemenson Jr., G.D.4    Consiglio, A.5    Lie, D.C.6
  • 103
    • 50249153471 scopus 로고    scopus 로고
    • Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice
    • Clark PJ, Brzezinska WJ, Thomas MW, Ryzhenko NA, Toshkov SA, Rhodes JS (2008) Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience 155:1048-1058
    • (2008) Neuroscience , vol.155 , pp. 1048-1058
    • Clark, P.J.1    Brzezinska, W.J.2    Thomas, M.W.3    Ryzhenko, N.A.4    Toshkov, S.A.5    Rhodes, J.S.6
  • 104
    • 0036436191 scopus 로고    scopus 로고
    • Neurogenesis
    • may relate to some but not all types of hippocampal-dependent learning
    • Shors TJ, Townsend DA, Zhao M, Kozorovitskiy Y, Gould E (2002) Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 12:578-584
    • (2002) Hippocampus , vol.12 , pp. 578-584
    • Shors, T.J.1    Townsend, D.A.2    Zhao, M.3    Kozorovitskiy, Y.4    Gould, E.5
  • 105
    • 70349467897 scopus 로고    scopus 로고
    • Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain
    • Clark PJ, Brzezinska WJ, Puchalski EK, Krone DA, Rhodes JS (2009) Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain. Hippocampus 19:937-950
    • (2009) Hippocampus , vol.19 , pp. 937-950
    • Clark, P.J.1    Brzezinska, W.J.2    Puchalski, E.K.3    Krone, D.A.4    Rhodes, J.S.5
  • 107
    • 0347364630 scopus 로고    scopus 로고
    • Migration and differentiation of neural precursor cells can be directed by microglia
    • Aarum J, Sandberg K, Haeberlein SL, Persson MA (2003) Migration and differentiation of neural precursor cells can be directed by microglia. Proc Natl Acad Sci U S A 100: 15983-15988
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15983-15988
    • Aarum, J.1    Sandberg, K.2    Haeberlein, S.L.3    Persson, M.A.4
  • 109
    • 31544460682 scopus 로고    scopus 로고
    • Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    • Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N et al (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 9:268-275
    • (2006) Nat Neurosci , vol.9 , pp. 268-275
    • Ziv, Y.1    Ron, N.2    Butovsky, O.3    Landa, G.4    Sudai, E.5    Greenberg, N.6
  • 110
    • 33644960523 scopus 로고    scopus 로고
    • Neurogenic niche modulation by activated microglia: Transforming growth factor beta increases neurogenesis in the adult dentate gyrus
    • Battista D, Ferrari CC, Gage FH, Pitossi FJ (2006) Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci 23:83-93
    • (2006) Eur J Neurosci , vol.23 , pp. 83-93
    • Battista, D.1    Ferrari, C.C.2    Gage, F.H.3    Pitossi, F.J.4
  • 111
    • 76949088419 scopus 로고    scopus 로고
    • Chronic expression of transforming growth factor-beta enhances adult neurogenesis
    • Mathieu P, Piantanida AP, Pitossi F (2010) Chronic expression of transforming growth factor-beta enhances adult neurogenesis. Neuroimmunomodulation 17:200-201
    • (2010) Neuroimmunomodulation , vol.17 , pp. 200-201
    • Mathieu, P.1    Piantanida, A.P.2    Pitossi, F.3
  • 113
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje ML, Toda H, Palmer TD (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science 302:1760-1765
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 114
    • 79957800434 scopus 로고    scopus 로고
    • Age-related effects on hippocampal precursor cell subpopulations and neurogenesis
    • Walter J, Keiner S, Witte OW, Redecker C (2011) Age-related effects on hippocampal precursor cell subpopulations and neurogenesis. Neurobiol Aging 32(10):1906-1914
    • (2011) Neurobiol Aging , vol.32 , Issue.10 , pp. 1906-1914
    • Walter, J.1    Keiner, S.2    Witte, O.W.3    Redecker, C.4
  • 115
    • 77956463731 scopus 로고    scopus 로고
    • Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice
    • Kuzumaki N, Ikegami D, Imai S, Narita M, Tamura R, Yajima M et al (2010) Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse 64:721-728
    • (2010) Synapse , vol.64 , pp. 721-728
    • Kuzumaki, N.1    Ikegami, D.2    Imai, S.3    Narita, M.4    Tamura, R.5    Yajima, M.6
  • 117
    • 0015799240 scopus 로고
    • Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
    • Bliss TV, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232:331-356
    • (1973) J Physiol , vol.232 , pp. 331-356
    • Bliss, T.V.1    Lomo, T.2
  • 118
    • 0034042406 scopus 로고    scopus 로고
    • Synaptic plasticity and memory: An evaluation of the hypothesis
    • Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649-711
    • (2000) Annu Rev Neurosci , vol.23 , pp. 649-711
    • Martin, S.J.1    Grimwood, P.D.2    Morris, R.G.3
  • 119
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA (2006) The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem 99:1263-1272
    • (2006) J Neurochem , vol.99 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5    Lynch, M.A.6
