Can Topical Application of Tranexamic Acid Reduce Blood Loss in Thoracic Surgery? A Prospective Randomised Double Blind Investigation

Heart Lung and Circulation

Volumn 21, Issue 11, 2012, Pages 706-710

  Dell'Amore, Andrea ^a   Caroli, Guido ^a   Nizar, Asadi ^a   Cassanelli, Nicola ^a   Luciano, Giulia ^a   Greco, Domenico ^a   Dolci, Giampiero ^a   Bini, Alessandro ^a   Stella, Franco ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antifibrinolityc agents; Blood saving; Postoperative bleeding; Thoracic surgery; Tranexamic acid

Indexed keywords

FIBRINOGEN; HEMOGLOBIN; PLACEBO; TRANEXAMIC ACID;

AGED; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FIBRINOGEN BLOOD LEVEL; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTERNATIONAL NORMALIZED RATIO; LUNG SURGERY; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PILOT STUDY; PLEURA CAVITY; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; THORAX SURGERY; THROMBOCYTE COUNT; TREATMENT RESPONSE;

ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; THORACIC SURGERY; TRANEXAMIC ACID;

EID: 84868673765     PISSN: 14439506     EISSN: 14442892     Source Type: Journal    
DOI: 10.1016/j.hlc.2012.06.016     Document Type: Article

References (17)

1. Litle V.R., Swanson S.J. Postoperative bleeding: coagulopathy, bleeding, hemothorax. Thorac Surg Clin 2006, 16:203-207.
2. Pavie A., Szefner J., Leger P., Gandjbakhch L. Preventing, minimizing and managing postoperative bleeding. Ann Thorac Surg 1999, 68:705-710.
3. Tanaka K.A., Key N.S., Levy J.H. Blood coagualtion: hemastasis and thrombin regulation. Anesth Analg 2009, 108:143-1446.
4. Hardy J.F., Desroches J. Natural and synthetic antifibrinolytics in cardiac surgery. Can J Anaesth 1992, 39:353-365.
5. Fries D., Martini W.Z. Role of fibrinogen in trauma-induced coagulopathy. Br J Anaesth 2010, 105:116-121.
6. Kristensen K.L., Rauer L.J., Mortensen P.E., Kjeldsen B.J. Reoperation for bleeding in cardiac surgery. Interact Cardiovasc Surg 2012, 24:1-5.
7. Ranucci, Bozzetti G., Ditta A., Cotza M., Carboni G., Ballotta A. Surgical reexploration after cardiac operations: why a worse outcome?. Ann Thorac Surg 2008, 86:1557-1562.
8. Dunn C.J., Goa K.L. Tranexanic acid: a review of its use in surgery and other indication. Drugs 1999, 57:1005-1032.
9. Abrishami A., Chung F., Wong J. Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis. Can J Anesth 2009, 56:202-212.
10. De Bonis M., Cavaliere F., Alessandrini F., Lapenna E., Santarelli F., Moscato U., et al. Topical use of tranexamic acid in coronary artery bypass operations: a double-blind, prospective, randomized, placebeo-controlled study. J Thorac Cardiovasc Surg 2000, 119:575-580.
11. Baric D., Biocina B., Unic D., Sutlic Z., Rudez I., Vraca V.B., et al. Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. Eur J Cardiothorac Surg 2007, 31:366-371.
12. Spegar J., Vanek T., Snircova J., Fajt R., Straka Z., Pazderkova P., et al. Local and sustemic application of tranexamic acid in heart valve surgery: a prospective, randomized, double blind LOST study. J Thromb Thrombolysis 2011, 32:303-310.
13. Berdirhan M.A., Turna A., Yagan N., Tasci O. Aprotinin reduces postoperative bleeding and the need for blood products in thoracic surgery: results of a randomized double-blind study. Eur J Cardiothorac Surg 2001, 20:1122-1127.
14. Sirbu H., Bush T., Aleksic I., Lofti S., Ruschewski W., Dalichau H. Chest re-exploration for complications after lung surgery. Thorac Cardiovasc Surg 1999, 47:73-76.
15. Brown J.R., Birkmeyer N.J., O'Connor G.T. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 2007, 115:2801-2813.
16. Wang N.S. Anatomy and physiology of the pleural space. Clin Chest Med 1985, 6:3-16.
17. Khali P.N., Ismail M., Kalmar P., von Knobelsdorff G., Marx G. Activation of fibrinolysis in the pericardial cavity after cardiopulmonary bypass. Thromb Haemost 2004, 92:568-574.