Effects of doxapram, prethcamide and lobeline on spirometric, blood gas and acid-base variables in healthy new-born calves

Veterinary Journal

Volumn 194, Issue 2, 2012, Pages 240-246

  Bleul, U ^a   Bylang, T ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Blood gas; Doxapram; Lobeline; New born calves; Prethcamide; Spirometry

Indexed keywords

BICARBONATE; CARBON DIOXIDE; DOXAPRAM; LOBELINE; OXYGEN; PRETHCAMIDE;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ARTERIAL GAS; ARTERIAL PRESSURE; ARTICLE; BLOOD GAS ANALYSIS; BREATHING RATE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG MECHANISM; ECHOGRAPHY; EXPIRATORY FLOW; EXPIRATORY RESERVE VOLUME; FEMALE; LUNG MINUTE VOLUME; MALE; NEWBORN; NONHUMAN; OXYGEN TENSION; PEAK INSPIRATORY FLOW; PH; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY;

ACID-BASE EQUILIBRIUM; AMINOBUTYRATES; ANIMALS; ANIMALS, NEWBORN; ASPHYXIA; BICARBONATES; BLOOD GAS ANALYSIS; CARBON DIOXIDE; CATTLE; CATTLE DISEASES; DOXAPRAM; HYDROGEN-ION CONCENTRATION; KINETICS; LOBELINE; OXYGEN; PULMONARY GAS EXCHANGE; RESPIRATION; RESPIRATORY RATE; RESPIRATORY SYSTEM AGENTS; SPIROMETRY;

EID: 84868680692     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2012.04.007     Document Type: Article

References (47)