  • 120
    • 15744373610 scopus 로고    scopus 로고
    • Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus
    • Nolan Y, Maher FO, Martin DS, Clarke RM, Brady MT, Bolton AE et al (2005) Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus. J Biol Chem 280:9354-9362
    • (2005) J Biol Chem , vol.280 , pp. 9354-9362
    • Nolan, Y.1    Maher, F.O.2    Martin, D.S.3    Clarke, R.M.4    Brady, M.T.5    Bolton, A.E.6
  • 121
    • 64749084436 scopus 로고    scopus 로고
    • Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area
    • Min SS, Quan HY, Ma J, Han JS, Jeon BH, Seol GH (2009) Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area. Neurosci Lett 456:20-24
    • (2009) Neurosci Lett , vol.456 , pp. 20-24
    • Min, S.S.1    Quan, H.Y.2    Ma, J.3    Han, J.S.4    Jeon, B.H.5    Seol, G.H.6
  • 122
    • 77953218064 scopus 로고    scopus 로고
    • Synaptic correlates of increased cognitive vulnerability with aging: Peripheral immune challenge and aging interact to disrupt theta-burst latephase long-term potentiation in hippocampal area CA1
    • Chapman TR, Barrientos RM, Ahrendsen JT, Maier SF, Patterson SL (2010) Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst latephase long-term potentiation in hippocampal area CA1. J Neurosci 30:7598-7603
    • (2010) J Neurosci , vol.30 , pp. 7598-7603
    • Chapman, T.R.1    Barrientos, R.M.2    Ahrendsen, J.T.3    Maier, S.F.4    Patterson, S.L.5
  • 123
    • 0029671172 scopus 로고    scopus 로고
    • Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
    • Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ (1996) Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci Lett 203:17-20
    • (1996) Neurosci Lett , vol.203 , pp. 17-20
    • Cunningham, A.J.1    Murray, C.A.2    O'Neill, L.A.3    Lynch, M.A.4    O'Connor, J.J.5
  • 124
    • 0033943842 scopus 로고    scopus 로고
    • The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogenactivated protein kinase ERK
    • Tancredi V, D'Antuono M, Cafe C, Giovedi S, Bue MC, D'Arcangelo G et al (2000) The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogenactivated protein kinase ERK. J Neurochem 75:634-643
    • (2000) J Neurochem , vol.75 , pp. 634-643
    • Tancredi, V.1    D'Antuono, M.2    Cafe, C.3    Giovedi, S.4    Bue, M.C.5    D'Arcangelo, G.6
  • 126
    • 78149245073 scopus 로고    scopus 로고
    • Role of inflammation in cognitive impairment: Results of observational epidemiological studies and clinical trials
    • Gorelick PB (2010) Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Ann N Y Acad Sci 1207:155-162
    • (2010) Ann N y Acad Sci , vol.1207 , pp. 155-162
    • Gorelick, P.B.1
  • 127
    • 33847772417 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of dietary restriction in slowing aging processes
    • Morgan TE, Wong AM, Finch CE (2007) Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdiscip Top Gerontol 35:83-97
    • (2007) Interdiscip Top Gerontol , vol.35 , pp. 83-97
    • Morgan, T.E.1    Wong, A.M.2    Finch, C.E.3
  • 128
  • 129
    • 0032910605 scopus 로고    scopus 로고
    • The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction
    • Morgan TE, Xie Z, Goldsmith S, Yoshida T, Lanzrein AS, Stone D et al (1999) The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience 89:687-699
    • (1999) Neuroscience , vol.89 , pp. 687-699
    • Morgan, T.E.1    Xie, Z.2    Goldsmith, S.3    Yoshida, T.4    Lanzrein, A.S.5    Stone, D.6
  • 130
    • 26244433532 scopus 로고    scopus 로고
    • Macrosialin increases during normal brain aging are attenuated by caloric restriction
    • Wong AM, Patel NV, Patel NK, Wei M, Morgan TE, de Beer MC et al (2005) Macrosialin increases during normal brain aging are attenuated by caloric restriction. Neurosci Lett 390:76-80
    • (2005) Neurosci Lett , vol.390 , pp. 76-80
    • Wong, A.M.1    Patel, N.V.2    Patel, N.K.3    Wei, M.4    Morgan, T.E.5    De Beer, M.C.6
  • 131
    • 45249117903 scopus 로고    scopus 로고
    • High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    • Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS et al (2008) High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem 106:475-485
    • (2008) J Neurochem , vol.106 , pp. 475-485
    • Thirumangalakudi, L.1    Prakasam, A.2    Zhang, R.3    Bimonte-Nelson, H.4    Sambamurti, K.5    Kindy, M.S.6
  • 132
    • 0035888177 scopus 로고    scopus 로고
    • Vitamin e suppression of microglial activation is neuroprotective
    • Li Y, Liu L, Barger SW, Mrak RE, Griffin WS (2001) Vitamin E suppression of microglial activation is neuroprotective. J Neurosci Res 66:163-170
    • (2001) J Neurosci Res , vol.66 , pp. 163-170
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Mrak, R.E.4    Griffin, W.S.5
  • 133
    • 0041884769 scopus 로고    scopus 로고
