Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform

Journal of Biomedical Optics

Volumn 17, Issue 6, 2012, Pages

  Song, Wei ^a,d   Wei, Qing ^a   Liu, Tan ^a   Kuai, David ^a   Burke, Janice M ^b   Jiao, Shuliang ^c   Zhanga, Hao F ^a  

^a Northwestern University   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d HARBIN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Fluorescein angiography; Optical coherence tomography; Photoacoustic ophthalmoscopy; Retinal imaging; Scanning laser ophthalmoscopy

Indexed keywords

CONTRAST MEDIUM; MELANIN;

ACOUSTIC MICROSCOPY; ACOUSTICS; ANIMAL; ARTICLE; DIAGNOSTIC IMAGING; FLUORESCENCE ANGIOGRAPHY; LASER; METABOLISM; METHODOLOGY; OPHTHALMOSCOPY; OPTICAL COHERENCE TOMOGRAPHY; OPTICS; PATHOLOGY; PHOTOACOUSTICS; PHOTON; PHYSIOLOGY; PIGMENTATION; RADIATION SCATTERING; RAT; RETINA; RETINA BLOOD VESSEL;

ACOUSTICS; ANIMALS; CONTRAST MEDIA; DIAGNOSTIC IMAGING; FLUORESCEIN ANGIOGRAPHY; LASERS; MELANINS; MICROSCOPY, ACOUSTIC; OPHTHALMOSCOPY; OPTICS AND PHOTONICS; PHOTOACOUSTIC TECHNIQUES; PHOTONS; PIGMENTATION; RATS; RETINA; RETINAL VESSELS; SCATTERING, RADIATION; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84868665152     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.6.061206     Document Type: Article

References (26)

1. M. Mujat et al., "High-resolution multimodal clinical ophthalmic imaging system," Opt. Express 18(11), 11607-11621 (2010).
2. R. Spaide and C. Curcio, "Drusen characterization with multimodal imaging," Retina 30(9), 1441-1454 (2010).
3. P. Issa et al., "Multimodal imaging including spectral domain OCT and confocal near infrared reflectance for characterization of outer retinal pathology in pseudoxanthoma elasticum," Investig. Ophthalmol. Vis. Sci. 50(12), 5913-5918 (2009).
4. S. Jiao et al., "Photoacoustic ophthalmoscopy for in vivo retinal imaging," Opt. Express. 18(4), 3967-3972 (2010).
5. H. F. Zhang et al., "Collecting back-reflected photons in photoacoustic microscopy," Opt. Express. 18(2), 1278-1282 (2010).
6. F. Holz and R. Spaide, "Medical retina: Focus on retinal imaging," Chapter 3, in Fluorescein Angiography, H. F. Fine, J. L. Prenner, and D. Roth, Eds., pp. 19-25, Springer, Berlin (2010).
7. W. R. Freeman et al., "Simultaneous indocyanine green and fluorescein angiography using a confocal scanning laser ophthalmoscope," Arch. Ophthalmol. 116(4), 455-463 (1998). (Pubitemid 28169745)
8. S. M. Shah et al., "Dynamic and quantitative analysis of choroidal neovascularization by fluorescein angiography," Investig. Ophthalmol. Vis. Sci. 47(12), 5460-5468 (2006). (Pubitemid 46723798)
9. D. Pauleikhoff et al., "A fluorescein and indocyanine green angiographic study of choriocapillaris in age-related macular disease," Arch. Ophthalmol. 117(10), 1353-1358 (1999). (Pubitemid 30029345)
10. G. J. Jaffe and J. Caprioli, "Optical coherence tomography to detect and manage retinal disease and glaucoma," Am. J. Ophthalmol. 137(1), 156-169 (2004). (Pubitemid 38045202)
11. H. Wehbe et al., "Automatic retinal blood flow calculation using spectral domain optical coherence tomography," Opt. Express. 15(23), 15193-15206 (2007). (Pubitemid 350127653)
12. Q. Wei et al., "Image chorioretinal vasculature in albino rats using photoacoustic ophthalmoscopy," J. Mod. Optic. 58(21), 1997-2001 (2011).
13. X. Zhang et al., "Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging," J. Biomed. Opt. 16(8), 080504 (2011).
14. S. Hu and L. V. Wang, "Photoacoustic imaging and characterization of the microvasculature," J. Biomed. Opt. 15(1), 011101 (2010).
15. J. Yao et al., "Label-free oxygen-metabolic photoacoustic microscopy in vivo," J. Biomed. Opt. 16(7), 076002 (2011).
16. T. Liu et al., "Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen," Biomed. Opt. Express 2(5), 1359-1365 (2011).
17. S. Hu et al., "Label-free photoacoustic ophthalmic angiography," Opt. Lett. 35(1), 1-3 (2010).
18. S. Jiao et al., "Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography," Opt. Lett. 34(19), 2961-2963 (2009).
19. M. Paques et al., "High-resolution fundus imaging by confocal scanning laser ophthalmoscopy in the mouse," Vis. Res. 46(8-9), 1336-1345 (2006). (Pubitemid 43075309)
20. M. Paques et al., "Structural and hemodynamic analysis of the mouse retinal microcirculation," Investig. Ophthalmol. Vis. Sci. 44(11), 4960-4967 (2003). (Pubitemid 37315315)
21. J. M. Burke and L. M. Hjelmeland, "Mosaicism of the retinal pigment epithelium: seeing the small picture," Mol. Interv. 5(4), 241-249 (2005). (Pubitemid 41242130)
22. I. A. Bhutto and T. Amemiya, "Microvascular architecture of the rat choroid: corrosion cast study," Anat. Rec. 264(1), 63-71 (2001). (Pubitemid 32800522)
23. A. I. Srienc, Z. L. Kurth-Nelson, and E. A. Newman, "Imaging retinal blood flow with laser speckle flowmetry," Front. Neuroenergetics. 2, 128 (2010
24. M. Hammer et al., "Optical properties of ocular fundus tissues-an in-vitro study using the double-integrating-sphere technique and inverse Monte-Carlo simulation," Phys. Med. Biol. 40(6), 963-978 (1995).
25. Z. Xie et al., "Laser-scanning optical-resolution photoacoustic microscopy," Opt. Lett. 34(12), 1771-1773 (2009).
26. T. Ling, S. L. Chen, and L. J. Guo, "High-sensitivity and widedirectivity ultrasound detection using high Q polymer microring resonators," Appl. Phys. Lett. 98(20), 204103 (2011).