Incidence and clinical significance of cardiac biomarker elevation during stem cell mobilization, apheresis, and intramyocardial delivery

American Heart Journal

Volumn 164, Issue 5, 2012, Pages

  Povsic, Thomas J ^a   Losordo, Douglas W ^b   Story, Kenneth ^b   Junge, Candice E ^b   Schatz, Richard A ^c   Harrington, Robert A ^a   Henry, Timothy D ^d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b BAXTER HEALTHCARE CORPORATION   (United States)

^c SCRIPPS CLINIC   (United States)

^d MINNEAPOLIS HEART INSTITUTE FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CREATINE KINASE MB; PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TROPONIN;

ADULT; AGE; AGED; ANGINA PECTORIS; APHERESIS; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART DEATH; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEM CELL MOBILIZATION;

EID: 84868608289     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2012.06.022     Document Type: Article

References (32)

1. P.H. Michael, M.O.C. Christopher, and A.G. Wendy Implications of elevated cardiac troponin t in ambulatory patients with heart failure: a prospective analysis Am Heart J 147 3 2004 546 552
2. E.M. Ohman, P.W. Armstrong, and R.H. Christenson Cardiac troponin T levels for risk stratification in acute myocardial ischemia N Engl J Med 335 18 1996 1333 1342
3. C.C.S. Lim, W.J. van Gaal, and L. Testa With the universal definition, measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after coronary intervention J Am Coll Cardiol 57 6 2011 653 661
4. W.L. Miller, K.N. Garratt, and M.F. Burritt Baseline troponin level: key to understanding the importance of post-PCI troponin elevations Eur Heart J 27 9 2006 1061 1069
5. A. Prasad, and J. Herrmann Myocardial infarction due to percutaneous coronary intervention N Eng J Med 364 5 2011 453 464
6. F. Baldazzi, E. Jorgensen, and R.S. Ripa Release of biomarkers of myocardial damage after direct intramyocardial injection of genes and stem cells via the percutaneous transluminal route Eur Heart J 29 15 2008 1819 1826
7. S. Fuchs, N. Dib, and B.M. Cohen A randomized, double-blind, placebo-controlled, multicenter, pilot study of the safety and feasibility of catheter-based intramyocardial injection of AdVEGF121 in patients with refractory advanced coronary artery disease Catheter Cardiovasc Interv 68 3 2006 372 378
8. S. Fuchs, L.F. Satler, and R. Kornowski Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease J Am Coll Card 41 2003 1721 1724
9. E.C. Perin, H.F.R. Dohmann, and R. Borojevic Transendocardial, autologous bone marrow cell transplantation for severe chronic ischemic heart failure Circulation 107 2003 2294 2302
10. D.J. Stewart, M.J. Kutryk, and D. Fitchett VEGF Gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN Trial Mol Ther 17 6 2009 1109 1115
11. H.-F. Tse, S. Thambar, and Y.-L. Kwong Safety of catheter-based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis Am J Cardiol 98 1 2006 60 62
12. D.W. Losordo, T.D. Henry, and C.J. Davidson CD34+ Cell therapy for refractory angina Circ Res 109 2011 428 436
13. Y. Kawachi, A. Watanabe, and T. Uchida Acute arterial thrombosis due to platelet aggregation in a patient receiving granulocyte colony-stimulating factor Br J Haematol 94 2 1996 413 416
14. Y. Fukumoto, T. Miyamoto, and T. Okamura Angina pectoris occurring during granulocyte colony-stimulating factor-combined preparatory regimen for autologous peripheral blood stem cell transplantation in a patient with acute myelogenous leukaemia Br J Haematol 97 3 1997 666 668
15. R. Vij, D.R. Adkins, and R.A. Brown Unstable angina in a peripheral blood stem and progenitor cell donor given granulocyte-colony stimulating factor Transfusion 39 1999 542 543
16. D. Zohlnhöfer, A. Dibra, and T. Koppara Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a meta-analysis J Am Coll Cardiol 51 15 2008 1429 1437
17. A. Abdel-Latif, R. Bolli, and E.K. Zuba-Surma Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials Am Heart J 156 2 2008 216 226.e9
18. R.F. Wilson, and T.D. Henry Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: double-edged swords J Am Coll Cardiol 46 9 2005 1649 1650
19. S. Zbinden, R. Zbinden, and P. Meier Safety and efficacy of subcutaneous-only granulocyte-macrophage colony-stimulating factor for collateral growth promotion in patients with coronary artery disease J Am Coll Cardiol 46 9 2005 1636 1642
20. J.M. Hill, M.A. Syed, and A.E. Arai Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease J Am Coll Cardiol 46 9 2005 1643 1648
21. + cell infusion in patients with chronic refractory ischemic heart disease: The G-CSF in Angina patients with IHD to stimulate Neovascularization (GAIN I) trial Am Heart J 156 5 2008 954 963
22. Y. Wang, K. Tagil, and R.S. Ripa Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease Int J Cardiol 100 3 2005 477 483
23. P. Meier, S. Gloekler, and S.F. de Marchi Myocardial salvage through coronary collateral growth by granulocyte colony-stimulating factor in chronic coronary artery disease: a controlled randomized trial Circulation 120 14 2009 1355 1363
24. D.W. Losordo, R.A. Schatz, and C.J. White Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial Circulation 115 25 2007 3165 3172
25. J. Honold, R. Lehmann, and C. Heeschen Effects of granulocyte colony stimulating factor on functional activities of endothelial progenitor cells in patients with chronic ischemic heart disease Arterioscler Thromb Vasc Biol 26 10 2006 2238 2243
26. S.-A. Chang, H.-J. Kang, and H.-Y. Lee Peripheral blood stem cell mobilisation by granulocyte-colony stimulating factor in patients with acute and old myocardial infarction for intracoronary cell infusion Heart 95 16 2009 1326 1330
27. + stem cells in patients with chronic ischemic heart disease: a 12-month follow-up Int J Cardiol 109 1 2006 21 27
28. A.M. Cavallaro, K. Lilleby, and I. Majolino Three to six year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor Bone Marrow Transplant 25 1 2000 85
29. S. Sinha, K.K. Poh, and D. Sodano Safety and efficacy of peripheral blood progenitor cell mobilization and collection in patients with advanced coronary heart disease J Clin Apher 21 2 2006 116 120
30. A.T. Turer, T.A. Addo, and J.L. Martin Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study J Am Coll Cardiol 57 24 2011 2398 2405
31. A.S. Kini, P. Lee, and J.D. Marmur Correlation of postpercutaneous coronary intervention creatine kinase-MB and troponin I elevation in predicting mid-term mortality Am J Cardiol 93 1 2004 18 23
32. G.A. Lurati Buse, M.T. Koller, and M. Grapow The prognostic value of troponin release after adult cardiac surgery - a meta-analysis Eur J Cardiothorac Surg 37 2 2010 399 406