Similarities and differences between electrocardiogram signs of left bundle-branch block and left-ventricular uncoupling

Europace

Volumn 14, Issue SUPPL. 5, 2012, Pages

  Potse, Mark ^a,b   Krause, Dorian ^a   Bacharova, Ljuba ^c,d   Krause, Rolf ^a   Prinzen, Frits W ^b   Auricchio, Angelo ^e  

^a UNIVERSITY OF LUGANO   (Switzerland)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c INTERNATIONAL LASER CENTER   (Slovakia)

^d Physics and Informatics   (Slovakia)

^e DIVISION OF CARDIOLOGY   (Switzerland)

Author keywords

Cardiac resynchronization therapy; Computer models; Conduction disease; Left bundle branch block

Indexed keywords

ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; ELECTROCARDIOGRAM; HEART ELECTROPHYSIOLOGY; HEART LEFT BUNDLE BRANCH BLOCK; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART MUSCLE POTENTIAL; HEART VENTRICLE CONDUCTION; HEART VENTRICLE PACING; PRIORITY JOURNAL; QRS COMPLEX; T WAVE;

ACTION POTENTIALS; ANIMALS; BUNDLE-BRANCH BLOCK; COMPUTER SIMULATION; DIAGNOSIS, COMPUTER-ASSISTED; DIAGNOSIS, DIFFERENTIAL; ELECTROCARDIOGRAPHY; HEART CONDUCTION SYSTEM; HUMANS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84868600281     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eus272     Document Type: Article

References (32)

1. Strauss DG, Selvester RH, Wagner GS. Defining left bundle branch block in the era of cardiac resynchronization therapy. Am J Cardiol 2011;107:927-34.
2. Auricchio A, Fantoni C, Regoli F, Carbucicchio C, Goette A, Geller C et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 2004;109:1133-9.
3. Bacharova L, Mateasik A, Krause R, Prinzen FW, Auricchio A, Potse M. The effect of reduced intercellular coupling on electrocardiographic signs of left ventricular hypertrophy. J Electrocardiol 2011;44:571-6.
4. Potse M. Mathematical modeling and simulation of ventricular activation sequences: implications for cardiac resynchronization therapy. J Cardiovasc Transl Res 2012;5:146-58.
5. Zareba W, Klein H, Cygankiewicz I, Hall WJ, McNitt S, Brown M et al. Effectiveness of cardiac resynchronization therapy by QRS morphology in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT). Circulation 2011;123:1061-72.
6. Hoogendijk MG, Potse M, Linnenbank AC, Verkerk AO, den Ruijter HM, van Amersfoorth SCM et al. Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. Heart Rhythm 2010;7:238-48.
7. Potse M, Dubé B, Vinet A. Cardiac anisotropy in boundary-element models for the electrocardiogram. Med Biol Eng Comput 2009;47:719-29.
8. Potse M, Dubé B, Richer J, Vinet A, Gulrajani RM. A comparison of monodomain and bidomain reaction-diffusion models for action potential propagation in the human heart. IEEE Trans Biomed Eng 2006;53:2425-35.
9. ten Tusscher KHWJ, Noble D, Noble PJ, Panfilov AV. A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 2004;286:H1573-89.
10. Potse M, Vinet A, Opthof T, Coronel R. Validation of a simple model for the morphology of the T wave in unipolar electrograms. Am J Physiol Heart Circ Physiol 2009;297:H792-801.
11. Krause D, Potse M, Dickopf T, Krause R, Auricchio A, Prinzen FW. Poster: hybrid parallelization of a realistic heart model. In SC11; The International Conference for High Performance Computing, Networking, Storage, and Analysis. Seattle, WA, USA, Nov. 2011.
12. Krause D, Potse M, Dickopf T, Krause R, Auricchio A, Prinzen FW. Hybrid parallelization of a large-scale heart model. In Facing the Multicore-Challenge II, volume 7174 of Lecture Notes in Computer Science., Berlin, 2012.
13. Lorange M, Gulrajani RM. A computer heart model incorporating anisotropic propagation: I. Model construction and simulation of normal activation. J Electrocardiol 1993;26:245-261.
14. Durrer D, van Dam RT, Freud GE, Janse MJ, Meijler FL, Arzbaecher RC. Total excitation of the isolated human heart. Circulation 1970;41:899-912.
15. Henriquez CS. Simulating the electrical behavior of cardiac tissue using the bidomain model. CRC Crit Rev Biomed Eng 1993;21:1-77.
16. Jongsma HJ, Wilders R. Gap junctions in cardiovascular disease. Circ Res 2000;86: 1193-1197.
17. Zimmerman HA, Hellerstein HK. Cavity potentials of the human ventricles. Circulation 1951;3:95-104.
18. Durrer D, van der Tweel LH, Blickman Jr. Spread of activation in the left ventricular wall of the dog. III. Transmural and intramural analysis. Am Heart J 1954;48: 13-35.
19. Strik M, Rademakers LM, van Deursen CJM, van Hunnik A, Kuiper M, Klersy C et al. Endocardial left ventricular pacing improves cardiac resynchronization therapy in chronic asynchronous infarction and heart failure models. Circ Arrhythmia and Electrophysiol 2012;5:191-200.
20. Surawicz B, Childers R, Deal BJ, Gettes LS. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram Part III: intraventricular conduction disturbances; a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Circulation 2009;119:e235-40.
21. van Dijk J, Dijkmans PA, Götte MJW, Spreeuwenberg MD, Visser CA, Kamp O. Evaluation of global left ventricular function and mechanical dyssynchrony in patients with an asymptomatic left bundle branch block: a real-time 3D echocardiography study. Eur J Echocardiography 2008;9:40-6.
22. Lorange M, Gulrajani RM, Nadeau RA, Préda I. A computer heart model incorporating anisotropic propagation: II. Simulations of conduction block. J Electrocardiol 1993;26:263-77.
23. Bacharova L, Szathmary V, Mateasik A. Electrocardiographic patterns of left bundle-branch block caused by intraventricular conduction impairment in working myocardium: a model study. J Electrocardiol 2011;44:568-70.
24. Kléber A, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 2004;84:431-88.
25. Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res 2008;80:9-19.
26. Bacharova L, Plandorova J, Klimas J, Krenek P, Kyselovic J. Discrepancy between increased left ventricular mass and 'normal' QRS voltage is associated with decreased connexin 43 expression in early stage of left ventricular hypertrophy in spontaneously hypertensive rats. J Electrocardiol 2008;41:730-4.
27. Stein M, Boulaksil M, Jansen JA, Herold E, Noorman M, Joles JA et al. Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin- aldosterone system inhibitors in an aged mouse model. Am J Physiol Heart Circ Physiol 2010;299: H310-21.
28. Danik SB, Liu F, Zhang J, Suk HJ, Morley GE, Fishman GI et al. Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res 2004;95: 1035-41.
29. Conrath CE, Opthof T. Ventricular repolarization: an overview of (patho)physiology, sympathetic effects and genetic aspects. Prog Biophys Mol Biol 2006;92: 269-307.
30. Keller DUJ, Weiss DL, Dössel O, Seemann G. Influence of IKs heterogeneities on the genesis of the T-wave: a computational evaluation. IEEE Trans Biomed Eng 2012;59:311-22.
31. Myerburg RJ, Gelband H, Nilsson K, Castellanos A, Morales AR, Bassett AL. The role of canine superficial ventricular muscle fibers in endocardial impulse distribution. Circ Res 1978;42:27-35.
32. Priebe L, Beuckelmann DJ. Simulation study of cellular electric properties in heart failure. Circ Res 1998;82:1206-23.