Influence of conversion from cyclosporine A to tacrolimus on insulin sensitivity assessed by euglicaemic hyperinsulinemic clamp technique in patients after kidney transplantation

Annals of Transplantation

Volumn 17, Issue 3, 2012, Pages 61-68

  Bułanowski, Maciej ^a   Chudek, Jerzy ^a   Wiecek, Andrzej ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Calcineurin inhibitors; Diabetes mellitus; Insulin sensitivity; Kidney transplantation

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; GLUCOSE; INSULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ADULT; ARTICLE; BIOTRANSFORMATION; BODY MASS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; DRUG DOSE REDUCTION; FEMALE; GINGIVA HYPERPLASIA; GLOMERULUS FILTRATION RATE; GLUCOSE CLAMP TECHNIQUE; GRAFT RECIPIENT; HUMAN; HYPERINSULINEMIA; HYPERLIPIDEMIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MALE; NEPHROTOXICITY; TREATMENT DURATION;

EID: 84868675109     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: 10.12659/aot.883459     Document Type: Article

References (42)

1. Annual Report 2007; ERA-EDTA Registry June 2009 http://www.era-edta-reg.org
2. Basu A, Falcone J, Dvorchik I et al: Outcomes of renal transplantation in recipients with peak panel reactive antibody >30% under tacrolimusbased immunosuppression. Ann Transplant, 2011; 16: 5-13
3. Vincenti F, Friman S, Scheuermann E et al., DIRECT (Diabetes Incidence after Renal Transplantation: Neoral C Monitoring Versus Tacrolimus) Investigators. Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. Am J Transplant, 2007; 7: 1506-14
4. Cosio FG, Kudva Y, van der Velde M et al: New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation. Kidney Int, 2005; 67: 2415-21
5. Kasiske BL, Chakkera HA, Roel J: Explained and unexplained ischemic heart disease risk after renal transplantation. J Am Soc Nephrol, 2000; 11: 1735-43
6. Kasiske BL, Snyder JJ, Gilbertson D, Matas AJ: Diabetes mellitus after kidney transplantation in the United States. Am J Transplant, 2003; 3: 178-85
7. Brzezińska B, Junik R, Włodarczyk Z, Adamowicz A: Patogeneza, czynniki ryzyka i naste{ogonek}pstwa kliniczne cukrzycy po przeszczepieniu nerki. Diabetologia Praktyczna, 2007; 8: 64-69 [in Polish]
8. Markell M: Clinical impact of posttransplant diabetes mellitus. Transplant Proc, 2001; 33: 19S-22S
9. Einollahi B, Lessan-Pezeshki M, Aslani J et al: Two decades of experience in mucormycosis after kidney transplantation. Ann Transplant, 2011; 16: 44-48
10. Augustine JJ, Hricik DE: Steroid sparing in kidney transplantation: changing paradigms, improving outcomes, and remaining questions. Clin J Am Soc Nephrol, 2006; 1: 1080-89
11. Augustine JJ, Hricik DE: Steroid withdrawal: moving on to the next questions. Am J Transplant, 2009; 9: 3-4
12. Hirano Y, Fujihira S, Ohara K et al: Morphological and functional changes of islets of Langerhans in FK506-treated rats. Transplantation, 1992; 53: 889-94
13. Tze WJ, Tai J, Murase N, Tzakis A, Starzl TE: Effect of FK506 on glucose metabolism and insulin in normal rats. Transplant Proc, 1991; 23: 3158-60
14. Drachenberg CB, Klassen DK, Weir MR et al: Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation, 1999; 68: 396-402
15. Nijenhuis T, Hoenderop JG, Bindels RJ: Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia. J Am Soc Nephrol, 2004; 15: 549-57
16. Van Laecke S, Van Biesen W, Verbeke F et al: Posttransplantation hypomagnesemia and its relation with immunosuppression as predictors of new-onset diabetes after transplantation. J Am Soc Transplant, 2009; 9: 2140-49
17. Nadler JL, Buchanan T, Natarajan R et al: Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension, 1993; 21: 1024-29
18. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol, 1979; 237: E214-23
19. Rigalleau V, Gin H: Carbohydrate metabolism in uraemia. Curr Opin Clin Nutr Metab Care, 2005; 4: 463-69
