Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity

Plant Biotechnology Journal

Volumn 10, Issue 9, 2012, Pages 1026-1034

  Arjó, Gemma ^a   Capell, Teresa ^a   Matias Guiu, Xavier ^a   Zhu, Changfu ^a   Christou, Paul ^a,b   Piñol, Carme ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Genetically engineered corn; Safety assessment; Sub chronic toxicity

Indexed keywords

VITAMIN;

ANIMAL; ARTICLE; FEMALE; MAIZE; MALE; MOUSE; TOXICITY TESTING; TRANSGENIC PLANT;

ANIMALS; FEMALE; MALE; MICE; PLANTS, GENETICALLY MODIFIED; TOXICITY TESTS, SUBACUTE; TOXICITY TESTS, SUBCHRONIC; VITAMINS; ZEA MAYS;

ANIMALIA; MUS; ZEA MAYS;

EID: 84868569042     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/j.1467-7652.2012.00730.x     Document Type: Article

References (28)

1. AOAC International (2000) Official Methods of Analysis of AOAC International, 17th edn. Gaithersburg, MD: Association of Official Analytical Chemists.
2. Appenzeller, L.M., Munley, S.M., Hoban, D., Sykes, G.P., Malley, L.A. and Delaney, B. (2009) Subchronic feeding study of grain from herbicide-tolerant maize DP-Ø9814Ø-6 in Sprague-Dawley rats. Food Chem. Toxicol. 47, 2269-2280.
3. Bai, C., Twyman, R.M., Farre, G., Sanahuja, G., Christou, P., Capell, T. and Zhu, C.F. (2011) A golden era pro-vitamin A enhancement in diverse crops. In Vitro Cell. Dev. Biol. Plant 47, 205-221.
4. DEEM™, 2002 Acute Version 7.77. Washington DC, USA: Exponent, Inc.
5. European Food Safety Authority (2006) Guidance document of the Scientific Panel on Genetically Modified Organisms for the risk assessment of genetically modified plants and derived food and feed. EFSA J. 99, 1-100.
6. European Food Safety Authority (2011a) Guidance for risk assessment of food and feed from genetically modified plants. EFSA J. 9, 2150-2187.
7. European Food Safety Authority (2011b) Guidance on conducting repeated-dose 90-day oral toxicity study in rodents on whole food/feed. EFSA J. 9, 2438-2459.
8. Farre, G., Ramessar, K., Twyman, R.M., Capell, T. and Christou, P. (2010a) The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption. Curr. Opin. Plant Biol. 13, 219-225.
9. Farre, G., Sanahuja, G., Naqvi, S., Bai, C., Capell, T., Zhu, C.F. and Christou, P. (2010b) Travel advice on the road to carotenoids in plants. Plant Sci. 179, 28-48.
10. Farre, G., Twyman, R.M., Zhu, C., Capell, T. and Christou, P. (2011a) Nutritionally enhanced crops and food security: scientific achievements versus political expediency. Curr. Opin. Biotechnol. 22, 245-251.
11. Farre, G., Bai, C., Twyman, R.M., Capell, T., Christou, P. and Zhu, C. (2011b) Nutritious crops producing multiple carotenoids - a metabolic balancing act. Trends Plant Sci. 16, 532-540.
12. Food and Agriculture Organization (2009) The State of Food and Agriculture. Rome: Food and Agriculture Organization.
13. Gomez-Galera, S., Rojas, E., Sudhakar, D., Zhu, C., Pelacho, A.M., Capell, T. and Christou, P. (2010) Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Res. 19, 165-180.
14. Hammond, B., Dudek, R., Lemen, J. and Nemeth, M. (2004) Results of a 13week safety assurance study with rats fed grain from glyphosate tolerant corn. Food Chem. Toxicol. 42, 1003-1014.
15. Hammond, B.G., Dudek, R., Lemen, J.K. and Nemeth, M.A. (2006) Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn. Food Chem. Toxicol. 44, 1092-1099.
16. van Haver, E., Alink, G., Barlow, S., Cockburn, A., Flachowsky, G., Knudsen, I., Kuiper, H., Massin, D.P., Pascal, G., Peijnenburg, A., Phipps, R., Poting, A., Poulsen, M., Seinen, W., Spielmann, H., van Loveren, H., Wal, J.M. and Williams, A. (2008) Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials. Food Chem. Toxicol. 46, S2-S70.
17. Healy, C., Hammond, B. and Kirkpatrick, J. (2008) Results of a 13-week safety assurance study with rats fed grain from corn rootworm-protected, glyphosate-tolerant MON 88017 corn. Food Chem. Toxicol. 46, 2517-2524.
18. Konig, A., Cockburn, A., Crevel, R.W.R., Debruyne, E., Grafstroem, R., Hammerling, U., Kimber, I., Knudsen, I., Kuiper, H.A., Peijnenburg, A.A.C.M., Penninks, A.H., Poulsen, M., Schauzu, M. and Wal, J.M. (2004) Assessment of the safety of foods derived from genetically modified (GM) crops. Food Chem. Toxicol. 42, 1047-1088.
19. Kuiper, H.A., Kleter, G.A., Noteborn, H.P. and Kok, E.J. (2001) Assessment of the food safety issues related to genetically modified foods. Plant J. 27, 503-528.
20. Naqvi, S., Zhu, C.F., Farre, G., Ramessar, K., Bassie, L., Breitenbach, J., Conesa, D.P., Ros, G., Sandmann, G., Capell, T. and Christou, P. (2009) Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proc. Natl Acad. Sci. USA 106, 7762-7767.
21. Naqvi, S., Farre, G., Sanahuja, G., Capell, T., Zhu, C.F. and Christou, P. (2010) When more is better: multigene engineering in plants. Trends Plant Sci. 15, 48-56.
22. Paine, J.A., Shipton, C.A., Chaggar, S., Howells, R.M., Kennedy, M.J., Vernon, G., Wright, S.Y., Hinchliffe, E., Adams, J.L., Silverstone, A.L. and Drake, R. (2005) Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat. Biotechnol. 23, 482-487.
23. Potrykus, I. (2010) Lessons from the 'Humanitarian Golden Rice' project: regulation prevents development of public good genetically engineered crop products. N. Biotechnol. 27, 466-472.
24. Ramessar, K., Capell, T., Twyman, R.M. and Christou, P. (2010) Going to ridiculous lengths-European coexistence regulations for GM crops. Nat. Biotechnol. 28, 133-136.
25. Sabalza, M., Miralpeix, B., Twyman, R.M., Capell, T. and Christou, P. (2011) EU legitimizes GM crop exclusion zones. Nat. Biotechnol. 29, 315-317.
26. Ye, X.D., Al-Babili, S., Kloti, A., Zhang, J., Lucca, P., Beyer, P. and Potrykus, I. (2000) Engineering the provitamin a (β-Carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science, 287, 303-305.
27. Zhu, C., Naqvi, S., Gomez-Galera, S., Pelacho, A.M., Capell, T. and Christou, P. (2007) Transgenic strategies for the nutritional enhancement of plants. Trends Plant Sci. 12, 548-555.
28. Zhu, C.F., Naqvi, S., Breitenbach, J., Sandmann, G., Christou, P. and Capell, T. (2008) Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize. Proc. Natl Acad. Sci. USA, 105, 18232-18237.