Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours

Cellular Oncology

Volumn 35, Issue 4, 2012, Pages 301-308

  Cookson, Victoria J ^a   Bentley, Michael A ^b   Hogan, Brian V ^c   Horgan, Kieran ^c   Hayward, Bruce E ^a   Hazelwood, Lee D ^b   Hughes, Thomas A ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Cancer biomarkers; MicroRNAs; Normalisation; Plasma; Serum

Indexed keywords

MICRORNA; MICRORNA 16; MICRORNA 18B; UNCLASSIFIED DRUG;

ARTICLE; BREAST TUMOR; CANCER RECURRENCE; CANCER SURGERY; CLINICAL ARTICLE; GENE EXPRESSION; HUMAN; PLASMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BREAST NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MICRORNAS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84868680237     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-012-0089-1     Document Type: Article

References (32)

1. B. John, A.J. Enright, A. Aravin, T. Tuschl, C. Sander, D.S. Marks, Human MicroRNA targets. PLoS Biol 2, e363 (2004)
2. K. Breving, A. Esquela-Kerscher, The complexities of microRNA regulation: mirandering around the rules. Int. J. Biochem. Cell Biol. 42, 1316-1329 (2010)
3. E.T. Verghese, A.M. Hanby, V. Speirs, T.A. Hughes, Small is beautiful: microRNAs and breast cancer-where are we now? J. Pathol. 215, 214-221 (2008) (Pubitemid 351956702)
4. C.H. Lawrie, S. Gal, H.M. Dunlop, B. Pushkaran, A.P. Liggins, K. Pulford, Detection of elevated levels of tumour-associated micro-RNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 141, 672-675 (2008) (Pubitemid 351667616)
5. X. Chen, Y. Ba, L. Ma, X. Cai, Y. Yin, K. Wang, Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18, 997-1006 (2008)
6. P.S. Mitchell, R.K. Parkin, E.M. Kroh, B.R. Fritz, S.K. Wyman, E.L. Pogosova-Agadjanyan, Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U. S. A. 105, 10513-10518 (2008)
7. J.C. Brase, D. Wuttig, R. Kuner, H. Sultmann, Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer 9, 306 (2010)
8. K. Wang, S. Zhang, B. Marzolf, P. Troisch, A. Brightman, Z. Hu, Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl. Acad. Sci. U. S. A. 106, 4402-4407 (2009)
9. H. Schwarzenbach, D.S. Hoon, K. Pantel, Cell-free nucleic acids as biomarkers in cancer patients. Nat. Rev. Cancer 11, 426-437 (2011)
10. M.P. Hunter, N. Ismail, X. Zhang, B.D. Aguda, E.J. Lee, L. Yu, Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 3, e3694 (2008)
11. A. Turchinovich, L. Weiz, A. Langheinz, B. Burwinkel, Characterization of extracellular circulating microRNA. Nucleic Acids Res 39, 7223-7233 (2011)
12. H.M. Heneghan, N. Miller, A.J. Lowery, K.J. Sweeney, J. Newell, M.J. Kerin, Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann. Surg. 251, 499-505 (2010)
13. H. Cheng, L. Zhang, D.E. Cogdell, H. Zheng, A.J. Schetter, M. Nykter, Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One 6, e17745 (2011)
14. L. Pigati, S.C. Yaddanapudi, R. Iyengar, D.J. Kim, S.A. Hearn, D. Danforth, Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One 5, e13515 (2010)
15. F. Wang, Z. Zheng, J. Guo, X. Ding, Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor. Gynecol. Oncol. 119, 586-593 (2010)
16. C. Roth, B. Rack, V. Muller,W. Janni, K. Pantel, H. Schwarzenbach, Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res 12, R90 (2010)
17. B.V. Hogan, M.B. Peter, R. Achuthan, A.J. Beaumont, F.E. Langlands, S. Shakes, Perioperative reductions in circulating lymphocyte levels predict wound complications after excisional breast cancer surgery. Ann. Surg. 253, 360-364 (2011)
18. H.M. Heneghan, N. Miller, M.J. Kerin, Circulating microRNAs: promising breast cancer Biomarkers. Breast Cancer Res 13, 402 (2011)
19. H.M. Heneghan, N. Miller, R. Kelly, J. Newell, M.J. Kerin, Systemic miRNA-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage disease. Oncologist 15, 673-682 (2010)
20. H. Zhao, J. Shen, L. Medico, D. Wang, C.B. Ambrosone, S. Liu, A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS One 5, e13735 (2010)
21. E. van Schooneveld, M.C. Wouters, I. Van der Auwera, D.J. Peeters, H. Wildiers, P.A. Van Dam, Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers. Breast Cancer Res 14, R34 (2012)
22. P. Mestdagh, P. Van Vlierberghe, A. De Weer, D. Muth, F. Westermann, F. Speleman, A novel and universal method for micro-RNA RT-qPCR data normalization. Genome Biol. 10, R64 (2009)
23. J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, Accurate normalization of real-time quantitative RTPCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, RESEARCH0034 (2002)
24. P. Qian, Z. Zuo, Z. Wu, X. Meng, G. Li, Z. Wu, Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 71, 6463-6474 (2011)
25. Y. Zhao, C. Deng, J. Wang, J. Xiao, Z. Gatalica, R.R. Recker, Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer. Breast Cancer Res Treat 127, 69-80 (2011)
26. S.K. Leivonen, R. Makela, P. Ostling, P. Kohonen, S. Haapa-Paananen, K. Kleivi, Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene 28, 3926-3936 (2009)
27. K. Tjensvoll, K.N. Svendsen, J.M. Reuben, S. Oltedal, B. Gilje, R. Smaaland, miRNA expression profiling for identification of potential breast cancer biomarkers. Biomarkers (2012). doi:10.3109/ 1354750X.2012.686061
28. M. Nugent, N. Miller, M.J. Kerin, Circulating miR-34a levels are reduced in colorectal cancer. J. Surg. Oncol. (2012). doi:10.1002/ jso.23174
29. H. Kanemaru, S. Fukushima, J. Yamashita, N. Honda, R. Oyama, A. Kakimoto, The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker. J. Dermatol. Sci. 61, 187-193 (2011)
30. S. Komatsu, D. Ichikawa, H. Takeshita, M. Tsujiura, R. Morimura, H. Nagata, Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma. Br. J. Cancer 105, 104-111 (2011)
31. CC Pritchard, E Kroh, B Wood, JD Arroyo, KJ Dougherty, MM Miyaji, et al., Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev. Res. (Phila.) 5, 492-497 (2011)
32. R. Duttagupta, R. Jiang, J. Gollub, R.C. Getts, K.W. Jones, Impact of cellular miRNAs on circulating miRNA biomarker signatures. PLoS One 6, e20769 (2011)