Heat resistance and salt hypersensitivity in Lactococcus lactis due to spontaneous mutation of llmg_1816 (gdpP) induced by high-temperature growth

Applied and Environmental Microbiology

Volumn 78, Issue 21, 2012, Pages 7753-7759

  Smith, William M ^a   Pham, Thi Huong ^a   Lei, Lin ^a   Dou, Junchao ^a   Soomro, Aijaz H ^b   Beatson, Scott A ^a   Dykes, Gary A ^c   Turner, Mark S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b SINDH AGRICULTURE UNIVERSITY   (Pakistan)

^c MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; DURING CONSTRUCTION; GENE DELETION MUTANTS; GENE ENCODES; HEAT RESISTANT; HIGH TEMPERATURE; HIGH-TEMPERATURE GROWTH; LACTIS STRAIN; LACTOCOCCUS LACTIS; MEMBRANE-BOUND; PARENT STRAIN; PHOSPHODIESTERASE ACTIVITY; SALT CONCENTRATION; SIGNALING PROTEINS; SUICIDE VECTORS; TEMPERATURE RESISTANCES; WILD TYPES; WILD-TYPE LEVELS;

AMINO ACIDS; DNA; GENES; PROTEINS; SPECIFIC HEAT;

HEAT RESISTANCE;

CYCLIC DIADENOSINE PHOSPHATE; DINUCLEOSIDE PHOSPHATE; PHOSPHODIESTERASE; SODIUM CHLORIDE;

ACIDIFICATION; AMINO ACID; ANTIBIOTICS; BACTERIOLOGY; BACTERIUM; GENE EXPRESSION; GENOME; GROWTH; HEATING; HIGH TEMPERATURE; MILK; MUTATION; PLASMID; PROTEIN; SALT;

ARTICLE; BACTERIAL GENOME; DNA SEQUENCE; GENE DELETION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEAT; LACTOCOCCUS LACTIS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SALINITY; SIGNAL TRANSDUCTION;

BASE SEQUENCE; DINUCLEOSIDE PHOSPHATES; GENE DELETION; GENOME, BACTERIAL; HOT TEMPERATURE; LACTOCOCCUS LACTIS; MUTATION; PHOSPHORIC DIESTER HYDROLASES; SALINITY; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SODIUM CHLORIDE; STRESS, PHYSIOLOGICAL;

LACTOCOCCUS LACTIS;

EID: 84868611616     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02316-12     Document Type: Article

References (29)

