Bias in comparative effectiveness studies due to regional variation in medical practice intensity: A legitimate concern, or much ado about nothing?

Circulation: Cardiovascular Quality and Outcomes

Volumn 5, Issue 5, 2012, Pages

  Huybrechts, Krista F ^a   Seeger, John D ^a   Rothman, Kenneth J ^a,b   Glynn, Robert J ^a   Avorn, Jerry ^a   Schneeweiss, Sebastian ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RTI HEALTH SOLUTIONS   (United States)

Author keywords

Bias; Pharmacoepidemiology; Regional variation; Research methodology; Statins

Indexed keywords

COMPARATIVE EFFECTIVENESS; GEOGRAPHY; HEALTH CARE UTILIZATION; HUMAN; MEDICAL PRACTICE; MEDICAL RESEARCH; MEDICARE; PRIORITY JOURNAL; REVIEW; SENSITIVITY ANALYSIS; SYSTEMATIC ERROR; UNITED STATES;

BIAS (EPIDEMIOLOGY); COMPARATIVE EFFECTIVENESS RESEARCH; GUIDELINE ADHERENCE; HEALTHCARE DISPARITIES; HUMANS; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES AS TOPIC; QUALITY INDICATORS, HEALTH CARE; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; RESIDENCE CHARACTERISTICS; UNITED STATES;

EID: 84868671536     PISSN: 19417713     EISSN: 19417705     Source Type: Journal    
DOI: 10.1161/CIRCOUTCOMES.112.966093     Document Type: Review

References (20)

1. Song Y, Skinner J, Bynum J, Sutherland J, Wennberg JE, Fisher ES. Regional variations in diagnostic practices. N Engl J Med. 2010;363:45-53.
2. Skinner J, Fisher E. Reflections on Geographic Variation in U. S. Health Care. 2010. Available at: http://www.dartmouthatlas.org/downloads/press/Skinner- Fisher-DA-05-10.pdf. Accessed January 2, 2012.
3. Fisher ES, Wennberg DE, Stukel T, Gottlieb DJ. Variations in the longitudinal efficiency of academic medical centers. Health Aff (Millwood). 2004; Suppl Variation: VAR19-VAR32.
4. Gottlieb DJ, Zhou W, Song Y, Andrews KG, Skinner JS, Sutherland JM. Prices don't drive regional Medicare spending variations. Health Aff (Millwood). 2010;29:537-543.
5. McClellan M, Skinner J. The incidence of Medicare. J Public Econ. 2006;90:257-276. (Pubitemid 43079208)
6. Sutherland JM, Fisher ES, Skinner JS. Getting past denial-The high cost of health care in the United States. N Engl J Med. 2009;361:1227-1230.
7. Zuckerman S, Waidmann T, Berenson R, Hadley J. Clarifying sources of geographic differences in Medicare spending. N Engl J Med. 2010;363:54-62.
8. Baker LC, Fisher ES, Wennberg JE. Variations in hospital resource use for Medicare and privately insured populations in California. Health Aff (Millwood). 2008;27:w123-w134. (Pubitemid 351490373)
9. Chernew ME, Sabik LM, Chandra A, Gibson TB, Newhouse JP. Geographic correlation between large-frm commercial spending and Medicare spending. Am J Manag Care. 2010;16:131-138.
10. Rothman K, Greenland S, Lash T. Validity in epidemiologic studies. In: Rothman KJ, Greenland S, Lash T, eds. Modern Epidemiology. 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2008:128-147.
11. Glymour MM, Greenland S. Causal diagrams. In: Rothman KJ, Greenland S, Lash T, eds. Modern Epidemiology. 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2008:183-209.
12. Schneeweiss S, Rassen JA, Glynn RJ, Avorn J, Mogun H, Brookhart MA. High-dimensional propensity score adjustment in studies of treatment effects using health care claims data. Epidemiology. 2009;20:512-522.
13. Rassen JA, Glynn RJ, Brookhart MA, Schneeweiss S. Covariate selection in high-dimensional propensity score analyses of treatment effects in small samples. Am J Epidemiol. 2011;173:1404-1413.
14. Bross ID. Spurious effects from an extraneous variable. J Chronic Dis. 1966;19:637-647.
15. Schneeweiss S. Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics. Pharmacoepidemiol Drug Saf. 2006;15:291-303. (Pubitemid 43797117)
16. Spiegelman D, Schneeweiss S, McDermott A. Measurement error correction for logistic regression models with an "alloyed gold standard". Am J Epidemiol. 1997;145:184-196. (Pubitemid 27045324)
17. Rassen JA, Choudhry NK, Avorn J, Schneeweiss S. Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Circulation. 2009;120:2322-2329.
18. Neuberg GW. The cost of end-of-life care: A new efficiency measure falls short of AHA/ACC standards. Circ Cardiovasc Qual Outcomes. 2009;2:127-133.
19. Lash TL, Fox MP, Fink AK. Applying Quantitative Bias Analysis to Epidemiologic Data. 1st ed. Springer; New York, NY: 2009.
20. Carroll R, Ruppert D, Stefanski L, Crainiceanu C. Measurement Error in Nonlinear Models: A Modern Perspective. 2nd ed. Boca Raton, Fl: Chapman & Hall/CRC; 2006.