Generation of a novel, cyclooxygenase-2-targeted, interferon-expressing, conditionally replicative adenovirus for pancreatic cancer therapy

American Journal of Surgery

Volumn 204, Issue 5, 2012, Pages 741-750

  Armstrong, Leonard ^a   Arrington, Amanda ^a   Han, Joohee ^a   Gavrikova, Tatyana ^b   Brown, Eric ^a   Yamamoto, Masato ^a   Vickers, Selwyn M ^a   Davydova, Julia ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Adenoviral death protein (ADP); Adenovirus; Conditionally replicative adenovirus (CRAd); Cox2; Gene therapy; Interferon alfa; Krumdiek tissue slicer; Oncolytic virus; Pancreatic cancer

Indexed keywords

ALPHA INTERFERON; CONDITIONALLY REPLICATING ADENOVIRUS; CYCLOOXYGENASE 2;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; VIRUS INFECTIVITY; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRUS E3 PROTEINS; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CYCLOOXYGENASE 2; FEMALE; GENE TRANSFER TECHNIQUES; HUMANS; INTERFERON-ALPHA; MICE; MICE, NUDE; ONCOLYTIC VIROTHERAPY; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VIRUS REPLICATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84868547011     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2012.02.016     Document Type: Article

References (38)

1. Cancer Facts & Figures 2010 2010 American Cancer Society Atlanta http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/ cancer-facts-figures-2010-rev Available from: Accessed: September 2011.
2. N.B. Merchant, A.A. Parikh, E.H. Liu Adjuvant chemoradiation therapy for pancreas cancer: who really benefits? Adv Surg 44 2010 149 164
3. M.H. Katz, H. Wang, J.B. Fleming Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma Ann Surg Oncol 16 2009 836 847
4. J. Gómez-Navarro, D.T. Curiel Conditionally replicative adenoviral vectors for cancer gene therapy Lancet Oncol 1 2000 148 158
5. J.R. Hecht, R. Bedford, J.L. Abbruzzese A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma Clin Cancer Res 9 2003 555 561
6. E. Schenk, M. Essand, C.H. Bangma Clinical adenoviral gene therapy for prostate cancer Hum Gene Ther 21 2010 807 813
7. A. Young, I.A. McNeish Oncolytic adenoviral gene therapy in ovarian cancer: why we are not wasting our time Future Oncol 5 2009 339 357
8. T.R. Reid, S. Freeman, L. Post Effects of onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin Cancer Gene Ther 12 2005 673 681
9. M. Yamamoto, D.T. Curiel Current issues and future directions of oncolytic adenoviruses Mol Ther 18 2010 243 250
10. R. Alemany, M. Cascallo Oncolytic viruses from the perspective of the immune system Future Microbiol 4 2009 527 536
11. J. Davydova, T. Gavrikova, E.J. Brown In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacy Cancer Sci 101 2010 474 481
12. P.J. Ramírez, S.M. Vickers, H.A. Ono Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model Am J Surg 195 2008 481 490
13. M. Yamamoto, J. Davydova, M. Wang Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer Gastroenterology 125 2003 1203 1218
14. K. Doronin, K. Toth, M. Kuppuswamy Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus Virology 305 2003 378 387
15. Y. Nukui, V.J. Picozzi, L.W. Traverso Interferon-based adjuvant chemoradiation therapy improves survival after pancreaticoduodenectomy for pancreatic adenocarcinoma Am J Surg 179 2000 367 371
16. D.C. Linehan, M.C. Tan, S.M. Strasberg Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study Ann Surg 248 2008 145 151
17. V.J. Picozzi, R.A. Abrams, P.A. Decker Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b-based chemoradiation: ACOSOG trial Z05031 Ann Oncol 22 2011 348 354
18. V.J. Picozzi, R.A. Kozarek, L.W. Traverso Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma Am J Surg 185 2003 476 480
19. H. Hara, A. Kobayashi, K. Yoshida Local interferon-alpha gene therapy elicits systemic immunity in a syngeneic pancreatic cancer model in hamster Cancer Sci 98 2007 455 463
20. F.J. Fallaux, O. Kranenburg, S.J. Cramer Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors Hum Gene Ther 7 1996 215 222
21. J. Davydova, L.P. Le, T. Gavrikova Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment Cancer Res 64 2004 4319 4327
22. M. Yamamoto, R. Alemany, Y. Adachi Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers Mol Ther 3 2001 385 394
23. H.A. Ono, L.P. Le, J.G. Davydova Noninvasive visualization of adenovirus replication with a fluorescent reporter in the E3 region Cancer Res 65 2005 10154 10158
24. M. Sunamura, H. Hamada, F. Motoi Oncolytic virotherapy as a novel strategy for pancreatic cancer Pancreas 28 2004 326 329
25. R. Alemany Cancer selective adenoviruses Mol Aspects Med 28 2007 42 58
26. K. Garber China approves world's first oncolytic virus therapy for cancer treatment J Natl Cancer Inst 98 2006 298 300
27. B.M. Yan, J. Van Dam Endoscopic ultrasound-guided intratumoural therapy for pancreatic cancer Can J Gastroenterol 22 2008 405 410
28. A. Cascante, D. Abate-Daga, L. Garcia-Rodríguez GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the tat8-TK as a late gene in a pancreatic tumour model Gene Ther 14 2007 1471 1480
29. M.A. Trujillo, M.J. Oneal, S. McDonough A probasin promoter, conditionally replicating adenovirus that expresses the sodium iodide symporter (NIS) for radiovirotherapy of prostate cancer Gene Ther 17 2010 1325 1332
30. S. Bortolanza, M. Bunuales, I. Otano Treatment of pancreatic cancer with an oncolytic adenovirus expressing interleukin-12 in Syrian hamsters Mol Ther 17 2009 614 622
31. K. Furukawa, T. Ohashi, K. Haruki Combination treatment using adenovirus vector-mediated tumor necrosis factor-alpha gene transfer and a NF-kappaB inhibitor for pancreatic cancer in mice Cancer Lett 306 2011 92 98
32. F. Motoi, M. Sunamura, L. Ding Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus Hum Gene Ther 11 2000 223 235
33. P. Sova, X.W. Ren, S. Ni A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases Mol Ther 9 2004 496 509
34. V.N. Krasnykh, G.V. Mikheeva, J.T. Douglas Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism J Virol 70 1996 6839 6846
35. J.G. Wesseling, M. Yamamoto, Y. Adachi Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma Cancer Gene Ther 8 2001 990 996
36. R.N. Dubois, S.B. Abramson, L. Crofford Cyclooxygenase in biology and disease FASEB J 12 1998 1063 1073
37. M. Ohashi, K. Yoshida, M. Kushida Adenovirus-mediated interferon alpha gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer Br J Cancer 93 2005 441 449
38. E.V. Shashkova, M.N. Kuppuswamy, W.S. Wold Anticancer activity of oncolytic adenovirus vector armed with IFN-alpha and ADP is enhanced by pharmacologically controlled expression of TRAIL Cancer Gene Ther 15 2008 61 72