1. Biswas I, Gruss A, Ehrlich SD, Maguin E. 1993. High-efficiency gene inactivation and replacement system for Gram-positive bacteria. J. Bacteriol. 175:3628-3635.
2. Corrigan RM, Abbott JC, Burhenne H, Kaever V, Grundling A. 2011. c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress. PLoS Pathog. 7:e1002217. doi:
3. Drummond AJ, et al. 2011. Geneious, version 5.4. Biomatters, Auckland, New Zealand.
4. Duwat P, Cochu A, Ehrlich SD, Gruss A. 1997. Characterization of Lactococcus lactis UV-sensitive mutants obtained by ISS1 transposition. J. Bacteriol. 179:4473-4479.
5. Duwat P, Ehrlich SD, Gruss A. 1999. Effects of metabolic flux on stress response pathways in Lactococcus lactis. Mol. Microbiol. 31:845-858.
6. Griffiths JM, O'Neill AJ. 2012. Loss of function of the GdpP protein leads to joint-lactam/glycopeptide tolerance in Staphylococcus aureus. Antimicrob. Agents Chemother. 56:579-581.
7. Harwood CR, Cutting SM (ed). 1990. Molecular biological methods for Bacillus. John Wiley and Sons, Ltd., Chichester, England.
8. Leloup L, Ehrlich SD, Zagorec M, Morel-Deville F. 1997. Singlecrossover integration in the Lactobacillus sake chromosome and insertional inactivation of the ptsI and lacL genes. Appl. Environ. Microbiol.63:2117-2123.
9. Linares DM, Kok J, Poolman B. 2010. Genome sequences of Lactococcus lactis MG1363 (revised) and NZ9000 and comparative physiological studies. J. Bacteriol. 192:5806-5812.
10. Lo R, et al. 2009. Cystathionine {gamma}-lyase is a component of cystinemediated oxidative defense in Lactobacillus reuteri BR11. J. Bacteriol. 191: 1827-1837.
11. M inβ-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis. Mol. Microbiol. 83:623-639.
12. Maguin E, Duwat P, Hege T, Ehrlich D, Gruss A. 1992. New thermosensitive plasmid for Gram-positive bacteria. J. Bacteriol. 174:5633-5638.
13. Maguin E, Prevost H, Ehrlich SD, Gruss A. 1996. Efficient insertional mutagenesis in lactococci and other Gram-positive bacteria. J. Bacteriol. 178:931-935.
14. Obis D, Guillot A, Mistou MY. 2001. Tolerance to high osmolality of Lactococcus lactis subsp. lactis and cremoris is related to the activity of a betaine transport system. FEMS Microbiol. Lett. 202:39-44.
15. Oppenheimer-Shaanan Y, Wexselblatt E, Katzhendler J, Yavin E, Ben-Yehuda S. 2011. c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis. EMBO Rep. 12:594-601.
16. Pfaffl MW, Horgan GW, Dempfle L. 2002. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30:10.
17. Rallu F, Gruss A, Ehrlich SD, Maguin E. 2000. Acid-and multistressresistant mutants of Lactococcus lactis: identification of intracellular stress signals. Mol. Microbiol. 35:517-528.
18. Rao F, Ji QA, Soehano I, Liang ZX. 2011. Unusual heme-binding PAS domain from YybT family proteins. J. Bacteriol. 193:1543-1551.
19. Rao F, et al. 2010. YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and aGGDEFdomain with ATPase activity. J. Biol. Chem. 285:473-482.
20. Rochat T, et al. 2005. Lactococcus lactis SpOx spontaneous mutants: a family of oxidative-stress-resistant dairy strains. Appl. Environ. Microbiol. 71:2782-2788.
21. Romeo Y, Bouvier J, Gutierrez C. 2007. Osmotic regulation of transcription in Lactococcus lactis: ionic strength-dependent binding of the BusR repressor to the busA promoter. FEBS Lett. 581:3387-3390.
22. Romeo Y, et al. 2003. Osmoregulation in Lactococcus lactis: BusR, a transcriptional repressor of the glycine betaine uptake system BusA. Mol. Microbiol. 47:1135-1147.
23. Romling U. 2008. Great times for small molecules: c-di-AMP, a second messenger candidate in bacteria and archaea. Sci. Signal. 1:pt4.
24. Sanders JW, Venema G, Kok J. 1999. Environmental stress responses in Lactococcus lactis. FEMS Microbiol. Rev. 23:483-501.
25. Smith WM, Dykes GA, Soomro AH, Turner MS. 2010. Molecular mechanisms of stress resistance in Lactococcus lactis, p 1106-1118. In Mendez-Vilas A (ed), Current research, technology and education topics in applied microbiology and microbial biotechnology, vol 2. FORMATEX, Badajoz, Spain.
26. Turner MS, Tan YP, Giffard PM. 2007. Inactivation of an iron transporter in Lactococcus lactis results in resistance to tellurite and oxidative stress. Appl. Environ. Microbiol. 73:6144-6149.
27. Wegmann U, et al. 2007. Complete genome sequence of the prototype lactic acid bacterium Lactococcus lactis subsp. cremoris MG1363. J. Bacteriol. 189:3256-3270.
28. Wells JM, Wilson PW, Lepage RWF. 1993. Improved cloning vectors and transformation procedure for Lactococcus lactis. J. Appl. Bacteriol. 74:629-636.
29. Witte G, Hartung S, Buttner K, Hopfner KP. 2008. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol. Cell 30:167-178.