Association study of CRP gene polymorphism and hypertension in Han Chinese population

Gene

Volumn 512, Issue 1, 2013, Pages 41-46

  Zhao, Yanping ^a   Wang, Hairu ^b,e   Liu, Sijun ^b   Zhao, Xianghai ^a   Chen, Yanchun ^a   Yang, Yichun ^a   Wang, Wen ^a   Wu, Yiming ^a   Chen, Aiqin ^a   Tang, Junming ^a   Yao, Yingshui ^c   Li, Yun ^d   Chen, Jinfeng ^b   Shen, Chong ^b   Yang, Song ^a  

^a YIXING PEOPLE S HOSPITAL   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c WANNAN MEDICAL COLLEGE   (China)

^d HEBEI UNITED UNIVERSITY   (China)

^e NANJING INSTITUTE OF INDUSTRY TECHNOLOGY   (China)

Author keywords

Association study; CRP gene; CRPP1 gene; Hypertension

Indexed keywords

C REACTIVE PROTEIN;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; C-REACTIVE PROTEIN; CHINA; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; YOUNG ADULT;

EID: 84868624184     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.09.107     Document Type: Article

References (34)

1. Bao X., Mills P.J., Rana B.K., Dimsdale J.E., Schork N.J., Smith D.W., et al. Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function. Hypertension 2005, 46:301-307.
2. Chamarthi B., Williams G.H., Ricchiuti V., Srikumar N., Hopkins P.N., Luther J.M., et al. Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans. Am. J. Hypertens. 2011, 24:1143-1148.
3. Danesh J., Wheeler J.G., Hirschfield G.M., Eda S., Eiriksdottir G., Rumley A., et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. 2004, 350:1387-1397.
4. Dao H.H., Essalihi R., Bouvet C., Moreau P. Evolution and modulation of age-related medial elastocalcinosis: impact on large artery stiffness and isolated systolic hypertension. Cardiovasc. Res. 2005, 66:307-317.
5. den Hertog H.M., van Rossum J.A., van der Worp H.B., van Gemert H.M., de Jonge R., Koudstaal P.J., et al. C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death. J. Neurol. 2009, 256:2003-2008.
6. den Hertog H.M., van den Herik E.G., Dippel D.W., Koudstaal P.J., de Maat M.P. Variation in the C-reactive protein gene is associated with serum levels of CRP in patients with acute ischemic stroke. Cerebrovasc. Dis. 2010, 29:372-375.
7. Elkind M.S., Luna J.M., Coffey C.S., McClure L.A., Liu K.M., Spitalnik S., et al. The Levels of Inflammatory Markers in the Treatment of Stroke study (LIMITS): inflammatory biomarkers as risk predictors after lacunar stroke. Int. J. Stroke 2010, 5:117-125.
8. Genest J. C-reactive protein: risk factor, biomarker and/or therapeutic target?. Can. J. Cardiol. 2010, 26(Suppl. A):41A-44A.
9. Guan H., Wang P., Hui R., Edin M.L., Zeldin D.C., Wang D.W. Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Clin. Chem. 2009, 55:274-284.
10. Komurcu-Bayrak E., Erginel-Unaltuna N., Onat A., Ozsait B., Eklund C., Hurme M., et al. Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. Atherosclerosis 2009, 206:474-479.
11. Lake S.L., Lyon H., Tantisira K., Silverman E.K., Weiss S.T., Laird N.M., et al. Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum. Hered. 2003, 55:56-65.
12. Lasky-Su J., Lyon H.N., Emilsson V., Heid I.M., Molony C., Raby B.A., et al. On the replication of genetic associations: timing can be everything!. Am. J. Hum. Genet. 2008, 82:849-858.
13. Levy B.I., Ambrosio G., Pries A.R., Struijker-Boudier H.A. Microcirculation in hypertension: a new target for treatment?. Circulation 2001, 104:735-740.