1. Anderton J.L., Harris E.A. Ventilatory effects of prethcamide in healthy young men. British Journal of Pharmacology 1963, 20:139-149.
2. Anonymous, 1998. Prethcamide (Crothetamide and Cropropamide) - Summary Report. Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products, EMEA, vol. EMEA/MRL/385/98-FINAL, London.
3. Bairam A., Blanchard P.W., Mullahoo K., Beharry K., Laudignon N., Aranda J.V. Pharmacodynamic effects and pharmacokinetic profiles of keto-Doxapram and Doxapram in newborn lambs. Pediatric Research 1990, 28:142-146.
4. Beretta C., Faustini R., Gallina G. Analeptic medication in domestic animals: Species differences observed with doxapram and combinations of it with other stimulants. Veterinary Record 1973, 92:217-221.
5. Berglund B., Steinbock L., Elvander M. Causes of stillbirth and time of death in Swedish Holstein calves examined post mortem. Acta Veterinaria Scandinavica 2003, 44:111-120.
6. Bleul U. Risk factors and rates of perinatal and postnatal mortality in cattle in Switzerland. Livestock Science 2011, 135:257-264.
7. Bleul U., Bachofner C., Stocker H., Hassig M., Braun U. Comparison of sodium bicarbonate and carbicarb for the treatment of metabolic acidosis in newborn calves. Veterinary Record 2005, 156:202-206.
8. Bleul U., Lejeune B., Schwantag S., Kahn W. Blood gas and acid-base analysis of arterial blood in 57 newborn calves. Veterinary Record 2007, 161:688-691.
9. Bleul U., Bircher B., Jud R.S., Kutter A.P. Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves. Theriogenology 2010, 73:612-619.
10. Buess C., Pietsch P., Guggenbuhl W., Koller E.A. A pulsed diagonal-beam ultrasonic airflow meter. Journal of Applied Physiology 1986, 61:1195-1199.
11. Bureau F., Coghe J., Uystepruyst C.H., Desmecht D., Lekeux P. Maximal ventilation assessment in healthy calves. The Veterinary Journal 1999, 157:309-314.
12. Bureau F., Uystepruyst C.H., Coghe J., Van De Weerdt M.L., Lekeux P. Spirometric variables recorded after Lobeline administration in healthy Friesian and Belgian White and Blue calves: Normal values and effects of somatic growth. The Veterinary Journal 1999, 157:302-308.
13. Daniel S.S., Dawes G.S., James L.S., Ross B.B. Analeptics and the resuscitation of asphyxiated monkeys. British Medical Journal 1966, 2:562-563.
14. Eden G.J., Hanson M.A. Maturation of the respiratory response to acute hypoxia in the newborn rat. Journal of Physiology 1987, 392:1-9.
15. Eigenmann U.J. Der Einfluss geburtshilflicher Massnahmen auf die Lebensfähigkeit neugeborener Kälber. Der praktische Tierarzt 1981, 62:933-942.
16. Funderburk W.H., Oliver K.L., Ward J.W. Modification of cerebral blood flow in dogs with Doxapram Hydrochlorid. Toxicology and Applied Pharmacology 1968, 13:67-75.
17. Giguere S., Sanchez L.C., Shih A., Szabo N.J., Womble A.Y., Robertson S.A. Comparison of the effects of caffeine and doxapram on respiratory and cardiovascular function in foals with induced respiratory acidosis. American Journal of Veterinary Research 2007, 68:1407-1416.
18. Giguere S., Slade J.K., Sanchez L.C. Retrospective comparison of caffeine and doxapram for the treatment of hypercapnia in foals with hypoxic-ischemic encephalopathy. Journal of Veterinary Internal Medicine 2008, 22:401-405.
19. Gulliksen S.M., Lie K.I., Loken T., Osteras O. Calf mortality in Norwegian dairy herds. Journal of Dairy Science 2009, 92:2782-2795.
20. Gundelach Y., Essmeyer K., Teltscher M.K., Hoedemaker M. Risk factors for perinatal mortality in dairy cattle: Cow and foetal factors, calving process. Theriogenology 2009, 71:901-909.
21. Gupta P.K., Moore J. The use of doxapram in the newborn. BJOG: An International Journal of Obstetrics and Gynaecology 1973, 80:1002-1006.
22. Herfen, K., 1997. überprüfung verschiedener Therapiemodelle bei der neonatalen Atemdepression des Kalbes unter Berücksichtigung klinischer und blutgasanalytischer Vitalitätskriterien. Thesis (Diss.), Giessen.
23. Herfen K., Bostedt H. Zum Säure-Basen-Status bei neugeborenen Kälbern in den ersten Lebenstagen unter Berücksichtigung differenter Vitalitätssituationen. Berliner und Münchner Tierärztliche Wochenschrift 1999, 112:166-171.
24. 2 in horses with chronic obstructive pulmonary disease and the effect of Lobelin hydrochloride on these indices. Veterinary Research Communications 2001, 25:401-412.
