A generalisation of T-optimality for discriminating between competing models with an application to pharmacokinetic studies

Pharmaceutical Statistics

Volumn 11, Issue 6, 2012, Pages 503-510

  Vajjah, Pavan ^a,b   Duffull, Stephen B ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b CERTARA UK LIMITED   (United Kingdom)

Author keywords

robust T optimal design; T | D optimality; T optimality

Indexed keywords

ACETYLCYSTEINE; ANTIDOTE; PARACETAMOL;

ANALYTIC METHOD; ARTICLE; COMPARTMENT MODEL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG OVERDOSE; HUMAN; MODEL; ROBUST D OPTIMALITY METHOD; SIMULATION; STATISTICAL MODEL; T OPTIMALITY METHOD; TOXIC HEPATITIS; UNCERTAINTY;

CLINICAL TRIALS AS TOPIC; DRUG DESIGN; HUMANS; MODELS, STATISTICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS; RESEARCH DESIGN;

EID: 84868664163     PISSN: 15391604     EISSN: 15391612     Source Type: Journal    
DOI: 10.1002/pst.1542     Document Type: Article

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