Growing new kidneys from embryonic cell suspensions: Fantasy or reality?

Journal of the American Society of Nephrology

Volumn 23, Issue 11, 2012, Pages 1763-1766

  D'Agati, Vivette D ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VASCULOTROPIN;

ANTIGEN PRESENTING CELL; APOPTOSIS; BIOENGINEERING; CADAVER KIDNEY; CELL DIFFERENTIATION; CELL SUSPENSION; EDITORIAL; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; FETAL TISSUE TRANSPLANTATION; GLOMERULUS FILTRATION; GRAFT FAILURE; GRAFT RECIPIENT; HUMAN; IMMUNOGENICITY; KIDNEY DEVELOPMENT; KIDNEY DISTAL TUBULE; KIDNEY GRAFT REJECTION; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; LIVING DONOR; MESENCHYMAL STEM CELL; NEPHRON; NONHUMAN; PLURIPOTENT STEM CELL; PRIMORDIUM; PRIORITY JOURNAL; TISSUE GROWTH; URETER; XENOTRANSPLANTATION;

EID: 84868613747     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012090888     Document Type: Editorial

References (24)

1. Hammerman MR: Growing new kidneys in situ. Clin Exp Nephrol 8: 169-177, 2004
2. Hammerman MR: Xenotransplantation of pancreatic and kidney primordia-where do we stand? Transpl Immunol 21: 93-100, 2009
3. Kao RM, Vasilyev A, Miyawaki A, Drummond IA, McMahon AP: Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis [published online ahead of print August 16, 2012]. J Am Soc Nephrol doi:10.1681/ASN.2012030283
4. Kopan R, Cheng HT, Surendran K: Molecular insights into segmentation along the proximal-distal axis of the nephron. J Am Soc Nephrol 18: 2014-2020, 2007 (Pubitemid 47041065)
5. Hammerman MR: Renal organogenesis from transplanted metanephric primordia. J Am Soc Nephrol 15: 1126-1132, 2004
6. Rogers SA, Lowell JA, Hammerman NA, Hammerman MR: Transplantation of developingmetanephroi into adult rats. Kidney Int 54: 27-37, 1998
7. Yokote S, Yokoo T, Matsumoto K, Utsunomiya Y, Kawamura T, Hosoya T: The effect of metanephros transplantation on blood pressure in anephric rats with induced acute hypotension. Nephrol Dial Transplant 27: 3449-3455, 2012
8. Matsumoto K, Yokoo T, Yokote S, Utsunomiya Y, Ohashi T, Hosoya T: Functional development of a transplanted embryonic kidney: Effect of transplantation site. J Nephrol 25: 50-55, 2012
9. Dilworth MR, Clancy MJ, Marshall D, Bravery CA, Brenchley PE, Ashton N: Development and functional capacity of transplanted rat metanephroi. Nephrol Dial Transplant 23: 871-879, 2008 (Pubitemid 351767552)
10. Woolf AS, Palmer SJ, Snow ML, Fine LG: Creation of a functioning chimeric mammalian kidney. Kidney Int 38: 991-997, 1990 (Pubitemid 20362875)
11. Dekel B, Burakova T, Arditti FD, Reich-Zeliger S, Milstein O, Aviel-Ronen S, Rechavi G, Friedman N, Kaminski N, Passwell JH, Reisner Y: Human and porcine early kidney precursors as a new source for transplantation. Nat Med 9: 53- 60, 2003
12. Loughna S, Hardman P, Landels E, Jussila L, Alitalo K, Woolf AS: A molecular and genetic analysis of renalglomerular capillary development. Angiogenesis 1: 84-101, 1997 (Pubitemid 127505704)
13. Robert B, St John PL, Hyink DP, Abrahamson DR: Evidence that embryonic kidney cells expressing flk-1 are intrinsic, vasculogenic angioblasts. Am J Physiol 271: F744-F753, 1996
14. Rosines E, Sampogna RV, Johkura K, Vaughn DA, Choi Y, Sakurai H, Shah MM, Nigam SK: Staged in vitro reconstitution and implantation of engineered rat kidney tissue. Proc Natl Acad Sci U S A 104: 20938-20943, 2007
15. Steer DL, Bush KT, Meyer TN, Schwesinger C, Nigam SK: A strategy for in vitro propagation of rat nephrons. Kidney Int 62: 1958-1965, 2002 (Pubitemid 35366151)
16. Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R: Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development 133: 151-161, 2006 (Pubitemid 43169329)
17. Unbekandt M, Davies JA: Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues. Kidney Int 77: 407-416, 2010
18. Ganeva V, Unbekandt M, Davies JA: An improved kidney dissociation and reaggregation culture system results in nephrons arranged organotypically around a single collecting duct system. Organogenesis 7: 83-87, 2011
19. Schmidt-Ott KM: ROCK inhibition facilitates tissue reconstitution from embryonic kidney cell suspensions. Kidney Int 77: 387-389, 2010
20. Xinaris C, Benedetti V, Rizzo P, Abbate M, Corna D, Azzollini N, Conti S, Unbekandt M, Davies JA, Morigi M, Benigni A, Remuzzi G: In vivo maturation of functional renal organoids formed from embryonic cell suspensions. J Am Soc Nephrol 23: 1857-1868, 2012
21. Siegel N, Rosner M, Unbekandt M, Fuchs C, Slabina N, Dolznig H, Davies JA, Lubec G, Hengstschläger M: Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet 19: 3320-3331, 2010
22. Kim K, Schuetz C, Elias N, Veillette GR, Wamala I, Varma M, Smith RN, Robson SC, Cosimi AB, Sachs DH, Hertl M: Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons. Xenotransplantation 19: 256-264, 2012
23. Yokoo T, Fukui A, Ohashi T, Miyazaki Y, Utsunomiya Y, Kawamura T, Hosoya T, Okabe M, Kobayashi E: Xenobiotic kidney organogenesis fromhumanmesenchymal stem cells using a growing rodent embryo. J Am Soc Nephrol 17: 1026-1034, 2006
24. Yokoo T, Ohashi T, Shen JS, Sakurai K, Miyazaki Y, Utsunomiya Y, Takahashi M, Terada Y, Eto Y, Kawamura T, Osumi N, Hosoya T: Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues. Proc Natl Acad Sci U S A 102: 3296-3300, 2005 (Pubitemid 40328039)