25. Kersting K. Postpartum care of cow and calf. Current Therapy in Large Animal Theriogenology 1997, 324-329. Saunders Elsevier, Missouri. R.S. Youngquist, W.R. Threlfall (Eds.).
26. Kochli O. Klinische Erfahrungen mit dem Atemstimulans Respirot besonders bei der Asphyxie neugeborener Kälber. Schweizer Archiv fur Tierheilkunde 1969, 111:28-32.
27. Li G.-c., Zhang H.-t., Jiao Y.-g., Wu Z.-h., Fang F., Cheng J. Glial cells are involved in the exciting effects of Doxapram on brainstem slices in vitro. Cellular and Molecular Neurobiology 2010, 30:667-670.
28. Lombard J.E., Garry F.B., Tomlinson S.M., Garber L.P. Impacts of dystocia on health and survival of dairy calves. Journal of Dairy Science 2007, 90:1751-1760.
29. Marlin, D., Smith, N., Hollingworth, C., Roberts, C., Schroter, R., Allen, W., Rossdale, P., Ousey, J., Lekeux, P., 1997. Preliminary investigation into the use of lobelin to assess respiratory capacity and mechanics in 10 day old foals. In: 15th Comparative Respiratory Society Meeting, Liège, Belgium, p. P/2.8.
30. Marlin D.J., Roberts C.A., Schroter R.C., Lekeux P. Respiratory responses of mature horses to intravenous lobeline bolus. Equine Veterinary Journal 2000, 32:200-207.
31. Mee J.F. Prevalence of, and risk factors associated with, perinatal calf mortality in pasture-based Holstein-Friesian cows. Animal: An International Journal of Animal Bioscience 2008, 2:613-620.
32. Meyer C.L., Berger P.J., Koehler K.J., Thompson J.R., Sattler C.G. Phenotypic trends in incidence of stillbirth for Holsteins in the United States. Journal of Dairy Science 2001, 84:515-523.
33. Meyfeldt, B.K., 2004. Die Blutgasfibel. Radiometer, Willich.
34. Nishino T., Mokashi A., Lahiri S. Stimulation of carotid chemoreceptors and ventilation by doxapram in the cat. Journal of Applied Physiology 1982, 52:1261-1265.
35. Phillips B., Zideman D., Wyllie J., Richmond S., van Reempts P. A statement from the Paediatric Life Support Working Group and approved by the Executive Committee of the European Resuscitation Council: European Resuscitation Council Guidelines 2000 for Newly Born Life Support. Resuscitation 2001, 48:235-239.
36. Plumb D.C. Plumb's Veterinary Drug Handbook 2005, Blackwell Publishing, Ames, Iowa, 2005. Fifth Ed.
37. Richter, B.R., 2005. Prognostische Aussagekraft arterieller gegenüber venöser Blutgasparameter im wiederholten Messrhythmus hinsichtlich des Schweregrades des neonatalen Atemnotsyndroms beim Kalb. Thesis (Diss.), Giessen.
38. Sams R.A., Gerken D.F., Ashcraft S.M. Pharmacokinetics of intravenous and oral prethcamide in horses. Journal of Pharmaceutical and Biomedical Analysis 1997, 15:639-651.
39. Steinbock L., Nasholm A., Berglund B., Johansson K., Philipsson J. Genetic effects on stillbirth and calving difficulty in Swedish Holsteins at first and second calving. Journal of Dairy Science 2003, 86:2228-2235.
40. Szenci, O., 1986. The use of Dopram-V, Lobelin and Respirot in newborn calves: A preliminary note. In: Proceedings of the 14th World Congress on Disease of Cattle, p. 1283.
41. Szenci O. Role of acid-base disturbances in perinatal mortality of calves: A review. Veterinary Bulletin 2003, 73:7R-14R.
42. Szenci O., Taverne M.A., Bakonyi S., Erdodi A. Comparison between pre- and postnatal acid-base status of calves and their perinatal mortality. Veterinary Quarterly 1988, 10:140-144.
43. Uystepruyst C.H., Coghe J., Dorts T.H., Harmegnies N., Delsemme M.H., Art T., Lekeux P. Effect of three resuscitation procedures on respiratory and metabolic adaptation to extra uterine life in newborn calves. The Veterinary Journal 2002, 163:30-44.
44. van Lunteren E., Haxhiu M.A., Mitra J., Cherniack N.S. Effects of dopamine, isoproterenol, and lobeline on cranial and phrenic motoneurons. Journal of Applied Physiology 1984, 56:737-745.
45. Varga J., Mester L., Borzsonyi L., Erdesz C., Vari A., Kormoczi P.S., Szenci O. Adaptation of respiration to extrauterine-life in healthy newborn calves. Reproduction in Domestic Animals 1999, 34:377-379.
46. Winnie A.P. Chemical respirogenesis: A comparative study. Acta Anaesthesiologica Scandinavica. Suppl. 1973, 51:1-32.
47. Yost C.S. A new look at the respiratory stimulant doxapram. CNS Drug Reviews 2006, 12:236-249.