    • Protective effect of flavonoids against aging-and lipopolysaccharide- induced cognitive impairment in mice
    • Patil CS, Singh VP, Satyanarayan PS, Jain NK, Singh A, Kulkarni SK (2003) Protective effect of flavonoids against aging-and lipopolysaccharide-induced cognitive impairment in mice. Pharmacology 69:59-67
    • (2003) Pharmacology , vol.69 , pp. 59-67
    • Patil, C.S.1    Singh, V.P.2    Satyanarayan, P.S.3    Jain, N.K.4    Singh, A.5    Kulkarni, S.K.6
  • 134
    • 77958133125 scopus 로고    scopus 로고
    • Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice
    • Jang S, Dilger RN, Johnson RW (2010) Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 140:1892-1898
    • (2010) J Nutr , vol.140 , pp. 1892-1898
    • Jang, S.1    Dilger, R.N.2    Johnson, R.W.3
  • 136
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: Key roles of growth factor cascades and inflammation
    • Cotman CW, Berchtold NC, Christie LA (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 30:464-472
    • (2007) Trends Neurosci , vol.30 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.A.3
  • 138
    • 2642559636 scopus 로고    scopus 로고
    • Influence of physical activity on serum IL-6 and IL-10 levels in healthy older men
    • Jankord R, Jemiolo B (2004) Influence of physical activity on serum IL-6 and IL-10 levels in healthy older men. Med Sci Sports Exerc 36:960-964
    • (2004) Med Sci Sports Exerc , vol.36 , pp. 960-964
    • Jankord, R.1    Jemiolo, B.2
  • 139
    • 0033026518 scopus 로고    scopus 로고
    • Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages
    • Ferrandez MD, De la Fuente M (1999) Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages. Acta Physiol Scand 166:47-53
    • (1999) Acta Physiol Scand , vol.166 , pp. 47-53
    • Ferrandez, M.D.1    De La Fuente, M.2
  • 140
    • 55749105157 scopus 로고    scopus 로고
    • Effects of physical training on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat
    • Chennaoui M, Drogou C, Gomez-Merino D (2008) Effects of physical training on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat. Eur Cytokine Netw 19:8-14
    • (2008) Eur Cytokine Netw , vol.19 , pp. 8-14
    • Chennaoui, M.1    Drogou, C.2    Gomez-Merino, D.3
  • 141
    • 79960278270 scopus 로고    scopus 로고
    • Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity
    • Funk JA, Gohlke J, Kraft AD, McPherson CA, Collins JB, Jean Harry G (2011) Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain Behav Immun 25(6):1063-1077
    • (2011) Brain Behav Immun , vol.25 , Issue.6 , pp. 1063-1077
    • Funk, J.A.1    Gohlke, J.2    Kraft, A.D.3    McPherson, C.A.4    Collins, J.B.5    Jean Harry, G.6
  • 143
    • 0038322493 scopus 로고    scopus 로고
    • Exercise and IL-6 infusion inhibit endotoxin-induced TNFalpha production in humans
    • Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK (2003) Exercise and IL-6 infusion inhibit endotoxin-induced TNFalpha production in humans. FASEB J 17: 884-886
    • (2003) FASEB J , vol.17 , pp. 884-886
    • Starkie, R.1    Ostrowski, S.R.2    Jauffred, S.3    Febbraio, M.4    Pedersen, B.K.5
  • 144
    • 6344233647 scopus 로고    scopus 로고
    • Cytokine changes in the horizontal diagonal band of Broca in the septum after running and stroke: A correlation to glial activation
    • Ang ET, Wong PT, Moochhala S, Ng YK (2004) Cytokine changes in the horizontal diagonal band of Broca in the septum after running and stroke: a correlation to glial activation. Neuroscience 129:337-347
    • (2004) Neuroscience , vol.129 , pp. 337-347
    • Ang, E.T.1    Wong, P.T.2    Moochhala, S.3    Ng, Y.K.4
  • 145
    • 79960208166 scopus 로고    scopus 로고
    • Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice
    • Ehninger D, Wang LP, Klempin F, Romer B, Kettenmann H, Kempermann G (2011) Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice. Cell Tissue Res 345:69-86
    • (2011) Cell Tissue Res , vol.345 , pp. 69-86
    • Ehninger, D.1    Wang, L.P.2    Klempin, F.3    Romer, B.4    Kettenmann, H.5    Kempermann, G.6
  • 146
    • 0041672217 scopus 로고    scopus 로고
    • Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex
    • Ehninger D, Kempermann G (2003) Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex. Cereb Cortex 13:845-851
    • (2003) Cereb Cortex , vol.13 , pp. 845-851
    • Ehninger, D.1    Kempermann, G.2
  • 147
    • 77956924897 scopus 로고    scopus 로고
    • Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    • Stranahan AM, Lee K, Becker KG, Zhang Y, Maudsley S, Martin B et al (2010) Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging 31:1937-1949
    • (2010) Neurobiol Aging , vol.31 , pp. 1937-1949
    • Stranahan, A.M.1    Lee, K.2    Becker, K.G.3    Zhang, Y.4    Maudsley, S.5    Martin, B.6


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