14. Lunetta K.L., D'Agostino R.B., Karasik D., Benjamin E.J., Guo C.Y., Govindaraju R., et al. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med. Genet. 2007, 8(Suppl. 1):S13.
15. Masia M., Bernal E., Padilla S., Graells M.L., Jarrin I., Almenar M.V., et al. The role of C-reactive protein as a marker for cardiovascular risk associated with antiretroviral therapy in HIV-infected patients. Atherosclerosis 2007, 195:167-171.
16. Melzer D., Perry J.R., Hernandez D., Corsi A.M., Stevens K., Rafferty I., et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008, 4:e1000072.
17. Morita H., Nagai R. Genetically elevated C-reactive protein and vascular disease. N. Engl. J. Med. 2009, 360:934-935. (author reply).
18. Paffen E., DeMaat M.P. C-reactive protein in atherosclerosis: a causal factor?. Cardiovasc. Res. 2006, 71:30-39.
19. Percy C.J., Brown L., Power D.A., Johnson D.W., Gobe G.C. Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mech. Ageing Dev. 2009, 130:129-138.
20. Ridker P.M. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus. J. Am. Coll. Cardiol. 2007, 49:2129-2138.
21. Sabatti C., Service S.K., Hartikainen A.L., Pouta A., Ripatti S., Brodsky J., et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat. Genet. 2009, 41:35-46.
22. Safar M.E., Lajemi M., Rudnichi A., Asmar R., Benetos A. Angiotensin-converting enzyme D/I gene polymorphism and age-related changes in pulse pressure in subjects with hypertension. Arterioscler. Thromb. Vasc. Biol. 2004, 24:782-786.
23. Shen C., Lu X., Li Y., Zhao Q., Liu X., Hou L., et al. Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population. BMC Med. Genet. 2009, 10:118.
24. Skol A.D., Scott L.J., Abecasis G.R., Boehnke M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 2006, 38:209-213.
25. Song I.U., Kim J.S., Kim Y.I., Lee K.S., Jeong D.S., Chung S.W. Relationship between high-sensitivity C-reactive protein and clinical functional outcome after acute ischemic stroke in a Korean population. Cerebrovasc. Dis. 2009, 28:545-550.
26. Staessen J.A., Wang J., Bianchi G., Birkenhager W.H. Essential hypertension. Lancet 2003, 361:1629-1641.
27. Wang L., Lu X., Li Y., Li H., Chen S., Gu D. Functional analysis of the C-reactive protein (CRP) gene -717A>G polymorphism associated with coronary heart disease. BMC Med. Genet. 2009, 10:73.
28. Welsh P., Barber M., Langhorne P., Rumley A., Lowe G.D., Stott D.J. Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke. Cerebrovasc. Dis. 2009, 27:247-253.
29. Woollard K.J., Geissmann F. Monocytes in atherosclerosis: subsets and functions. Nat. Rev. Cardiol. 2010, 7:77-86.
30. Wu S., Li Y., Jin C., Yang P., Li D., Li H., et al. Intra-individual variability of high-sensitivity C-reactive protein in Chinese general population. Int. J. Cardiol. 2012, 157:75-79.
31. Yang S., Wang H., Yang Y., Wang W., Jiang J., Zhao X., et al. Association study of AGER gene polymorphism and hypertension in Han Chinese population. Gene 2012, 498:311-316.
32. Z., Z., W., Z., L. Optimal two-stage design for case-control association analysis incorporating genotyping errors. Ann. Hum. Genet. 2008, 72:375-387.
33. Zacchigna L., Vecchione C., Notte A., Cordenonsi M., Dupont S., Maretto S., et al. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell 2006, 124:929-942.
34. Zacho J., Tybjaerg-Hansen A., Jensen J.S., Grande P., Sillesen H., Nordestgaard B.G. Genetically elevated C-reactive protein and ischemic vascular disease. N. Engl. J. Med. 2008, 359:1897-1908.