20. Hornum M, Clausen P, Kjaergaard J et al: Pre-diabetes and arterial stiffness in uraemic patients. Nephrol Dial Transplant, 2010; 25: 1218-25
21. Kobayashi S, Maesato K, Moriya H et al: Insulin resistance in patients with chronic kidney disease. Am J Kidney Dis, 2005; 45: 275-80
22. Petchey WG, Hickman IJ, Duncan E et al: The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with chronic kidney disease: a randomised controlled trial. BMC Nephrol, 2009; 10: 10-41
23. Mak RH, Bettinelli A, Turner C et al: The influence of hyperparathyroidism on glucose metabolism in uremia. J Clin Endocrinol Metab, 1985; 60: 229-33
24. Wesołowski P, Saracyn M, Nowak Z, Wańkowicz Z: Insulin resistance as a novel therapeutic target in patients with chronic kidney disease treated with dialysis. Pol Arch Med Wewn, 2010; 120: 54-57
25. Biesenbach G, Raml A, Schmekal B, Eichbauer-Sturm G: Decreased insulin requirement in relation to GFR in nephropathic Type 1 and insulin-treated Type 2 diabetic patients. Diabet Med, 2003; 20: 642-45
26. Khedr E, El-Sharkawy M, Abdulwahab S et al: Effect of recombinant human erythropoietin on insulin resistance in hemodialysis patients. Hemodial Int, 2009; 13: 340-46
27. Shrishrimal K, Hart P, Michota F: Managing diabetes in hemodialysis patients: observations and recommendations. Cleve Clin J Med, 2009; 76: 649-55
28. Kobayashi S, Maejima S, Ikeda T, Nagase M: Impact of dialysis therapy on insulin resistance in end-stage renal disease: comparison of haemodialysis and continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant, 2000; 15: 65-70
29. Shrishrimal K, Hart P, Michota F: Managing diabetes in hemodialysis patients: observations and recommendations. Cleve Clin J Med, 2009; 76: 649-55
30. Hill CM, Douglas JF, Rajkumar KV et al: Glycosuria and hyperglycemia after kidney transplantation. Lancet, 1974; 2: 490
31. Arner P, Gunnarson R, Blomdahl S et al: Some characteristics of steroid diabetes: a study in renal transplant recipients receiving high dose corticosteroid therapy. Diabetes Care, 1983; 6: 23
32. Nam JH, Mun JI, Kim SI et al: b-Cell dysfunction rather than insulin resistance is the main contributing factor for the development of postrenal transplantation diabetes mellitus. Transplantation, 2001; 71: 1417-23
33. Woodward RS, Schnitzler MA, Baty J et al: Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients. Am J Transplant, 2003; 3: 590-98
34. Mayer AD, Dmitrewski J, Squifflet JP et al: Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group. Transplantation, 1997; 64: 436-43
35. Montori VM, Basu A, Erwin PJ et al: Posttransplantation diabetes: a systematic review of the literature. Diabetes Care, 2002; 25: 583-92
36. Uchizono Y, Iwase M, Nakamura U et al: Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling. J Clin Invest, 1996; 98: 2786-93
37. van Hooff JP, Christiaans MHL, van Duijnhoven EM: Evaluating mechanisms of post-transplant diabetes mellitus. Nephrol Dial Transplant, 2004; Suppl.6: vi8-vi12
38. Hjelmesæth J, Hagen LT, Asberg A et al: The impact of short-term ciclosporin A treatment on insulin secretion and insulin sensitivity in man. Nephrol Dial Transplant, 2007; 22: 1743-49
39. van Duijnhoven EM, Christiaans MH, Boots JM et al: Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. J Am Soc Nephrol, 2002; 13: 213-20
40. Hjelmesæth J, Midtvedt K, Jenssen T, Hartmann A: Insulin resistance after renal transplantation: impact of immunosuppressive and antihypertensive therapy. Diabetes Care, 2001; 24: 2121-26
41. Oterdoom LH, de Vries AP, van Son WJ et al: Validation of insulin resistance indexes in a stable renal transplant population. Diabetes Care, 2005; 28: 2424-29
42. Matthews DR, Hosker JP, Rudenski AS et al: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985; 28: 412-19